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Article: Natural products in drug discovery: advances and opportunities

TitleNatural products in drug discovery: advances and opportunities
Authors
Issue Date2021
PublisherNature Research: Nature Reviews Journals. The Journal's web site is located at http://www.nature.com/nrd/
Citation
Nature Reviews Drug Discovery, 2021, v. 20, p. 200-216 How to Cite?
AbstractNatural products and their structural analogues have historically made a major contribution to pharmacotherapy, especially for cancer and infectious diseases. Nevertheless, natural products also present challenges for drug discovery, such as technical barriers to screening, isolation, characterization and optimization, which contributed to a decline in their pursuit by the pharmaceutical industry from the 1990s onwards. In recent years, several technological and scientific developments — including improved analytical tools, genome mining and engineering strategies, and microbial culturing advances — are addressing such challenges and opening up new opportunities. Consequently, interest in natural products as drug leads is being revitalized, particularly for tackling antimicrobial resistance. Here, we summarize recent technological developments that are enabling natural product-based drug discovery, highlight selected applications and discuss key opportunities.
DescriptionBronze open access
Persistent Identifierhttp://hdl.handle.net/10722/295778
ISSN
2023 Impact Factor: 122.7
2023 SCImago Journal Rankings: 22.399
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorAtanasov, AG-
dc.contributor.authorZotchev, SB-
dc.contributor.authorDirsch, VM-
dc.contributor.authorThe International Natural Product Sciences Taskforce-
dc.contributor.authorYeung, AWK-
dc.contributor.authorSupuran, CT-
dc.date.accessioned2021-02-08T08:13:53Z-
dc.date.available2021-02-08T08:13:53Z-
dc.date.issued2021-
dc.identifier.citationNature Reviews Drug Discovery, 2021, v. 20, p. 200-216-
dc.identifier.issn1474-1776-
dc.identifier.urihttp://hdl.handle.net/10722/295778-
dc.descriptionBronze open access-
dc.description.abstractNatural products and their structural analogues have historically made a major contribution to pharmacotherapy, especially for cancer and infectious diseases. Nevertheless, natural products also present challenges for drug discovery, such as technical barriers to screening, isolation, characterization and optimization, which contributed to a decline in their pursuit by the pharmaceutical industry from the 1990s onwards. In recent years, several technological and scientific developments — including improved analytical tools, genome mining and engineering strategies, and microbial culturing advances — are addressing such challenges and opening up new opportunities. Consequently, interest in natural products as drug leads is being revitalized, particularly for tackling antimicrobial resistance. Here, we summarize recent technological developments that are enabling natural product-based drug discovery, highlight selected applications and discuss key opportunities.-
dc.languageeng-
dc.publisherNature Research: Nature Reviews Journals. The Journal's web site is located at http://www.nature.com/nrd/-
dc.relation.ispartofNature Reviews Drug Discovery-
dc.titleNatural products in drug discovery: advances and opportunities-
dc.typeArticle-
dc.identifier.emailYeung, AWK: ndyeung@hku.hk-
dc.identifier.authorityYeung, AWK=rp02143-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1038/s41573-020-00114-z-
dc.identifier.scopuseid_2-s2.0-85099930912-
dc.identifier.hkuros321196-
dc.identifier.volume20-
dc.identifier.spage200-
dc.identifier.epage216-
dc.identifier.isiWOS:000612711300001-
dc.publisher.placeUnited Kingdom-

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