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Article: A curcumin-sophorolipid nanocomplex inhibits Candida albicans filamentation and biofilm development

TitleA curcumin-sophorolipid nanocomplex inhibits Candida albicans filamentation and biofilm development
Authors
KeywordsBiofilm
Biosurfactant
Candida albicans
Curcumin
Filamentation
Issue Date2021
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/colsurfb
Citation
Colloids and Surfaces B: Biointerfaces, 2021, v. 200, p. article no. 111617 How to Cite?
AbstractCandida albicans is an opportunistic fungal pathogen that is highly resistant to contemporary antifungals, due to their biofilm lifestyle. The ability of C. albicans to invade human tissues is due to its filamentation. Therefore, inhibition of biofilms and filamentation of the yeast are high value targets to develop the next-generation antifungals. Curcumin (CU) is a natural polyphenol with excellent pharmacological attributes, but limitations such as poor solubility, acid, and enzyme tolerance have impeded its practical utility. Sophorolipids (SL) are biologically-derived surfactants that serve as efficient carriers of hydrophobic molecules such as curcumin into biofilms. Here, we synthesised a curcumin-sophorolipid nanocomplex (CUsingle bondSL), and comprehensively evaluated its effects on C. albicans biofilms and filamentation. Our results demonstrated that sub-inhibitory concentration of CUsingle bondSL (9.37 μg/mL) significantly inhibited fungal adhesion to substrates, and subsequent biofilm development, maturation, and filamentation. This effect was associated with significant downregulation of a select group of biofilm, adhesins, and hyphal regulatory genes. In conclusion, the curcumin-sophorolipid nanocomplex is a potent inhibitor of the two major virulence attributes of C. albicans, biofilm formation and filamentation, thus highlighting its promise as a putative anti-fungal agent with biofilm penetrative potential.
Persistent Identifierhttp://hdl.handle.net/10722/297628
ISSN
2023 Impact Factor: 5.4
2023 SCImago Journal Rankings: 0.910
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorRajasekar, V-
dc.contributor.authorDarne, P-
dc.contributor.authorPrabhune, A-
dc.contributor.authorKao, RYT-
dc.contributor.authorSolomon, AP-
dc.contributor.authorRamage, G-
dc.contributor.authorSamaranayake, L-
dc.contributor.authorNeelakantan, P-
dc.date.accessioned2021-03-23T04:19:37Z-
dc.date.available2021-03-23T04:19:37Z-
dc.date.issued2021-
dc.identifier.citationColloids and Surfaces B: Biointerfaces, 2021, v. 200, p. article no. 111617-
dc.identifier.issn0927-7765-
dc.identifier.urihttp://hdl.handle.net/10722/297628-
dc.description.abstractCandida albicans is an opportunistic fungal pathogen that is highly resistant to contemporary antifungals, due to their biofilm lifestyle. The ability of C. albicans to invade human tissues is due to its filamentation. Therefore, inhibition of biofilms and filamentation of the yeast are high value targets to develop the next-generation antifungals. Curcumin (CU) is a natural polyphenol with excellent pharmacological attributes, but limitations such as poor solubility, acid, and enzyme tolerance have impeded its practical utility. Sophorolipids (SL) are biologically-derived surfactants that serve as efficient carriers of hydrophobic molecules such as curcumin into biofilms. Here, we synthesised a curcumin-sophorolipid nanocomplex (CUsingle bondSL), and comprehensively evaluated its effects on C. albicans biofilms and filamentation. Our results demonstrated that sub-inhibitory concentration of CUsingle bondSL (9.37 μg/mL) significantly inhibited fungal adhesion to substrates, and subsequent biofilm development, maturation, and filamentation. This effect was associated with significant downregulation of a select group of biofilm, adhesins, and hyphal regulatory genes. In conclusion, the curcumin-sophorolipid nanocomplex is a potent inhibitor of the two major virulence attributes of C. albicans, biofilm formation and filamentation, thus highlighting its promise as a putative anti-fungal agent with biofilm penetrative potential.-
dc.languageeng-
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/colsurfb-
dc.relation.ispartofColloids and Surfaces B: Biointerfaces-
dc.subjectBiofilm-
dc.subjectBiosurfactant-
dc.subjectCandida albicans-
dc.subjectCurcumin-
dc.subjectFilamentation-
dc.titleA curcumin-sophorolipid nanocomplex inhibits Candida albicans filamentation and biofilm development-
dc.typeArticle-
dc.identifier.emailKao, RYT: rytkao@hkucc.hku.hk-
dc.identifier.emailNeelakantan, P: prasanna@hku.hk-
dc.identifier.authorityKao, RYT=rp00481-
dc.identifier.authorityNeelakantan, P=rp02214-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.colsurfb.2021.111617-
dc.identifier.pmid33592455-
dc.identifier.scopuseid_2-s2.0-85100730621-
dc.identifier.hkuros321773-
dc.identifier.volume200-
dc.identifier.spagearticle no. 111617-
dc.identifier.epagearticle no. 111617-
dc.identifier.isiWOS:000634560200006-
dc.publisher.placeNetherlands-

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