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Article: Dietary phytochemical approaches to stem cell regulation

TitleDietary phytochemical approaches to stem cell regulation
Authors
KeywordsDifferentiation
Phytochemical
Regenerative medicine
Self-renewal
Stem cell
Issue Date2020
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/717426/description#description
Citation
Journal of Functional Foods, 2020, v. 66, p. article no. 103822 How to Cite?
AbstractControlling self-renewal and lineage differentiation of stem cells (SCs) is critical for SC therapy in regenerative medicine. Multiple signal pathways such as Wnt, TGF-β and BMP are involved in modulating proliferation or specific differentiation of different types of SCs. Dietary phytochemicals, the major source of new drugs, are found to stimulate self-renewal and sub-population differentiation of SCs by activating/inhibiting the signal pathways (MAPK, canonical Wnt/β-catenin, AKT, etc.) and key transcription factors (OCT4, NANOG, Runx2, etc.). Dietary phytochemicals are important for SC therapy owing to the plethora of targets. In this review, we discussed the SC types and their regulatory mechanism. Applications of phenols, flavonoids, sterols and alkaloids chemicals from food or herbs on targeting SCs along with their molecular mechanisms are also discussed. Dietary phytochemicals are promising to enhance endogenous/exogenous SC therapy in various diseases.
DescriptionHybrid open access
Persistent Identifierhttp://hdl.handle.net/10722/294858
ISSN
2023 Impact Factor: 3.8
2023 SCImago Journal Rankings: 0.900
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZhang, S-
dc.contributor.authorLAM, KKH-
dc.contributor.authorWAN, JH-
dc.contributor.authorYip, CW-
dc.contributor.authorLiu, HKH-
dc.contributor.authorLau, QMN-
dc.contributor.authorMan, AHY-
dc.contributor.authorCheung, CH-
dc.contributor.authorWong, LH-
dc.contributor.authorChen, HB-
dc.contributor.authorShi, J-
dc.contributor.authorLeung, GPH-
dc.contributor.authorLee, CKF-
dc.contributor.authorShi, YG-
dc.contributor.authorTang, SCW-
dc.contributor.authorZhang, KYB-
dc.date.accessioned2020-12-21T11:49:33Z-
dc.date.available2020-12-21T11:49:33Z-
dc.date.issued2020-
dc.identifier.citationJournal of Functional Foods, 2020, v. 66, p. article no. 103822-
dc.identifier.issn1756-4646-
dc.identifier.urihttp://hdl.handle.net/10722/294858-
dc.descriptionHybrid open access-
dc.description.abstractControlling self-renewal and lineage differentiation of stem cells (SCs) is critical for SC therapy in regenerative medicine. Multiple signal pathways such as Wnt, TGF-β and BMP are involved in modulating proliferation or specific differentiation of different types of SCs. Dietary phytochemicals, the major source of new drugs, are found to stimulate self-renewal and sub-population differentiation of SCs by activating/inhibiting the signal pathways (MAPK, canonical Wnt/β-catenin, AKT, etc.) and key transcription factors (OCT4, NANOG, Runx2, etc.). Dietary phytochemicals are important for SC therapy owing to the plethora of targets. In this review, we discussed the SC types and their regulatory mechanism. Applications of phenols, flavonoids, sterols and alkaloids chemicals from food or herbs on targeting SCs along with their molecular mechanisms are also discussed. Dietary phytochemicals are promising to enhance endogenous/exogenous SC therapy in various diseases.-
dc.languageeng-
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/717426/description#description-
dc.relation.ispartofJournal of Functional Foods-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectDifferentiation-
dc.subjectPhytochemical-
dc.subjectRegenerative medicine-
dc.subjectSelf-renewal-
dc.subjectStem cell-
dc.titleDietary phytochemical approaches to stem cell regulation-
dc.typeArticle-
dc.identifier.emailMan, AHY: alicemhy@hku.hk-
dc.identifier.emailShi, J: junshi@hku.hk-
dc.identifier.emailLeung, GPH: gphleung@hkucc.hku.hk-
dc.identifier.emailLee, CKF: ckflee@hku.hk-
dc.identifier.emailShi, YG: shiyig@hkucc.hku.hk-
dc.identifier.emailTang, SCW: scwtang@hku.hk-
dc.identifier.authorityLeung, GPH=rp00234-
dc.identifier.authorityLee, CKF=rp00458-
dc.identifier.authorityTang, SCW=rp00480-
dc.identifier.authorityZhang, KYB=rp01410-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1016/j.jff.2020.103822-
dc.identifier.scopuseid_2-s2.0-85079534037-
dc.identifier.hkuros320688-
dc.identifier.volume66-
dc.identifier.spagearticle no. 103822-
dc.identifier.epagearticle no. 103822-
dc.identifier.isiWOS:000518708200002-
dc.publisher.placeNetherlands-

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