File Download
Supplementary
-
Citations:
- Appears in Collections:
Article: mGlu5: A double-edged sword for aversive learning related therapeutics
Title | mGlu5: A double-edged sword for aversive learning related therapeutics |
---|---|
Authors | |
Keywords | mGlu5 Learning and Memory Aversive Learning Fear Conditioning |
Issue Date | 2021 |
Publisher | Episteme Health Inc. The Journal's web site is located at https://epistemehealth.com/index.php/nab |
Citation | Neuroanatomy and Behaviour, 2021, v. 3, p. article no. e16 How to Cite? |
Abstract | Aversive memories underlie many types of anxiety disorders. One area of research to more effectively treat anxiety disorders has therefore been identifying pharmacological targets to affect memory processes. Among these targets, the metabotropic glutamate 5 receptor (mGlu5) has received attention due to the availability of drugs to utilize its role in learning and memory. In this review, we highlight preclinical studies examining the role of mGlu5 at various stages of aversive learning and its inhibition via extinction in order to gain a better understanding of its therapeutic potential. We suggest that mGlu5 has distinct roles at different stages of memory that not only makes it a tricky target, but a double-edged sword as a therapeutic. However, the selective involvement of mGlu5 in different memory stages allows for certain precision that could be harnessed clinically. We therefore suggest potential applications, limitations, and pitfalls when considering use of mGlu5 modulators as therapeutics. In addition, we recommend future studies to address important gaps in this literature, such as sex and age factors in light of anxiety disorders being more prevalent in those demographics. |
Persistent Identifier | http://hdl.handle.net/10722/295896 |
ISSN |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | TAN, SZK | - |
dc.contributor.author | Kim, JH | - |
dc.date.accessioned | 2021-02-08T08:15:34Z | - |
dc.date.available | 2021-02-08T08:15:34Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Neuroanatomy and Behaviour, 2021, v. 3, p. article no. e16 | - |
dc.identifier.issn | 2652-1768 | - |
dc.identifier.uri | http://hdl.handle.net/10722/295896 | - |
dc.description.abstract | Aversive memories underlie many types of anxiety disorders. One area of research to more effectively treat anxiety disorders has therefore been identifying pharmacological targets to affect memory processes. Among these targets, the metabotropic glutamate 5 receptor (mGlu5) has received attention due to the availability of drugs to utilize its role in learning and memory. In this review, we highlight preclinical studies examining the role of mGlu5 at various stages of aversive learning and its inhibition via extinction in order to gain a better understanding of its therapeutic potential. We suggest that mGlu5 has distinct roles at different stages of memory that not only makes it a tricky target, but a double-edged sword as a therapeutic. However, the selective involvement of mGlu5 in different memory stages allows for certain precision that could be harnessed clinically. We therefore suggest potential applications, limitations, and pitfalls when considering use of mGlu5 modulators as therapeutics. In addition, we recommend future studies to address important gaps in this literature, such as sex and age factors in light of anxiety disorders being more prevalent in those demographics. | - |
dc.language | eng | - |
dc.publisher | Episteme Health Inc. The Journal's web site is located at https://epistemehealth.com/index.php/nab | - |
dc.relation.ispartof | Neuroanatomy and Behaviour | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | mGlu5 | - |
dc.subject | Learning and Memory | - |
dc.subject | Aversive Learning | - |
dc.subject | Fear Conditioning | - |
dc.title | mGlu5: A double-edged sword for aversive learning related therapeutics | - |
dc.type | Article | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.35430/nab.2021.e16 | - |
dc.identifier.hkuros | 321071 | - |
dc.identifier.volume | 3 | - |
dc.identifier.spage | article no. e16 | - |
dc.identifier.epage | article no. e16 | - |
dc.publisher.place | Australia | - |