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Article: Microengineered poly(HEMA) hydrogels for wearable contact lens biosensing

TitleMicroengineered poly(HEMA) hydrogels for wearable contact lens biosensing
Authors
Issue Date2020
Citation
Lab on a Chip, 2020, v. 20, n. 22, p. 4205-4214 How to Cite?
Abstract© 2020 The Royal Society of Chemistry. Microchannels in hydrogels play an essential role in enabling a smart contact lens. However, microchannels have rarely been created in commercial hydrogel contact lenses due to their sensitivity to conventional microfabrication techniques. Here, we report the fabrication of microchannels in poly(2-hydroxyethyl methacrylate) (poly(HEMA)) hydrogels that are used in commercial contact lenses with a three-dimensional (3D) printed mold. We investigated the corresponding capillary flow behaviors in these microchannels. We observed different capillary flow regimes in these microchannels, depending on their hydration level. In particular, we found that a peristaltic pressure could reinstate flow in a dehydrated channel, indicating that the motion of eye-blinking may help tears flow in a microchannel-containing contact lens. Colorimetric pH and electrochemical Na+ sensing capabilities were demonstrated in these microchannels. This work paves the way for the development of microengineered poly(HEMA) hydrogels for various biomedical applications such as eye-care and wearable biosensing.
Persistent Identifierhttp://hdl.handle.net/10722/295437
ISSN
2023 Impact Factor: 6.1
2023 SCImago Journal Rankings: 1.246
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChen, Yihang-
dc.contributor.authorZhang, Shiming-
dc.contributor.authorCui, Qingyu-
dc.contributor.authorNi, Jiahua-
dc.contributor.authorWang, Xiaochen-
dc.contributor.authorCheng, Xuanbing-
dc.contributor.authorAlem, Halima-
dc.contributor.authorTebon, Peyton-
dc.contributor.authorXu, Chun-
dc.contributor.authorGuo, Changliang-
dc.contributor.authorNasiri, Rohollah-
dc.contributor.authorMoreddu, Rosalia-
dc.contributor.authorYetisen, Ali K.-
dc.contributor.authorAhadian, Samad-
dc.contributor.authorAshammakhi, Nureddin-
dc.contributor.authorEmaminejad, Sam-
dc.contributor.authorJucaud, Vadim-
dc.contributor.authorDokmeci, Mehmet R.-
dc.contributor.authorKhademhosseini, Ali-
dc.date.accessioned2021-01-18T15:46:52Z-
dc.date.available2021-01-18T15:46:52Z-
dc.date.issued2020-
dc.identifier.citationLab on a Chip, 2020, v. 20, n. 22, p. 4205-4214-
dc.identifier.issn1473-0197-
dc.identifier.urihttp://hdl.handle.net/10722/295437-
dc.description.abstract© 2020 The Royal Society of Chemistry. Microchannels in hydrogels play an essential role in enabling a smart contact lens. However, microchannels have rarely been created in commercial hydrogel contact lenses due to their sensitivity to conventional microfabrication techniques. Here, we report the fabrication of microchannels in poly(2-hydroxyethyl methacrylate) (poly(HEMA)) hydrogels that are used in commercial contact lenses with a three-dimensional (3D) printed mold. We investigated the corresponding capillary flow behaviors in these microchannels. We observed different capillary flow regimes in these microchannels, depending on their hydration level. In particular, we found that a peristaltic pressure could reinstate flow in a dehydrated channel, indicating that the motion of eye-blinking may help tears flow in a microchannel-containing contact lens. Colorimetric pH and electrochemical Na+ sensing capabilities were demonstrated in these microchannels. This work paves the way for the development of microengineered poly(HEMA) hydrogels for various biomedical applications such as eye-care and wearable biosensing.-
dc.languageeng-
dc.relation.ispartofLab on a Chip-
dc.titleMicroengineered poly(HEMA) hydrogels for wearable contact lens biosensing-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1039/d0lc00446d-
dc.identifier.pmid33048069-
dc.identifier.scopuseid_2-s2.0-85096039258-
dc.identifier.volume20-
dc.identifier.issue22-
dc.identifier.spage4205-
dc.identifier.epage4214-
dc.identifier.eissn1473-0189-
dc.identifier.isiWOS:000588192800007-
dc.identifier.issnl1473-0189-

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