File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Corpora Cavernos Invasion Vs. Corpus Spongiosum Invasion In Penile Cancer: A Systematic Review And Meta-analysis

TitleCorpora Cavernos Invasion Vs. Corpus Spongiosum Invasion In Penile Cancer: A Systematic Review And Meta-analysis
Authors
Keywordspenile cancer
prognosis
meta-analysis
lymph node metastasis
stage
Issue Date2021
PublisherIvyspring International Publisher. The Journal's web site is located at http://www.jcancer.org/
Citation
Journal of Cancer, 2021, v. 12 n. 7, p. 1960-1966 How to Cite?
AbstractObjective: Changes were made in the 8th edition of the American Joint Committee on Cancer (AJCC) staging system according to cavernosum invasion for penile squamous cell carcinoma. This study aimed to determine the difference of prognostic validity between corpora cavernosa (CC) invasion and corpus spongiosum (CS) invasion. Methods: In this study, we searched PubMed, Cochrane CENTRAL, and Embase to select English-language articles until July 15, 2020. Pooled analyses of hazard ratios (HRs) and odds ratios (ORs) were performed. Results: Eleven studies including 3692 cases were included in the final ananlysis (1431 cases with CC and 1360 cases with CS). According to the anatomical structure, the pooled results demonstrated that patients with CC invasion had a similar rate of LNM to those with CS invasion (OR 1.34, 95% confidence interval (CI) 0.97-1.86; P=0.076). However, patients with CC invasion had a higher rate of lymph node metastasis (LNM) than those with CS invasion according to the 8th edition tumor stage (OR 1.58, 95% CI 1.14-2.21; P<0.001). Regarding survival, patients with CS invasion obtained a significantly better cancer-specific survival (CSS) (HR, 0.67; 95% CI, 0.46-0.96; P=0.030), but not in overall survival (OS) (HR: 1.30; 95% CI, 0.52-3.20; P=0.585) than those with CC invasion. No a significant publication bias was observed by Begg's and Egger's tests. Conclusions: The systematic comparison suggests that patients with CS invasion had better CSS than those with CC invasion. CC invasion was associated with a high risk of LNM. The conclusions should be validated by large-scale studies.
Persistent Identifierhttp://hdl.handle.net/10722/297702
ISSN
2023 Impact Factor: 3.3
2023 SCImago Journal Rankings: 0.901
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLi, Z-
dc.contributor.authorLi, X-
dc.contributor.authorLam, W-
dc.contributor.authorCao, Y-
dc.contributor.authorGeng, J-
dc.contributor.authorOrnellas, AA-
dc.contributor.authorZhou, F-
dc.contributor.authorHan, H-
dc.date.accessioned2021-03-23T04:20:27Z-
dc.date.available2021-03-23T04:20:27Z-
dc.date.issued2021-
dc.identifier.citationJournal of Cancer, 2021, v. 12 n. 7, p. 1960-1966-
dc.identifier.issn1837-9664-
dc.identifier.urihttp://hdl.handle.net/10722/297702-
dc.description.abstractObjective: Changes were made in the 8th edition of the American Joint Committee on Cancer (AJCC) staging system according to cavernosum invasion for penile squamous cell carcinoma. This study aimed to determine the difference of prognostic validity between corpora cavernosa (CC) invasion and corpus spongiosum (CS) invasion. Methods: In this study, we searched PubMed, Cochrane CENTRAL, and Embase to select English-language articles until July 15, 2020. Pooled analyses of hazard ratios (HRs) and odds ratios (ORs) were performed. Results: Eleven studies including 3692 cases were included in the final ananlysis (1431 cases with CC and 1360 cases with CS). According to the anatomical structure, the pooled results demonstrated that patients with CC invasion had a similar rate of LNM to those with CS invasion (OR 1.34, 95% confidence interval (CI) 0.97-1.86; P=0.076). However, patients with CC invasion had a higher rate of lymph node metastasis (LNM) than those with CS invasion according to the 8th edition tumor stage (OR 1.58, 95% CI 1.14-2.21; P<0.001). Regarding survival, patients with CS invasion obtained a significantly better cancer-specific survival (CSS) (HR, 0.67; 95% CI, 0.46-0.96; P=0.030), but not in overall survival (OS) (HR: 1.30; 95% CI, 0.52-3.20; P=0.585) than those with CC invasion. No a significant publication bias was observed by Begg's and Egger's tests. Conclusions: The systematic comparison suggests that patients with CS invasion had better CSS than those with CC invasion. CC invasion was associated with a high risk of LNM. The conclusions should be validated by large-scale studies.-
dc.languageeng-
dc.publisherIvyspring International Publisher. The Journal's web site is located at http://www.jcancer.org/-
dc.relation.ispartofJournal of Cancer-
dc.rightsJournal of Cancer. Copyright © Ivyspring International Publisher.-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectpenile cancer-
dc.subjectprognosis-
dc.subjectmeta-analysis-
dc.subjectlymph node metastasis-
dc.subjectstage-
dc.titleCorpora Cavernos Invasion Vs. Corpus Spongiosum Invasion In Penile Cancer: A Systematic Review And Meta-analysis-
dc.typeArticle-
dc.identifier.emailLam, W: lamwayne@hku.hk-
dc.identifier.authorityLam, W=rp02305-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.7150/jca.56504-
dc.identifier.pmid33753994-
dc.identifier.pmcidPMC7974529-
dc.identifier.scopuseid_2-s2.0-85101673293-
dc.identifier.hkuros321782-
dc.identifier.volume12-
dc.identifier.issue7-
dc.identifier.spage1960-
dc.identifier.epage1966-
dc.identifier.isiWOS:000623069400011-
dc.publisher.placeAustralia-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats