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Article: APOE ε4 and the Influence of Sex, Age, Vascular Risk Factors, and Ethnicity on Cognitive Decline

TitleAPOE ε4 and the Influence of Sex, Age, Vascular Risk Factors, and Ethnicity on Cognitive Decline
Authors
KeywordsCognitive decline
APOE genotype
Epidemiology
Sex
Ethnicity
Issue Date2020
PublisherOxford University Press. The Journal's web site is located at http://biomed.gerontologyjournals.org/
Citation
Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 2020, v. 75 n. 10, p. 1863-1873 How to Cite?
AbstractWe aimed to examine the relationship between Apolipoprotein E epsilon 4 (APOE*4) carriage on cognitive decline, and whether these associations were moderated by sex, baseline age, ethnicity, and vascular risk factors. Participants were 19,225 individuals aged 54-103 years from 15 longitudinal cohort studies with a mean follow-up duration ranging between 1.2 and 10.7 years. Two-step individual participant data meta-analysis was used to pool results of study-wise analyses predicting memory and general cognitive decline from carriage of one or two APOE*4 alleles, and moderation of these associations by age, sex, vascular risk factors, and ethnicity. Separate pooled estimates were calculated in both men and women who were younger (ie, 62 years) and older (ie, 80 years) at baseline. Results showed that APOE*4 carriage was related to faster general cognitive decline in women, and faster memory decline in men. A stronger dose-dependent effect was observed in older men, with faster general cognitive and memory decline in those carrying two versus one APOE*4 allele. Vascular risk factors were related to an increased effect of APOE*4 on memory decline in younger women, but a weaker effect of APOE*4 on general cognitive decline in older men. The relationship between APOE*4 carriage and memory decline was larger in older-aged Asians than Whites. In sum, APOE*4 is related to cognitive decline in men and women, although these effects are enhanced by age and carriage of two APOE*4 alleles in men, a higher numbers of vascular risk factors during the early stages of late adulthood in women, and Asian ethnicity.
DescriptionFor Cohort Studies of Memory in an International Consortium (COSMIC)
Persistent Identifierhttp://hdl.handle.net/10722/296338
ISSN
2023 Impact Factor: 4.3
2023 SCImago Journal Rankings: 1.285
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorMakkar, SR-
dc.contributor.authorLipnicki, DM-
dc.contributor.authorCrawford, JD-
dc.contributor.authorKochan, NA-
dc.contributor.authorCastro-Costa, E-
dc.contributor.authorLima-Costa, MF-
dc.contributor.authorDiniz, BS-
dc.contributor.authorBrayne, C-
dc.contributor.authorStephan, B-
dc.contributor.authorMatthews, F-
dc.contributor.authorLlibre-Rodriguez, JJ-
dc.contributor.authorLlibre-Guerra, JJ-
dc.contributor.authorValhuerdi-Cepero, AJ-
dc.contributor.authorLipton, RB-
dc.contributor.authorKatz, MJ-
dc.contributor.authorWang, C-
dc.contributor.authorRitchie, K-
dc.contributor.authorCarles, S-
dc.contributor.authorCarriere, I-
dc.contributor.authorScarmeas, N-
dc.contributor.authorYannakoulia, M-
dc.contributor.authorKosmidis, M-
dc.contributor.authorLam, L-
dc.contributor.authorChan, WC-
dc.contributor.authorFung, A-
dc.contributor.authorGuaita, A-
dc.contributor.authorVaccaro, R-
dc.contributor.authorDavin, A-
dc.contributor.authorKim, KW-
dc.contributor.authorHan, JW-
dc.contributor.authorSuh, SW-
dc.contributor.authorRiedel-Heller, SG-
dc.contributor.authorRoehr, S-
dc.contributor.authorPabst, A-
dc.contributor.authorGanguli, M-
dc.contributor.authorHughes, TF-
dc.contributor.authorSnitz, B-
dc.contributor.authorAnstey, KJ-
dc.contributor.authorCherbuin, N-
dc.contributor.authorEasteal, S-
