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Article: Transplant Outcomes for Children with T Cell Acute Lymphoblastic Leukemia in Second Remission: A Report from the Center for International Blood and Marrow Transplant Research

TitleTransplant Outcomes for Children with T Cell Acute Lymphoblastic Leukemia in Second Remission: A Report from the Center for International Blood and Marrow Transplant Research
Authors
KeywordsTransplantation
Relapse
T-cell ALL
Acute lymphoblastic leukemia
Pediatric
Issue Date2015
Citation
Biology of Blood and Marrow Transplantation, 2015, v. 21, n. 12, p. 2154-2159 How to Cite?
Abstract© 2015 American Society for Blood and Marrow Transplantation. Survival for children with relapsed T cell acute lymphoblastic leukemia (T-ALL) is poor when treated with chemotherapy alone, and outcomes after allogeneic hematopoietic cell transplantation (HCT) is not well described. Two hundred twenty-nine children with T-ALL in second complete remission (CR2) received an HCT after myeloablative conditioning between 2000 and 2011 and were reported to the Center for International Blood and Marrow Transplant Research. Median age was 10 years (range, 2 to 18). Donor source was umbilical cord blood (26%), matched sibling bone marrow (38%), or unrelated bone marrow/peripheral blood (36%). Acute (grades II to IV) and chronic graft-versus-host disease occurred in, respectively, 35% (95% confidence interval [CI], 27% to 45%) and 26% (95% CI, 20% to 33%) of patients. Transplant-related mortality at day 100 and 3-year relapse rates were 13% (95% CI, 9% to 18%) and 30% (95% CI, 24% to 37%), respectively. Three-year overall survival and disease-free survival rates were 48% (95% CI, 41% to 55%) and 46% (95% CI, 39% to 52%), respectively. In multivariate analysis, patients with bone marrow relapse, with or without concurrent extramedullary relapse before HCT, were most likely to relapse (hazard ratio, 3.94; P = .005) as compared with isolated extramedullary disease. In conclusion, HCT for pediatric T-ALL in CR2 demonstrates reasonable and durable outcomes, and consideration for HCT is warranted.
Persistent Identifierhttp://hdl.handle.net/10722/294508
ISSN
2022 Impact Factor: 4.3
2020 SCImago Journal Rankings: 2.301
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorBurke, Michael J.-
dc.contributor.authorVerneris, Michael R.-
dc.contributor.authorLe Rademacher, Jennifer-
dc.contributor.authorHe, Wensheng-
dc.contributor.authorAbdel-Azim, Hisham-
dc.contributor.authorAbraham, Allistair A.-
dc.contributor.authorAuletta, Jeffery J.-
dc.contributor.authorAyas, Mouhab-
dc.contributor.authorBrown, Valerie I.-
dc.contributor.authorCairo, Mitchell S.-
dc.contributor.authorChan, Ka Wah-
dc.contributor.authorDiaz Perez, Miguel A.-
dc.contributor.authorDvorak, Christopher C.-
dc.contributor.authorEgeler, R. Maarten-
dc.contributor.authorEldjerou, Lamis-
dc.contributor.authorFrangoul, Haydar-
dc.contributor.authorGuilcher, Gregory M.T.-
dc.contributor.authorHayashi, Robert J.-
dc.contributor.authorIbrahim, Ahmed-
dc.contributor.authorKasow, Kimberly A.-
dc.contributor.authorLeung, Wing H.-
dc.contributor.authorOlsson, Richard F.-
dc.contributor.authorPulsipher, Michael A.-
dc.contributor.authorShah, Niketa-
dc.contributor.authorShah, Nirali N.-
dc.contributor.authorThiel, Elizabeth-
dc.contributor.authorTalano, Julie An-
dc.contributor.authorKitko, Carrie L.-
dc.date.accessioned2020-12-03T08:22:53Z-
dc.date.available2020-12-03T08:22:53Z-
dc.date.issued2015-
dc.identifier.citationBiology of Blood and Marrow Transplantation, 2015, v. 21, n. 12, p. 2154-2159-
dc.identifier.issn1083-8791-
dc.identifier.urihttp://hdl.handle.net/10722/294508-
dc.description.abstract© 2015 American Society for Blood and Marrow Transplantation. Survival for children with relapsed T cell acute lymphoblastic leukemia (T-ALL) is poor when treated with chemotherapy alone, and outcomes after allogeneic hematopoietic cell transplantation (HCT) is not well described. Two hundred twenty-nine children with T-ALL in second complete remission (CR2) received an HCT after myeloablative conditioning between 2000 and 2011 and were reported to the Center for International Blood and Marrow Transplant Research. