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Article: Label-free electrical detection of DNA hybridization on graphene using Hall effect measurements: Revisiting the sensing mechanism

TitleLabel-free electrical detection of DNA hybridization on graphene using Hall effect measurements: Revisiting the sensing mechanism
Authors
Keywordsliquid-gated transistors
label-free detection
Hall effect measurements
DNA sensors
graphene
Issue Date2013
Citation
Advanced Functional Materials, 2013, v. 23, n. 18, p. 2301-2307 How to Cite?
AbstractThere is broad interest in using graphene or graphene oxide sheets as a transducer for label-free and selective electrical detection of biomolecules such as DNA. However, it is still not well explored how the DNA molecules interact with and influence the properties of graphene during the detection. Here, Hall effect measurements based on the Van der Pauw method are used to perform single-base sequence selective detection of DNA on graphene sheets, which are prepared by chemical vapor deposition. The sheet resistance increases and the mobility decreases with the addition of either complementary or one-base mismatched DNA to the graphene device. The hole carrier concentration of the graphene devices increases significantly with the addition of complementary DNA but it is less affected by the one-base mismatched DNA. It is concluded that the increase in hole carrier density, indicating p-doping to graphene, is better correlated with the DNA hybridization compared to the commonly used parameters such as conductivity change. The different electrical observations of p-doping from Hall effect measurements and n-doping from electrolyte-gated transistors can be explained by the characteristic morphology of partially hybridized DNA on graphene and the mismatch between DNA chain length and Debye length in electrolytes. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Persistent Identifierhttp://hdl.handle.net/10722/298031
ISSN
2020 Impact Factor: 18.808
2015 SCImago Journal Rankings: 5.210

 

DC FieldValueLanguage
dc.contributor.authorLin, Cheng Te-
dc.contributor.authorLoan, Phan Thi Kim-
dc.contributor.authorChen, Tzu Yin-
dc.contributor.authorLiu, Keng Ku-
dc.contributor.authorChen, Chang Hsiao-
dc.contributor.authorWei, Kung Hwa-
dc.contributor.authorLi, Lain Jong-
dc.date.accessioned2021-04-08T03:07:30Z-
dc.date.available2021-04-08T03:07:30Z-
dc.date.issued2013-
dc.identifier.citationAdvanced Functional Materials, 2013, v. 23, n. 18, p. 2301-2307-
dc.identifier.issn1616-301X-
dc.identifier.urihttp://hdl.handle.net/10722/298031-
dc.description.abstractThere is broad interest in using graphene or graphene oxide sheets as a transducer for label-free and selective electrical detection of biomolecules such as DNA. However, it is still not well explored how the DNA molecules interact with and influence the properties of graphene during the detection. Here, Hall effect measurements based on the Van der Pauw method are used to perform single-base sequence selective detection of DNA on graphene sheets, which are prepared by chemical vapor deposition. The sheet resistance increases and the mobility decreases with the addition of either complementary or one-base mismatched DNA to the graphene device. The hole carrier concentration of the graphene devices increases significantly with the addition of complementary DNA but it is less affected by the one-base mismatched DNA. It is concluded that the increase in hole carrier density, indicating p-doping to graphene, is better correlated with the DNA hybridization compared to the commonly used parameters such as conductivity change. The different electrical observations of p-doping from Hall effect measurements and n-doping from electrolyte-gated transistors can be explained by the characteristic morphology of partially hybridized DNA on graphene and the mismatch between DNA chain length and Debye length in electrolytes. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.-
dc.languageeng-
dc.relation.ispartofAdvanced Functional Materials-
dc.subjectliquid-gated transistors-
dc.subjectlabel-free detection-
dc.subjectHall effect measurements-
dc.subjectDNA sensors-
dc.subjectgraphene-
dc.titleLabel-free electrical detection of DNA hybridization on graphene using Hall effect measurements: Revisiting the sensing mechanism-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/adfm.201202672-
dc.identifier.scopuseid_2-s2.0-84877310902-
dc.identifier.volume23-
dc.identifier.issue18-
dc.identifier.spage2301-
dc.identifier.epage2307-
dc.identifier.eissn1616-3028-
dc.identifier.issnl1616-301X-

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