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- Publisher Website: 10.1016/j.jhazmat.2020.124915
- Scopus: eid_2-s2.0-85098849234
- PMID: 33422758
- WOS: WOS:000621656800004
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Article: A critical review on genotoxicity potential of low dimensional nanomaterials
Title | A critical review on genotoxicity potential of low dimensional nanomaterials |
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Authors | |
Keywords | Low dimensional nanomaterials Comparative genotoxic potential Genotoxicity assay Carbon-based nanomaterials Inorganic metal-based nanomaterials |
Issue Date | 2021 |
Publisher | Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jhazmat |
Citation | Journal of Hazardous Materials, 2021, v. 409, p. article no. 124915 How to Cite? |
Abstract | Low dimensional nanomaterials (LDNMs) have earned attention among researchers as they exhibit a larger surface area to volume and quantum confinement effect compared to high dimensional nanomaterials. LDNMs, including 0-D and 1-D, possess several beneficial biomedical properties such as bioimaging, sensor, cosmetic, drug delivery, and cancer tumors ablation. However, they threaten human beings with the adverse effects of cytotoxicity, carcinogenicity, and genotoxicity when exposed for a prolonged time in industry or laboratory. Among different toxicities, genotoxicity must be taken into consideration with utmost importance as they inherit DNA related disorders causing congenital disabilities and malignancy to human beings. Many researchers have performed NMs’ genotoxicity using various cell lines and animal models and reported the effect on various physicochemical and biological factors. In the present work, we have compiled a comparative study on the genotoxicity of the same or different kinds of NMs. Notwithstanding, we have included the classification of genotoxicity, mechanism, assessment, and affecting factors. Further, we have highlighted the importance of studying the genotoxicity of LDNMs and signified the perceptions, future challenges, and possible directives in the field. |
Persistent Identifier | http://hdl.handle.net/10722/295521 |
ISSN | 2023 Impact Factor: 12.2 2023 SCImago Journal Rankings: 2.950 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Raja, IS | - |
dc.contributor.author | Lee, JH | - |
dc.contributor.author | Hong, SW | - |
dc.contributor.author | Shin, DM | - |
dc.contributor.author | Lee, JH | - |
dc.contributor.author | Han, DW | - |
dc.date.accessioned | 2021-01-25T11:16:03Z | - |
dc.date.available | 2021-01-25T11:16:03Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Journal of Hazardous Materials, 2021, v. 409, p. article no. 124915 | - |
dc.identifier.issn | 0304-3894 | - |
dc.identifier.uri | http://hdl.handle.net/10722/295521 | - |
dc.description.abstract | Low dimensional nanomaterials (LDNMs) have earned attention among researchers as they exhibit a larger surface area to volume and quantum confinement effect compared to high dimensional nanomaterials. LDNMs, including 0-D and 1-D, possess several beneficial biomedical properties such as bioimaging, sensor, cosmetic, drug delivery, and cancer tumors ablation. However, they threaten human beings with the adverse effects of cytotoxicity, carcinogenicity, and genotoxicity when exposed for a prolonged time in industry or laboratory. Among different toxicities, genotoxicity must be taken into consideration with utmost importance as they inherit DNA related disorders causing congenital disabilities and malignancy to human beings. Many researchers have performed NMs’ genotoxicity using various cell lines and animal models and reported the effect on various physicochemical and biological factors. In the present work, we have compiled a comparative study on the genotoxicity of the same or different kinds of NMs. Notwithstanding, we have included the classification of genotoxicity, mechanism, assessment, and affecting factors. Further, we have highlighted the importance of studying the genotoxicity of LDNMs and signified the perceptions, future challenges, and possible directives in the field. | - |
dc.language | eng | - |
dc.publisher | Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/jhazmat | - |
dc.relation.ispartof | Journal of Hazardous Materials | - |
dc.subject | Low dimensional nanomaterials | - |
dc.subject | Comparative genotoxic potential | - |
dc.subject | Genotoxicity assay | - |
dc.subject | Carbon-based nanomaterials | - |
dc.subject | Inorganic metal-based nanomaterials | - |
dc.title | A critical review on genotoxicity potential of low dimensional nanomaterials | - |
dc.type | Article | - |
dc.identifier.email | Shin, DM: dmshin@hku.hk | - |
dc.identifier.authority | Shin, DM=rp02569 | - |
dc.identifier.doi | 10.1016/j.jhazmat.2020.124915 | - |
dc.identifier.pmid | 33422758 | - |
dc.identifier.scopus | eid_2-s2.0-85098849234 | - |
dc.identifier.hkuros | 321014 | - |
dc.identifier.volume | 409 | - |
dc.identifier.spage | article no. 124915 | - |
dc.identifier.epage | article no. 124915 | - |
dc.identifier.isi | WOS:000621656800004 | - |
dc.publisher.place | Netherlands | - |