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Article: Association between Bariatric Surgery and Risks of Cancer among Chinese Patients with Type 2 Diabetes Mellitus: A Retrospective Cohort Study

TitleAssociation between Bariatric Surgery and Risks of Cancer among Chinese Patients with Type 2 Diabetes Mellitus: A Retrospective Cohort Study
Authors
Keywordsbariatric surgery
cancer
mortality
obesity
type 2 diabetes
Issue Date2021
PublisherWiley-Blackwell Publishing, Inc. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=1753-0393
Citation
Journal of Diabetes, 2021, Epub 2021-03-17 How to Cite?
AbstractBackground: To examine risks of cancers, obesity‐related cancers (eg, including cancers in digestive organs, breast, ovary, kidney, thyroid, and myeloma), cancer‐related mortality, and all‐cause mortality in patients with type 2 diabetes mellitus (T2DM) and obesity who underwent bariatric surgery. Methods: A retrospective cohort of 1944 T2DM patients with obesity (345 bariatric surgery patients and 1599 matched controls) who were free of cancer from 2006 to 2017 was assembled. One‐to‐five propensity‐score matching followed by propensity‐score trimming was used to balance baseline covariates. Results: During a mean follow‐up period of 37 months, there are risks that 3.2%, 1.4%, 0.9%, and 3.2% of bariatric patients would occur cancer, obesity‐related cancer, cancer‐related mortality and all‐cause mortality, respectively. Surgical patients were found to have reduced incidence rates (IRs) of obesity‐related cancer (0.531/100 person‐years, 95% CI: 0.172‐1.238/100 person‐years) and cancer of breast and genital organs (0.394/100 person‐years, 95% CI: 0.048‐1.424/100 person‐years) than matched control patients, whose IRs for obesity‐related cancer and cancer of breast and genital organs are 0.627/100 person‐years (95% CI: 0.426‐0.889/100 person‐years) and 0.521/ 100 person‐years (95% CI: 0.277‐0.891/100 person‐years), respectively. Patients in surgical group had a significant reduction in risk of all‐cause mortality (Hazard ratio [HR] = 0.508, P = 0.041). Effects of bariatric surgery on any cancers (HR = 1.254, P = 0.510), obesity‐related cancers (HR = 0.843, P = 0.724) and cancer mortality (HR = 1.304, P = 0.694) were not significant. Conclusions: Bariatric surgery was not associated with risks of overall cancer, obesity‐related cancer and cancer mortality among T2DM patients with obesity at 3 years.
Persistent Identifierhttp://hdl.handle.net/10722/297639
ISSN
2020 Impact Factor: 4.006
2020 SCImago Journal Rankings: 0.949
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWei, YY-
dc.contributor.authorWong, SKH-
dc.contributor.authorWU, T-
dc.contributor.authorLaw, BTT-
dc.contributor.authorNg, EKW-
dc.contributor.authorLam, CLK-
dc.contributor.authorWong, CKH-
dc.date.accessioned2021-03-23T04:19:46Z-
dc.date.available2021-03-23T04:19:46Z-
dc.date.issued2021-
dc.identifier.citationJournal of Diabetes, 2021, Epub 2021-03-17-
dc.identifier.issn1753-0393-
dc.identifier.urihttp://hdl.handle.net/10722/297639-
dc.description.abstractBackground: To examine risks of cancers, obesity‐related cancers (eg, including cancers in digestive organs, breast, ovary, kidney, thyroid, and myeloma), cancer‐related mortality, and all‐cause mortality in patients with type 2 diabetes mellitus (T2DM) and obesity who underwent bariatric surgery. Methods: A retrospective cohort of 1944 T2DM patients with obesity (345 bariatric surgery patients and 1599 matched controls) who were free of cancer from 2006 to 2017 was assembled. One‐to‐five propensity‐score matching followed by propensity‐score trimming was used to balance baseline covariates. Results: During a mean follow‐up period of 37 months, there are risks that 3.2%, 1.4%, 0.9%, and 3.2% of bariatric patients would occur cancer, obesity‐related cancer, cancer‐related mortality and all‐cause mortality, respectively. Surgical patients were found to have reduced incidence rates (IRs) of obesity‐related cancer (0.531/100 person‐years, 95% CI: 0.172‐1.238/100 person‐years) and cancer of breast and genital organs (0.394/100 person‐years, 95% CI: 0.048‐1.424/100 person‐years) than matched control patients, whose IRs for obesity‐related cancer and cancer of breast and genital organs are 0.627/100 person‐years (95% CI: 0.426‐0.889/100 person‐years) and 0.521/ 100 person‐years (95% CI: 0.277‐0.891/100 person‐years), respectively. Patients in surgical group had a significant reduction in risk of all‐cause mortality (Hazard ratio [HR] = 0.508, P = 0.041). Effects of bariatric surgery on any cancers (HR = 1.254, P = 0.510), obesity‐related cancers (HR = 0.843, P = 0.724) and cancer mortality (HR = 1.304, P = 0.694) were not significant. Conclusions: Bariatric surgery was not associated with risks of overall cancer, obesity‐related cancer and cancer mortality among T2DM patients with obesity at 3 years.-
dc.languageeng-
dc.publisherWiley-Blackwell Publishing, Inc. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=1753-0393-
dc.relation.ispartofJournal of Diabetes-
dc.rightsSubmitted (preprint) Version This is the pre-peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. Accepted (peer-reviewed) Version This is the peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.-
dc.subjectbariatric surgery-
dc.subjectcancer-
dc.subjectmortality-
dc.subjectobesity-
dc.subjecttype 2 diabetes-
dc.titleAssociation between Bariatric Surgery and Risks of Cancer among Chinese Patients with Type 2 Diabetes Mellitus: A Retrospective Cohort Study-
dc.typeArticle-
dc.identifier.emailLaw, BTT: ttlaw@hku.hk-
dc.identifier.emailLam, CLK: clklam@hku.hk-
dc.identifier.emailWong, CKH: carlosho@hku.hk-
dc.identifier.authorityLam, CLK=rp00350-
dc.identifier.authorityWong, CKH=rp01931-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/1753-0407.13179-
dc.identifier.hkuros321914-
dc.identifier.volumeEpub 2021-03-17-
dc.identifier.isiWOS:000639774400001-
dc.publisher.placeUnited States-

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