dc.contributor.authorHaan, MN-
dc.contributor.authorAiello, AE-
dc.contributor.authorDang, K-
dc.contributor.authorPin Ng, T-
dc.contributor.authorGao, Q-
dc.contributor.authorZin Nyunt, MS-
dc.contributor.authorBrodaty, H-
dc.contributor.authorTrollor, JN-
dc.contributor.authorLeung, Y-
dc.contributor.authorLo, JW-
dc.contributor.authorSachdev, P-
dc.contributor.authorLe Couteur, D-
dc.date.accessioned2021-02-22T04:53:52Z-
dc.date.available2021-02-22T04:53:52Z-
dc.date.issued2020-
dc.identifier.citationJournals of Gerontology Series A: Biological Sciences and Medical Sciences, 2020, v. 75 n. 10, p. 1863-1873-
dc.identifier.issn1079-5006-
dc.identifier.urihttp://hdl.handle.net/10722/296338-
dc.descriptionFor Cohort Studies of Memory in an International Consortium (COSMIC)-
dc.description.abstractWe aimed to examine the relationship between Apolipoprotein E epsilon 4 (APOE*4) carriage on cognitive decline, and whether these associations were moderated by sex, baseline age, ethnicity, and vascular risk factors. Participants were 19,225 individuals aged 54-103 years from 15 longitudinal cohort studies with a mean follow-up duration ranging between 1.2 and 10.7 years. Two-step individual participant data meta-analysis was used to pool results of study-wise analyses predicting memory and general cognitive decline from carriage of one or two APOE*4 alleles, and moderation of these associations by age, sex, vascular risk factors, and ethnicity. Separate pooled estimates were calculated in both men and women who were younger (ie, 62 years) and older (ie, 80 years) at baseline. Results showed that APOE*4 carriage was related to faster general cognitive decline in women, and faster memory decline in men. A stronger dose-dependent effect was observed in older men, with faster general cognitive and memory decline in those carrying two versus one APOE*4 allele. Vascular risk factors were related to an increased effect of APOE*4 on memory decline in younger women, but a weaker effect of APOE*4 on general cognitive decline in older men. The relationship between APOE*4 carriage and memory decline was larger in older-aged Asians than Whites. In sum, APOE*4 is related to cognitive decline in men and women, although these effects are enhanced by age and carriage of two APOE*4 alleles in men, a higher numbers of vascular risk factors during the early stages of late adulthood in women, and Asian ethnicity.-
dc.languageeng-
dc.publisherOxford University Press. The Journal's web site is located at http://biomed.gerontologyjournals.org/-
dc.relation.ispartofJournals of Gerontology Series A: Biological Sciences and Medical Sciences-
dc.rightsPost-print: This is a pre-copy-editing, author-produced PDF of an article accepted for publication in [insert journal title] following peer review. The definitive publisher-authenticated version [insert complete citation information here] is available online at: xxxxxxx [insert URL that the author will receive upon publication here]. -
dc.subjectCognitive decline-
dc.subjectAPOE genotype-
dc.subjectEpidemiology-
dc.subjectSex-
dc.subjectEthnicity-
dc.titleAPOE ε4 and the Influence of Sex, Age, Vascular Risk Factors, and Ethnicity on Cognitive Decline-
dc.typeArticle-
dc.identifier.emailChan, WC: waicchan@hku.hk-
dc.identifier.authorityChan, WC=rp01687-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1093/gerona/glaa116-
dc.identifier.pmid32396611-
dc.identifier.pmcidPMC7518559-
dc.identifier.scopuseid_2-s2.0-85087430028-
dc.identifier.hkuros321330-
dc.identifier.volume75-
dc.identifier.issue10-
dc.identifier.spage1863-
dc.identifier.epage1873-
dc.identifier.isiWOS:000579867400017-
dc.publisher.placeUnited States-

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