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Article: Lifestyle Medicine for Depression: A Meta-Analysis of Randomized Controlled Trials

TitleLifestyle Medicine for Depression: A Meta-Analysis of Randomized Controlled Trials
Authors
KeywordsLifestyle
Depression
Effectiveness
Meta-analysis
Randomized controlled trial AC
Issue Date2021
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jad
Citation
Journal of Affective Disorders, 2021, v. 284, p. 203-216 How to Cite?
AbstractBackground: The treatment effect of multi-component LM interventions on depressive symptoms has not yet been examined. Methods: We systematically searched six databases from inception to February 2020 to identify randomized controlled trials (RCTs) involving any multi-component LM interventions (physical activity, nutritional advice, sleep management, and/or stress management) on depressive symptoms relative to care as usual (CAU), waitlist (WL), no intervention (NI), or attention control (AC) comparisons. Results: Fifty studies with 8,479 participants were included. Multi-component LM interventions reduced depressive symptoms significantly relative to the CAU (p >.001; d = 0.20) and WL/NI (p > .01; d = 0.22) comparisons at immediate posttreatment. However, no significant difference was found when compared with AC. The intervention effects were maintained in the short-term (1- to 3-month follow-up) relative to the CAU comparison (p > .05; d = 0.25), but not in the medium- and long-term. The moderator analyses examining the effect of multi-component LM interventions compared with CAU suggested that the number of lifestyle factors adopted was a significant moderator. Although disease type was not a significant moderator, there was a tendency that the clinical effect of multi-component LM interventions was stronger (d = 0.45) in those diagnosed with major depression. No publication bias was detected. Limitations: Low number of RCTs available in some subgroup analyses prevented from finding meaningful effects. Results may not be extended to major depression, because data on secondary depression were captured. Conclusion: Multi-component LM interventions appeared to be effective in mitigating depressive symptoms; however, the magnitude of the clinical effect was small. Future research is needed to assess more comprehensive and individualized LM interventions which have a greater emphasis on motivational and compliance aspects and focus solely on individuals with depression.
Persistent Identifierhttp://hdl.handle.net/10722/296339
ISSN
2023 Impact Factor: 4.9
2023 SCImago Journal Rankings: 2.082
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWong, VWH-
dc.contributor.authorHo, FYY-
dc.contributor.authorShi, NK-
dc.contributor.authorSarris, J-
dc.contributor.authorChung, KF-
dc.contributor.authorYeung, WF-
dc.date.accessioned2021-02-22T04:53:53Z-
dc.date.available2021-02-22T04:53:53Z-
dc.date.issued2021-
dc.identifier.citationJournal of Affective Disorders, 2021, v. 284, p. 203-216-
dc.identifier.issn0165-0327-
dc.identifier.urihttp://hdl.handle.net/10722/296339-
dc.description.abstractBackground: The treatment effect of multi-component LM interventions on depressive symptoms has not yet been examined. Methods: We systematically searched six databases from inception to February 2020 to identify randomized controlled trials (RCTs) involving any multi-component LM interventions (physical activity, nutritional advice, sleep management, and/or stress management) on depressive symptoms relative to care as usual (CAU), waitlist (WL), no intervention (NI), or attention control (AC) comparisons. Results: Fifty studies with 8,479 participants were included. Multi-component LM interventions reduced depressive symptoms significantly relative to the CAU (p >.001; d = 0.20) and WL/NI (p > .01; d = 0.22) comparisons at immediate posttreatment. However, no significant difference was found when compared with AC. The intervention effects were maintained in the short-term (1- to 3-month follow-up) relative to the CAU comparison (p > .05; d = 0.25), but not in the medium- and long-term. The moderator analyses examining the effect of multi-component LM interventions compared with CAU suggested that the number of lifestyle factors adopted was a significant moderator. Although disease type was not a significant moderator, there was a tendency that the clinical effect of multi-component LM interventions was stronger (d = 0.45) in those diagnosed with major depression. No publication bias was detected. Limitations: Low number of RCTs available in some subgroup analyses prevented from finding meaningful effects. Results may not be extended to major depression, because data on secondary depression were captured. Conclusion: Multi-component LM interventions appeared to be effective in mitigating depressive symptoms; however, the magnitude of the clinical effect was small. Future research is needed to assess more comprehensive and individualized LM interventions which have a greater emphasis on motivational and compliance aspects and focus solely on individuals with depression.-
dc.languageeng-
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jad-
dc.relation.ispartofJournal of Affective Disorders-
dc.subjectLifestyle-
dc.subjectDepression-
dc.subjectEffectiveness-
dc.subjectMeta-analysis-
dc.subjectRandomized controlled trial AC-
dc.titleLifestyle Medicine for Depression: A Meta-Analysis of Randomized Controlled Trials-
dc.typeArticle-
dc.identifier.emailChung, KF: kfchung@hku.hk-
dc.identifier.authorityChung, KF=rp00377-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.jad.2021.02.012-
dc.identifier.scopuseid_2-s2.0-85101329449-
dc.identifier.hkuros321345-
dc.identifier.volume284-
dc.identifier.spage203-
dc.identifier.epage216-
dc.identifier.isiWOS:000623621400025-
dc.publisher.placeNetherlands-

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