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Article: Synthesis and Antiviral Evaluation of New N-acylhydrazones Containing Glycine Residue

TitleSynthesis and Antiviral Evaluation of New N-acylhydrazones Containing Glycine Residue
Authors
Tian, BaoheHe, MeiziTan, ZhiwuTang, ShixingHewlett, IndiraChen, ShuguangJin, YinxueYang, Ming
KeywordsHIV-1 capsid assembly
Synthesis
N-acylhydrazone derivatives
Antiviral activity
Issue Date2011
Citation
Chemical Biology and Drug Design, 2011, v. 77, n. 3, p. 189-198 How to Cite?
DOI: http://dx.doi.org/10.1111/j.1747-0285.2010.01050.x
AbstractN-acylhydrazones containing glycine residue 3a-j and 8a-h were synthesized as HIV-1 capsid protein assembly inhibitors. The structures of the novel N-acylhydrazone derivatives were characterized using different spectroscopic methods. Antiviral activity demonstrated that compound 8c bearing 4-methylphenyl moiety was the most active with low cytotoxicity. © 2011 John Wiley & Sons A/S.
Persistent Identifierhttp://hdl.handle.net/10722/297306
ISSN
1747-0277
2021 Impact Factor: 2.873
2020 SCImago Journal Rankings: 0.590
ISI Accession Number ID
WOS:000287146200005

 

DC FieldValueLanguage
dc.contributor.authorTian, Baohe-
dc.contributor.authorHe, Meizi-
dc.contributor.authorTan, Zhiwu-
dc.contributor.authorTang, Shixing-
dc.contributor.authorHewlett, Indira-
dc.contributor.authorChen, Shuguang-
dc.contributor.authorJin, Yinxue-
dc.contributor.authorYang, Ming-
dc.date.accessioned2021-03-15T07:33:29Z-
dc.date.available2021-03-15T07:33:29Z-
dc.date.issued2011-
dc.identifier.citationChemical Biology and Drug Design, 2011, v. 77, n. 3, p. 189-198-
dc.identifier.issn1747-0277-
dc.identifier.urihttp://hdl.handle.net/10722/297306-
dc.description.abstractN-acylhydrazones containing glycine residue 3a-j and 8a-h were synthesized as HIV-1 capsid protein assembly inhibitors. The structures of the novel N-acylhydrazone derivatives were characterized using different spectroscopic methods. Antiviral activity demonstrated that compound 8c bearing 4-methylphenyl moiety was the most active with low cytotoxicity. © 2011 John Wiley & Sons A/S.-
dc.languageeng-
dc.relation.ispartofChemical Biology and Drug Design-
dc.subjectHIV-1 capsid assembly-
dc.subjectSynthesis-
dc.subjectN-acylhydrazone derivatives-
dc.subjectAntiviral activity-
dc.titleSynthesis and Antiviral Evaluation of New N-acylhydrazones Containing Glycine Residue-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1747-0285.2010.01050.x-
dc.identifier.pmid21306567-
dc.identifier.scopuseid_2-s2.0-79551710372-
dc.identifier.volume77-
dc.identifier.issue3-
dc.identifier.spage189-
dc.identifier.epage198-
dc.identifier.eissn1747-0285-
dc.identifier.isiWOS:000287146200005-
dc.identifier.issnl1747-0277-

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