File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1016/S0014-2999(98)00194-0
- Scopus: eid_2-s2.0-0032557469
- PMID: 9671097
- WOS: WOS:000074286800008
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Differential expression of pre- and postsynaptic GABA(B) receptors in rat substantia nigra pars reticulata neurones
Title | Differential expression of pre- and postsynaptic GABA(B) receptors in rat substantia nigra pars reticulata neurones |
---|---|
Authors | |
Keywords | Baclofen Substantia nigra GABA(B) receptor |
Issue Date | 1998 |
Citation | European Journal of Pharmacology, 1998, v. 349, n. 2-3, p. 187-197 How to Cite? |
Abstract | Whole-cell recordings were made from substantia nigra pars reticulata in rat midbrain slices to study the functional expression of pre- and postsynaptic GABA(B) receptors in GABA output neurones. Baclofen (up to 300 μM) dose-dependently activated a weak current which was insensitive to tetrodotoxin and Ca -free solution but blocked by Ca and 2-OH-saclofen. The maximum current activated by baclofen (30 μM) was 43.0 ± 4.5 pA (n = 27), representing only 23% of that in dopamine neurones. Baclofen (1-30 μM) also reduced the frequency of the GABA(A) receptor-mediated miniature inhibitory postsynaptic currents while the distribution of their amplitudes was unaffected. This presynaptic effect of baclofen, prominent at a concentration as low as 1 μM, was sensitive to 2-OH-saclofen and occluded by Cd , but was unaffected by Ba . The results suggest a predominant role of the presynaptic GABA(B) receptors in substantia nigra pars reticulate. The relative abundance of pre- and postsynaptic GABA(B) receptor subtypes in this brain region may also be important in mediating the anticonvulsant effect of baclofen in rats. 2+ 2+ 2+ 2+ |
Persistent Identifier | http://hdl.handle.net/10722/298000 |
ISSN | 2023 Impact Factor: 4.2 2023 SCImago Journal Rankings: 1.055 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chan, Priscilla K.Y. | - |
dc.contributor.author | Leung, Chris K.S. | - |
dc.contributor.author | Yung, Wing Ho | - |
dc.date.accessioned | 2021-04-08T03:07:26Z | - |
dc.date.available | 2021-04-08T03:07:26Z | - |
dc.date.issued | 1998 | - |
dc.identifier.citation | European Journal of Pharmacology, 1998, v. 349, n. 2-3, p. 187-197 | - |
dc.identifier.issn | 0014-2999 | - |
dc.identifier.uri | http://hdl.handle.net/10722/298000 | - |
dc.description.abstract | Whole-cell recordings were made from substantia nigra pars reticulata in rat midbrain slices to study the functional expression of pre- and postsynaptic GABA(B) receptors in GABA output neurones. Baclofen (up to 300 μM) dose-dependently activated a weak current which was insensitive to tetrodotoxin and Ca -free solution but blocked by Ca and 2-OH-saclofen. The maximum current activated by baclofen (30 μM) was 43.0 ± 4.5 pA (n = 27), representing only 23% of that in dopamine neurones. Baclofen (1-30 μM) also reduced the frequency of the GABA(A) receptor-mediated miniature inhibitory postsynaptic currents while the distribution of their amplitudes was unaffected. This presynaptic effect of baclofen, prominent at a concentration as low as 1 μM, was sensitive to 2-OH-saclofen and occluded by Cd , but was unaffected by Ba . The results suggest a predominant role of the presynaptic GABA(B) receptors in substantia nigra pars reticulate. The relative abundance of pre- and postsynaptic GABA(B) receptor subtypes in this brain region may also be important in mediating the anticonvulsant effect of baclofen in rats. 2+ 2+ 2+ 2+ | - |
dc.language | eng | - |
dc.relation.ispartof | European Journal of Pharmacology | - |
dc.subject | Baclofen | - |
dc.subject | Substantia nigra | - |
dc.subject | GABA(B) receptor | - |
dc.title | Differential expression of pre- and postsynaptic GABA(B) receptors in rat substantia nigra pars reticulata neurones | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/S0014-2999(98)00194-0 | - |
dc.identifier.pmid | 9671097 | - |
dc.identifier.scopus | eid_2-s2.0-0032557469 | - |
dc.identifier.volume | 349 | - |
dc.identifier.issue | 2-3 | - |
dc.identifier.spage | 187 | - |
dc.identifier.epage | 197 | - |
dc.identifier.isi | WOS:000074286800008 | - |
dc.identifier.issnl | 0014-2999 | - |