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- Publisher Website: 10.1351/PAC-CON-09-01-04
- Scopus: eid_2-s2.0-76049109973
- WOS: WOS:000274709300030
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Conference Paper: Design, synthesis, and biological evaluation of novel substituted [1,2,3]triazolo[4,5-d]pyrimidines as HIV-1 Tat-TAR interaction inhibitors
Title | Design, synthesis, and biological evaluation of novel substituted [1,2,3]triazolo[4,5-d]pyrimidines as HIV-1 Tat-TAR interaction inhibitors |
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Authors | |
Keywords | Antiviral activities Heterocycle compounds TAR RNA Substituted purines HIV Tat-TAR inhibitors |
Issue Date | 2010 |
Citation | Pure and Applied Chemistry, 2010, v. 82, n. 1, p. 339-347 How to Cite? |
Abstract | A novel series of compounds, derived from [1, 2, 3]triazolo[4, 5-d]pyrimidines with a guanidyl group or amino group-terminated side chain was designed and synthesized as HIV-1 trans-activator of transcription-trans- activation responsive region (Tat-TAR) interaction inhibitors. Their ability to inhibit Tat-TAR RNA interaction was determined by a Tat-dependent HIV-1 long terminal repeat (LTR)-driven chloramphenicol acetyltransferase (CAT) assay and simian immunodeficiency virus (SIV)-induced syncytium evaluation. The binding of the compounds with TAR RNA was conducted by molecular modeling and capillary electrophoresis (CE) analysis. The results showed that all the compounds could block the Tat-TAR interaction and have antiviral activities. © 2010 IUPAC. |
Persistent Identifier | http://hdl.handle.net/10722/297303 |
ISSN | 2023 Impact Factor: 2.0 2023 SCImago Journal Rankings: 0.435 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Yu, Fei | - |
dc.contributor.author | Pang, Ruifang | - |
dc.contributor.author | Yuan, Dekai | - |
dc.contributor.author | He, Meizi | - |
dc.contributor.author | Zhang, Chunlei | - |
dc.contributor.author | Chen, Shuguang | - |
dc.contributor.author | Yang, Ming | - |
dc.date.accessioned | 2021-03-15T07:33:28Z | - |
dc.date.available | 2021-03-15T07:33:28Z | - |
dc.date.issued | 2010 | - |
dc.identifier.citation | Pure and Applied Chemistry, 2010, v. 82, n. 1, p. 339-347 | - |
dc.identifier.issn | 0033-4545 | - |
dc.identifier.uri | http://hdl.handle.net/10722/297303 | - |
dc.description.abstract | A novel series of compounds, derived from [1, 2, 3]triazolo[4, 5-d]pyrimidines with a guanidyl group or amino group-terminated side chain was designed and synthesized as HIV-1 trans-activator of transcription-trans- activation responsive region (Tat-TAR) interaction inhibitors. Their ability to inhibit Tat-TAR RNA interaction was determined by a Tat-dependent HIV-1 long terminal repeat (LTR)-driven chloramphenicol acetyltransferase (CAT) assay and simian immunodeficiency virus (SIV)-induced syncytium evaluation. The binding of the compounds with TAR RNA was conducted by molecular modeling and capillary electrophoresis (CE) analysis. The results showed that all the compounds could block the Tat-TAR interaction and have antiviral activities. © 2010 IUPAC. | - |
dc.language | eng | - |
dc.relation.ispartof | Pure and Applied Chemistry | - |
dc.subject | Antiviral activities | - |
dc.subject | Heterocycle compounds | - |
dc.subject | TAR RNA | - |
dc.subject | Substituted purines | - |
dc.subject | HIV | - |
dc.subject | Tat-TAR inhibitors | - |
dc.title | Design, synthesis, and biological evaluation of novel substituted [1,2,3]triazolo[4,5-d]pyrimidines as HIV-1 Tat-TAR interaction inhibitors | - |
dc.type | Conference_Paper | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1351/PAC-CON-09-01-04 | - |
dc.identifier.scopus | eid_2-s2.0-76049109973 | - |
dc.identifier.volume | 82 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 339 | - |
dc.identifier.epage | 347 | - |
dc.identifier.eissn | 1365-3075 | - |
dc.identifier.isi | WOS:000274709300030 | - |
dc.identifier.issnl | 0033-4545 | - |