File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1681/ASN.2020050659
- Scopus: eid_2-s2.0-85102133273
- PMID: 33318152
- WOS: WOS:000627410900017
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Sex-specific associations of sex hormone binding globulin with CKD and kidney function: a univariable and multivariable Mendelian randomization study in the UK Biobank
Title | Sex-specific associations of sex hormone binding globulin with CKD and kidney function: a univariable and multivariable Mendelian randomization study in the UK Biobank |
---|---|
Authors | |
Keywords | chronic kidney disease risk factors gender difference sex hormone binding globulin |
Issue Date | 2021 |
Publisher | American Society of Nephrology. The Journal's web site is located at http://www.jasn.org |
Citation | Journal of the American Society of Nephrology, 2021, v. 32 n. 3, p. 686-694 How to Cite? |
Abstract | Background: Kidney function declines faster in men. Testosterone levels may mediate the sex disparity. Correspondingly, levels of sex hormone binding globulin (SHBG), which modulates sex hormones, might also be relevant to the lower kidney function in men. The sex-specific role of SHBG is unclear.
Methods: A sex-specific, Mendelian randomization (MR) study provided unconfounded estimates of SHBG levels among the United Kingdom Biobank population. Univariable MR applied 357 single nucleotide polymorphisms (SNPs) in men and 359 SNPs in women. These published SNPs strongly (P<5×10−8) predict SHBG level. They were profiled in 179,916 white British men (6016 patients with CKD) and 212,079 white British women (5958 patients with CKD), to obtain the effect of SHBG on CKD, albuminuria, and eGFR. Multivariable MR controlling for testosterone was used to assess the effect of SHBG on CKD and kidney function independent of testosterone in men.
Results: Genetically predicted higher SHBG was associated with a lower risk of CKD in men (odds ratio [OR], 0.78 per SD; 95% confidence interval [95% CI], 0.65 to 0.93) but had no benefit in women. The effect in men remained in multivariable MR, allowing for testosterone (OR, 0.61; 95% CI, 0.45 to 0.82).
Conclusions: Genetically predicted higher SHBG was associated with a lower risk of CKD and better kidney function in men, but not in women, suggesting that SHBG may play a role in CKD specifically in men. Identifying drivers of SHBG and the underlying pathways could provide new insights into CKD prevention and treatment. |
Persistent Identifier | http://hdl.handle.net/10722/294555 |
ISSN | 2023 Impact Factor: 10.3 2023 SCImago Journal Rankings: 3.409 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Zhao, JV | - |
dc.contributor.author | Schooling, CM | - |
dc.date.accessioned | 2020-12-08T07:38:39Z | - |
dc.date.available | 2020-12-08T07:38:39Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Journal of the American Society of Nephrology, 2021, v. 32 n. 3, p. 686-694 | - |
dc.identifier.issn | 1046-6673 | - |
dc.identifier.uri | http://hdl.handle.net/10722/294555 | - |
dc.description.abstract | Background: Kidney function declines faster in men. Testosterone levels may mediate the sex disparity. Correspondingly, levels of sex hormone binding globulin (SHBG), which modulates sex hormones, might also be relevant to the lower kidney function in men. The sex-specific role of SHBG is unclear. Methods: A sex-specific, Mendelian randomization (MR) study provided unconfounded estimates of SHBG levels among the United Kingdom Biobank population. Univariable MR applied 357 single nucleotide polymorphisms (SNPs) in men and 359 SNPs in women. These published SNPs strongly (P<5×10−8) predict SHBG level. They were profiled in 179,916 white British men (6016 patients with CKD) and 212,079 white British women (5958 patients with CKD), to obtain the effect of SHBG on CKD, albuminuria, and eGFR. Multivariable MR controlling for testosterone was used to assess the effect of SHBG on CKD and kidney function independent of testosterone in men. Results: Genetically predicted higher SHBG was associated with a lower risk of CKD in men (odds ratio [OR], 0.78 per SD; 95% confidence interval [95% CI], 0.65 to 0.93) but had no benefit in women. The effect in men remained in multivariable MR, allowing for testosterone (OR, 0.61; 95% CI, 0.45 to 0.82). Conclusions: Genetically predicted higher SHBG was associated with a lower risk of CKD and better kidney function in men, but not in women, suggesting that SHBG may play a role in CKD specifically in men. Identifying drivers of SHBG and the underlying pathways could provide new insights into CKD prevention and treatment. | - |
dc.language | eng | - |
dc.publisher | American Society of Nephrology. The Journal's web site is located at http://www.jasn.org | - |
dc.relation.ispartof | Journal of the American Society of Nephrology | - |
dc.subject | chronic kidney disease | - |
dc.subject | risk factors | - |
dc.subject | gender difference | - |
dc.subject | sex hormone binding globulin | - |
dc.title | Sex-specific associations of sex hormone binding globulin with CKD and kidney function: a univariable and multivariable Mendelian randomization study in the UK Biobank | - |
dc.type | Article | - |
dc.identifier.email | Zhao, JV: janezhao@hku.hk | - |
dc.identifier.email | Schooling, CM: cms1@hkucc.hku.hk | - |
dc.identifier.authority | Zhao, JV=rp02336 | - |
dc.identifier.authority | Schooling, CM=rp00504 | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1681/ASN.2020050659 | - |
dc.identifier.pmid | 33318152 | - |
dc.identifier.pmcid | PMC7920164 | - |
dc.identifier.scopus | eid_2-s2.0-85102133273 | - |
dc.identifier.hkuros | 320494 | - |
dc.identifier.volume | 32 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 686 | - |
dc.identifier.epage | 694 | - |
dc.identifier.isi | WOS:000627410900017 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 1046-6673 | - |