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- Publisher Website: 10.1038/s41598-020-76016-2
- Scopus: eid_2-s2.0-85094918043
- PMID: 33144642
- WOS: WOS:000587349400023
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Article: Population genetic portrait of Pakistani Lahore-Christians based on 32 STR loci
Title | Population genetic portrait of Pakistani Lahore-Christians based on 32 STR loci |
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Authors | |
Issue Date | 2020 |
Publisher | Nature Research: Fully open access journals. The Journal's web site is located at http://www.nature.com/srep/index.html |
Citation | Scientific Reports, 2020, v. 10 n. 1, p. article no. 18960 How to Cite? |
Abstract | Phylogenetic relationship and the population structure of 500 individuals from the Christian community of Lahore, Pakistan, were examined based on 15 autosomal short tandem repeats (STRs) using the AmpFlSTR Identifiler Plus PCR Amplification Kit and our previously published Y-filer kit data (17 Y-STRs) of same samples. A total of 147 alleles were observed in 15 loci and allele 11 at the TPOX locus was the most frequent with frequency value (0.464). The data revealed that the Christian population has unique genetic characteristics with respect to a few unusual alleles and their frequencies relative to the other Pakistani population. Significant deviations from Hardy-Weinberg equilibrium were found at two loci (D13S317, D18S51) after Boneferroni's correction (p = 0.003). The combined power of discrimination, combined power of exclusion and cumulative probability of matching were 0.999999999999999978430815060354, 0.999995039393942 and 2.15692 x 10(-1)7, respectively. On the bases of genetic distances, PCA, phylogenetic and structure analysis Lahore-Christians appeared genetically more associated to south Asian particularly Indian populations like Tamil, Karnataka, Kerala and Andhra Pradesh than rest of global populations. |
Persistent Identifier | http://hdl.handle.net/10722/295773 |
ISSN | 2023 Impact Factor: 3.8 2023 SCImago Journal Rankings: 0.900 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Rubab, A | - |
dc.contributor.author | Shafique, M | - |
dc.contributor.author | Javed, F | - |
dc.contributor.author | Saleem, S | - |
dc.contributor.author | ZAHRA, FT | - |
dc.contributor.author | McNevin, D | - |
dc.contributor.author | Shahid, AA | - |
dc.date.accessioned | 2021-02-08T08:13:48Z | - |
dc.date.available | 2021-02-08T08:13:48Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Scientific Reports, 2020, v. 10 n. 1, p. article no. 18960 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | http://hdl.handle.net/10722/295773 | - |
dc.description.abstract | Phylogenetic relationship and the population structure of 500 individuals from the Christian community of Lahore, Pakistan, were examined based on 15 autosomal short tandem repeats (STRs) using the AmpFlSTR Identifiler Plus PCR Amplification Kit and our previously published Y-filer kit data (17 Y-STRs) of same samples. A total of 147 alleles were observed in 15 loci and allele 11 at the TPOX locus was the most frequent with frequency value (0.464). The data revealed that the Christian population has unique genetic characteristics with respect to a few unusual alleles and their frequencies relative to the other Pakistani population. Significant deviations from Hardy-Weinberg equilibrium were found at two loci (D13S317, D18S51) after Boneferroni's correction (p = 0.003). The combined power of discrimination, combined power of exclusion and cumulative probability of matching were 0.999999999999999978430815060354, 0.999995039393942 and 2.15692 x 10(-1)7, respectively. On the bases of genetic distances, PCA, phylogenetic and structure analysis Lahore-Christians appeared genetically more associated to south Asian particularly Indian populations like Tamil, Karnataka, Kerala and Andhra Pradesh than rest of global populations. | - |
dc.language | eng | - |
dc.publisher | Nature Research: Fully open access journals. The Journal's web site is located at http://www.nature.com/srep/index.html | - |
dc.relation.ispartof | Scientific Reports | - |
dc.rights | Scientific Reports. Copyright © Nature Research: Fully open access journals. | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.title | Population genetic portrait of Pakistani Lahore-Christians based on 32 STR loci | - |
dc.type | Article | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1038/s41598-020-76016-2 | - |
dc.identifier.pmid | 33144642 | - |
dc.identifier.pmcid | PMC7609739 | - |
dc.identifier.scopus | eid_2-s2.0-85094918043 | - |
dc.identifier.hkuros | 321225 | - |
dc.identifier.volume | 10 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | article no. 18960 | - |
dc.identifier.epage | article no. 18960 | - |
dc.identifier.isi | WOS:000587349400023 | - |
dc.publisher.place | United Kingdom | - |