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- Publisher Website: 10.1021/acs.jafc.0c06690
- Scopus: eid_2-s2.0-85099100351
- PMID: 33351614
- WOS: WOS:000687186300018
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Article: Walnut-Enriched Diet Elevated α-Linolenic Acid, Phytoprostanes, and Phytofurans in Rat Liver and Heart Tissues and Modulated Anti-inflammatory Lipid Mediators in the Liver
Title | Walnut-Enriched Diet Elevated α-Linolenic Acid, Phytoprostanes, and Phytofurans in Rat Liver and Heart Tissues and Modulated Anti-inflammatory Lipid Mediators in the Liver |
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Authors | |
Keywords | walnut α-linolenic acid phytoprostanes phytofurans neuroprostanes |
Issue Date | 2020 |
Publisher | American Chemical Society. The Journal's web site is located at http://pubs.acs.org/journal/jafcau |
Citation | Journal of Agricultural and Food Chemistry, 2020, Epub 2020-12-22 How to Cite? |
Abstract | α-Linolenic acid (ALA) and its non-enzymatic oxidized products, namely, phytoprostanes and phytofurans, are found in some nuts. The uptake and deposition of these compounds are not well-defined. Walnut has high ALA and a considerable amount of phytoprostanes and phytofurans compared to other common nuts. When fed to rodents, ALA and eicosapentaenoic acid levels increased in the liver and heart tissues compared to the control diet. Furthermore, phytoprostanes and phytofurans were elevated 3-fold in both tissues after a walnut diet, indicating that they are not only contributed from the diet but also generated through in vivo autoxidation of ALA found in the walnuts. It was further noted that a walnut diet reduced 5-F2t-isoprostanes and 12-hydroxyeicosatetraenoic acid and induced 4-F4t-neuroprostane and significant amounts of anti-inflammatory hydroxydocosahexaenoic acid in the liver only. Altogether, high ALA in a walnut diet elevated phytoprostanes and phytofurans in the liver and heart tissues and showed the regulation of anti-inflammatory lipid mediators in the liver only. |
Persistent Identifier | http://hdl.handle.net/10722/295360 |
ISSN | 2023 Impact Factor: 5.7 2023 SCImago Journal Rankings: 1.114 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | LEUNG, KS | - |
dc.contributor.author | Galano, JM | - |
dc.contributor.author | YAU, YF | - |
dc.contributor.author | Oger, C | - |
dc.contributor.author | Durand, T | - |
dc.contributor.author | Lee, JCY | - |
dc.date.accessioned | 2021-01-11T13:59:00Z | - |
dc.date.available | 2021-01-11T13:59:00Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Journal of Agricultural and Food Chemistry, 2020, Epub 2020-12-22 | - |
dc.identifier.issn | 0021-8561 | - |
dc.identifier.uri | http://hdl.handle.net/10722/295360 | - |
dc.description.abstract | α-Linolenic acid (ALA) and its non-enzymatic oxidized products, namely, phytoprostanes and phytofurans, are found in some nuts. The uptake and deposition of these compounds are not well-defined. Walnut has high ALA and a considerable amount of phytoprostanes and phytofurans compared to other common nuts. When fed to rodents, ALA and eicosapentaenoic acid levels increased in the liver and heart tissues compared to the control diet. Furthermore, phytoprostanes and phytofurans were elevated 3-fold in both tissues after a walnut diet, indicating that they are not only contributed from the diet but also generated through in vivo autoxidation of ALA found in the walnuts. It was further noted that a walnut diet reduced 5-F2t-isoprostanes and 12-hydroxyeicosatetraenoic acid and induced 4-F4t-neuroprostane and significant amounts of anti-inflammatory hydroxydocosahexaenoic acid in the liver only. Altogether, high ALA in a walnut diet elevated phytoprostanes and phytofurans in the liver and heart tissues and showed the regulation of anti-inflammatory lipid mediators in the liver only. | - |
dc.language | eng | - |
dc.publisher | American Chemical Society. The Journal's web site is located at http://pubs.acs.org/journal/jafcau | - |
dc.relation.ispartof | Journal of Agricultural and Food Chemistry | - |
dc.rights | This document is the Accepted Manuscript version of a Published Work that appeared in final form in [JournalTitle], copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see [insert ACS Articles on Request author-directed link to Published Work, see http://pubs.acs.org/page/policy/articlesonrequest/index.html]. | - |
dc.subject | walnut | - |
dc.subject | α-linolenic acid | - |
dc.subject | phytoprostanes | - |
dc.subject | phytofurans | - |
dc.subject | neuroprostanes | - |
dc.title | Walnut-Enriched Diet Elevated α-Linolenic Acid, Phytoprostanes, and Phytofurans in Rat Liver and Heart Tissues and Modulated Anti-inflammatory Lipid Mediators in the Liver | - |
dc.type | Article | - |
dc.identifier.email | Lee, JCY: jettylee@hku.hk | - |
dc.identifier.authority | Lee, JCY=rp01511 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1021/acs.jafc.0c06690 | - |
dc.identifier.pmid | 33351614 | - |
dc.identifier.scopus | eid_2-s2.0-85099100351 | - |
dc.identifier.hkuros | 320766 | - |
dc.identifier.volume | Epub 2020-12-22 | - |
dc.identifier.isi | WOS:000687186300018 | - |
dc.publisher.place | United States | - |