File Download
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1002/ctm2.189
- PMID: 32997403
- WOS: WOS:000576525900006
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Insights into the prognosis of lipidomic dysregulation for death risk in patients with coronary artery disease
Title | Insights into the prognosis of lipidomic dysregulation for death risk in patients with coronary artery disease |
---|---|
Authors | |
Keywords | coronary artery disease death left ventricular remodeling long-chain polyunsaturated fatty acids risk stratification |
Issue Date | 2020 |
Publisher | Wiley Open Access: Creative Commons Attribution License. The Journal's web site is located at http://www.clintransmed.com |
Citation | Clinical and Translational Medicine, 2020, v. 10 n. 5, p. article no. e189 How to Cite? |
Abstract | Background Dyslipidaemia contributes to the progression of coronary artery disease (CAD) toward adverse outcomes. Plasma lipidomic measure may improve the prognostic performances of clinical endpoints of CAD. Our research is designed to identify the correlations between plasma lipid species and the risks of death, major adverse cardiovascular event (MACE) and left ventricular (LV) remodeling in patients with CAD. Methods A total of 1569 Chinese patients with CAD, 1011 single-centre patients as internal training cohort, and 558 multicentre patients as external validation cohort, were enrolled. The concentration of plasma lipids in both cohorts was determined through widely targeted lipidomic profiling. Least absolute shrinkage and selection operator Cox and multivariate Cox regressions were used to develop prognostic models for death and MACE, respectively. Results Ten (Cer(d18:1/20:1), Cer(d18:1/24:1), PE(30:2), PE(32:0), PE(32:2), PC(O-38:2), PC(O-36:4), PC(16:1/22:2), LPC(18:2/0:0) and LPE(0:0/24:6)) and two (Cer(d18:1/20:1) and LPC(20:0/0:0)) lipid species were independently related to death and MACE, respectively. Cer(d18:1/20:1) and Cer(d18:1/24:1) were correlated with LV remodeling (P < .05). The lipidic panel incorporating 10 lipid species and two traditional biomarkers for predicting 5-year death risk represented a remarkable higher discrimination than traditional model with increased area under the curve from 76.56 to 83.65%, continuous NRI of 0.634 and IDI of 0.131. Furthermore, the panel was successfully used in differentiating multicentre patients with low, middle, or high risks (P < .0001). Further analysis indicated that the number of double bonds of phosphatidyl choline and the content of carbon atoms of phosphatidyl ethanolamines were negatively associated with death risk. Conclusions Improvement in the prediction of death confirms the effectiveness of plasma lipids as predictors to risk classification in patients with CAD. The association between the structural characteristics of long-chain polyunsaturated fatty acids and death risk highlights the need for mechanistic research that characterizes the role of individual lipid species in disease pathogenesis. |
Persistent Identifier | http://hdl.handle.net/10722/296378 |
ISSN | 2023 Impact Factor: 7.9 2023 SCImago Journal Rankings: 2.424 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Qin, M | - |
dc.contributor.author | Zhu, Q | - |
dc.contributor.author | Lai, W | - |
dc.contributor.author | Ma, Q | - |
dc.contributor.author | Liu, C | - |
dc.contributor.author | Chen, X | - |
dc.contributor.author | Zhang, Y | - |
dc.contributor.author | Wang, Z | - |
dc.contributor.author | Chen, H | - |
dc.contributor.author | Yan, H | - |
dc.contributor.author | Lei, H | - |
dc.contributor.author | Zhang, S | - |
dc.contributor.author | Dong, X | - |
dc.contributor.author | Wang, H | - |
dc.contributor.author | Huang, M | - |
dc.contributor.author | Lian, Q | - |
dc.contributor.author | Zhong, S | - |
dc.date.accessioned | 2021-02-22T04:54:26Z | - |
dc.date.available | 2021-02-22T04:54:26Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Clinical and Translational Medicine, 2020, v. 10 n. 5, p. article no. e189 | - |
dc.identifier.issn | 2001-1326 | - |
dc.identifier.uri | http://hdl.handle.net/10722/296378 | - |
dc.description.abstract | Background Dyslipidaemia contributes to the progression of coronary artery disease (CAD) toward adverse outcomes. Plasma lipidomic measure may improve the prognostic performances of clinical endpoints of CAD. Our research is designed to identify the correlations between plasma lipid species and the risks of death, major adverse cardiovascular event (MACE) and left ventricular (LV) remodeling in patients with CAD. Methods A total of 1569 Chinese patients with CAD, 1011 single-centre patients as internal training cohort, and 558 multicentre patients as external validation cohort, were enrolled. The concentration of plasma lipids in both cohorts was determined through widely targeted lipidomic profiling. Least absolute shrinkage and selection operator Cox and multivariate Cox regressions were used to develop prognostic models for death and MACE, respectively. Results Ten (Cer(d18:1/20:1), Cer(d18:1/24:1), PE(30:2), PE(32:0), PE(32:2), PC(O-38:2), PC(O-36:4), PC(16:1/22:2), LPC(18:2/0:0) and LPE(0:0/24:6)) and two (Cer(d18:1/20:1) and LPC(20:0/0:0)) lipid species were independently related to death and MACE, respectively. Cer(d18:1/20:1) and Cer(d18:1/24:1) were correlated with LV remodeling (P < .05). The lipidic panel incorporating 10 lipid species and two traditional biomarkers for predicting 5-year death risk represented a remarkable higher discrimination than traditional model with increased area under the curve from 76.56 to 83.65%, continuous NRI of 0.634 and IDI of 0.131. Furthermore, the panel was successfully used in differentiating multicentre patients with low, middle, or high risks (P < .0001). Further analysis indicated that the number of double bonds of phosphatidyl choline and the content of carbon atoms of phosphatidyl ethanolamines were negatively associated with death risk. Conclusions Improvement in the prediction of death confirms the effectiveness of plasma lipids as predictors to risk classification in patients with CAD. The association between the structural characteristics of long-chain polyunsaturated fatty acids and death risk highlights the need for mechanistic research that characterizes the role of individual lipid species in disease pathogenesis. | - |
dc.language | eng | - |
dc.publisher | Wiley Open Access: Creative Commons Attribution License. The Journal's web site is located at http://www.clintransmed.com | - |
dc.relation.ispartof | Clinical and Translational Medicine | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | coronary artery disease | - |
dc.subject | death | - |
dc.subject | left ventricular remodeling | - |
dc.subject | long-chain polyunsaturated fatty acids | - |
dc.subject | risk stratification | - |
dc.title | Insights into the prognosis of lipidomic dysregulation for death risk in patients with coronary artery disease | - |
dc.type | Article | - |
dc.identifier.email | Lian, Q: qzlian@hkucc.hku.hk | - |
dc.identifier.authority | Lian, Q=rp00267 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1002/ctm2.189 | - |
dc.identifier.pmid | 32997403 | - |
dc.identifier.pmcid | PMC7522592 | - |
dc.identifier.hkuros | 321287 | - |
dc.identifier.volume | 10 | - |
dc.identifier.issue | 5 | - |
dc.identifier.spage | article no. e189 | - |
dc.identifier.epage | article no. e189 | - |
dc.identifier.isi | WOS:000576525900006 | - |
dc.publisher.place | United Kingdom | - |