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Article: Development and functionalization of DNA nanostructures for biomedical applications
Title | Development and functionalization of DNA nanostructures for biomedical applications |
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Authors | |
Keywords | biological material biomedicine diagnostics DNA nanostructures drug delivery |
Issue Date | 2021 |
Publisher | Wiley-VCH Verlag for Chinese Chemical Society. The Journal's web site is located at http://www.wiley-vch.de/en/shop/journals/208 |
Citation | Journal of the Chinese Chemical Society, 2021, v. 68 n. 2, p. 228-238 How to Cite? |
Abstract | Nanomaterials are excellent drug delivery systems, yet, they must be functionalized in a manner compatible with the biological environment. Regarding delivery of the payloads, it is critical to monitor the nanocarrier's biocompatibility and the ability to control its drug encapsulation and release, as well as targeting. The current challenges include avoiding negative host immune responses, optimizing stability in biological environments, and achieving precise interactions with the targets. Contemporary advances in structural DNA nanotechnology, DNA origami, and supramolecular DNA assembly make it possible to produce complex multi-functional DNA nanostructures, wherein precise control of the size, geometry, and appearance of the ligands is feasible. DNA nanostructures offer ease of synthesis and conjugation of functional moieties to target the release of cargo or to analyze important biomarkers for diagnostics. Furthermore, the biocompatibility, programmability, responsiveness to biomolecules, cell-surfaces, and organisms make such DNA nanomaterials highly suitable for potential translational applications. This overview summarizes the recent developments in functionalizing, stabilizing, and applying DNA nanostructures for potential biomedical applications. |
Persistent Identifier | http://hdl.handle.net/10722/295246 |
ISSN | 2023 Impact Factor: 1.6 2023 SCImago Journal Rankings: 0.342 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Baig, MMFA | - |
dc.contributor.author | Zou, T | - |
dc.contributor.author | Neelakantan, P | - |
dc.contributor.author | Zhang, C | - |
dc.date.accessioned | 2021-01-11T13:57:24Z | - |
dc.date.available | 2021-01-11T13:57:24Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Journal of the Chinese Chemical Society, 2021, v. 68 n. 2, p. 228-238 | - |
dc.identifier.issn | 0009-4536 | - |
dc.identifier.uri | http://hdl.handle.net/10722/295246 | - |
dc.description.abstract | Nanomaterials are excellent drug delivery systems, yet, they must be functionalized in a manner compatible with the biological environment. Regarding delivery of the payloads, it is critical to monitor the nanocarrier's biocompatibility and the ability to control its drug encapsulation and release, as well as targeting. The current challenges include avoiding negative host immune responses, optimizing stability in biological environments, and achieving precise interactions with the targets. Contemporary advances in structural DNA nanotechnology, DNA origami, and supramolecular DNA assembly make it possible to produce complex multi-functional DNA nanostructures, wherein precise control of the size, geometry, and appearance of the ligands is feasible. DNA nanostructures offer ease of synthesis and conjugation of functional moieties to target the release of cargo or to analyze important biomarkers for diagnostics. Furthermore, the biocompatibility, programmability, responsiveness to biomolecules, cell-surfaces, and organisms make such DNA nanomaterials highly suitable for potential translational applications. This overview summarizes the recent developments in functionalizing, stabilizing, and applying DNA nanostructures for potential biomedical applications. | - |
dc.language | eng | - |
dc.publisher | Wiley-VCH Verlag for Chinese Chemical Society. The Journal's web site is located at http://www.wiley-vch.de/en/shop/journals/208 | - |
dc.relation.ispartof | Journal of the Chinese Chemical Society | - |
dc.rights | Preprint This is the pre-peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. Postprint This is the peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. | - |
dc.subject | biological material | - |
dc.subject | biomedicine | - |
dc.subject | diagnostics | - |
dc.subject | DNA nanostructures | - |
dc.subject | drug delivery | - |
dc.title | Development and functionalization of DNA nanostructures for biomedical applications | - |
dc.type | Article | - |
dc.identifier.email | Baig, MMFA: faran@HKUCC-COM.hku.hk | - |
dc.identifier.email | Zou, T: zouting6@hku.hk | - |
dc.identifier.email | Neelakantan, P: prasanna@hku.hk | - |
dc.identifier.email | Zhang, C: zhangcf@hku.hk | - |
dc.identifier.authority | Baig, MMFA=rp02755 | - |
dc.identifier.authority | Neelakantan, P=rp02214 | - |
dc.identifier.authority | Zhang, C=rp01408 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1002/jccs.202000373 | - |
dc.identifier.scopus | eid_2-s2.0-85100161442 | - |
dc.identifier.hkuros | 320889 | - |
dc.identifier.volume | 68 | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | 228 | - |
dc.identifier.epage | 238 | - |
dc.identifier.isi | WOS:000609927000001 | - |
dc.publisher.place | Taiwan | - |