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Article: Effects of mechanical forces on osteogenesis and osteoclastogenesis in human periodontal ligament fibroblasts: A systematic review of in vitro studies
Title | Effects of mechanical forces on osteogenesis and osteoclastogenesis in human periodontal ligament fibroblasts: A systematic review of in vitro studies |
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Authors | |
Keywords | Mechanical forces Osteoclastogenesis Osteogenesis Periodontal ligament fibroblasts |
Issue Date | 2019 |
Publisher | British Editorial Society of Bone and Joint Surgery: Open Access. The Journal's web site is located at http://www.bjr.boneandjoint.org.uk/ |
Citation | Bone & Joint Research, 2019, v. 8 n. 1, p. 19-31 How to Cite? |
Abstract | Objectives: Many in vitro studies have investigated the mechanism by which mechanical signals are transduced into biological signals that regulate bone homeostasis via periodontal ligament fibroblasts during orthodontic treatment, but the results have not been systematically reviewed. This review aims to do this, considering the parameters of various in vitro mechanical loading approaches and their effects on osteogenic and osteoclastogenic properties of periodontal ligament fibroblasts.
Methods: Specific keywords were used to search electronic databases (EMBASE, PubMed, and Web of Science) for English-language literature published between 1995 and 2017.
Results: A total of 26 studies from the 555 articles obtained via the database search were ultimately included, and four main types of biomechanical approach were identified. Compressive force is characterized by static and continuous application, whereas tensile force is mainly cyclic. Only nine studies investigated the mechanisms by which periodontal ligament fibroblasts transduce mechanical stimulus. The studies provided evidence from in vitro mechanical loading regimens that periodontal ligament fibroblasts play a unique and dominant role in the regulation of bone remodelling during orthodontic tooth movement.
Conclusion: Evidence from the reviewed studies described the characteristics of periodontal ligament fibroblasts exposed to mechanical force. This is expected to benefit subsequent research into periodontal ligament fibroblasts and to provide indirectly evidence-based insights regarding orthodontic treatment. Further studies should be performed to explore the effects of static tension on cytomechanical properties, better techniques for static compressive force loading, and deeper analysis of underlying regulatory systems.Cite this article: M. Li, C. Zhang, Y. Yang. Effects of mechanical forces on osteogenesis and osteoclastogenesis in human periodontal ligament fibroblasts: A systematic review of in vitro studies. Bone Joint Res 2019;8:19-31. DOI: 10.1302/2046-3758.81.BJR-2018-0060.R1. |
Persistent Identifier | http://hdl.handle.net/10722/294849 |
ISSN | 2023 Impact Factor: 4.7 2023 SCImago Journal Rankings: 1.372 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Li, M | - |
dc.contributor.author | Zhang, C | - |
dc.contributor.author | Yang, Y | - |
dc.date.accessioned | 2020-12-21T11:49:26Z | - |
dc.date.available | 2020-12-21T11:49:26Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Bone & Joint Research, 2019, v. 8 n. 1, p. 19-31 | - |
dc.identifier.issn | 2046-3758 | - |
dc.identifier.uri | http://hdl.handle.net/10722/294849 | - |
dc.description.abstract | Objectives: Many in vitro studies have investigated the mechanism by which mechanical signals are transduced into biological signals that regulate bone homeostasis via periodontal ligament fibroblasts during orthodontic treatment, but the results have not been systematically reviewed. This review aims to do this, considering the parameters of various in vitro mechanical loading approaches and their effects on osteogenic and osteoclastogenic properties of periodontal ligament fibroblasts. Methods: Specific keywords were used to search electronic databases (EMBASE, PubMed, and Web of Science) for English-language literature published between 1995 and 2017. Results: A total of 26 studies from the 555 articles obtained via the database search were ultimately included, and four main types of biomechanical approach were identified. Compressive force is characterized by static and continuous application, whereas tensile force is mainly cyclic. Only nine studies investigated the mechanisms by which periodontal ligament fibroblasts transduce mechanical stimulus. The studies provided evidence from in vitro mechanical loading regimens that periodontal ligament fibroblasts play a unique and dominant role in the regulation of bone remodelling during orthodontic tooth movement. Conclusion: Evidence from the reviewed studies described the characteristics of periodontal ligament fibroblasts exposed to mechanical force. This is expected to benefit subsequent research into periodontal ligament fibroblasts and to provide indirectly evidence-based insights regarding orthodontic treatment. Further studies should be performed to explore the effects of static tension on cytomechanical properties, better techniques for static compressive force loading, and deeper analysis of underlying regulatory systems.Cite this article: M. Li, C. Zhang, Y. Yang. Effects of mechanical forces on osteogenesis and osteoclastogenesis in human periodontal ligament fibroblasts: A systematic review of in vitro studies. Bone Joint Res 2019;8:19-31. DOI: 10.1302/2046-3758.81.BJR-2018-0060.R1. | - |
dc.language | eng | - |
dc.publisher | British Editorial Society of Bone and Joint Surgery: Open Access. The Journal's web site is located at http://www.bjr.boneandjoint.org.uk/ | - |
dc.relation.ispartof | Bone & Joint Research | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Mechanical forces | - |
dc.subject | Osteoclastogenesis | - |
dc.subject | Osteogenesis | - |
dc.subject | Periodontal ligament fibroblasts | - |
dc.title | Effects of mechanical forces on osteogenesis and osteoclastogenesis in human periodontal ligament fibroblasts: A systematic review of in vitro studies | - |
dc.type | Article | - |
dc.identifier.email | Zhang, C: zhangcf@hku.hk | - |
dc.identifier.email | Yang, Y: yangyanq@hku.hk | - |
dc.identifier.authority | Zhang, C=rp01408 | - |
dc.identifier.authority | Yang, Y=rp00045 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1302/2046-3758.81.BJR-2018-0060.R1 | - |
dc.identifier.pmid | 30800296 | - |
dc.identifier.pmcid | PMC6359886 | - |
dc.identifier.scopus | eid_2-s2.0-85100468194 | - |
dc.identifier.hkuros | 320731 | - |
dc.identifier.volume | 8 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 19 | - |
dc.identifier.epage | 31 | - |
dc.identifier.isi | WOS:000458212800004 | - |
dc.publisher.place | United Kingdom | - |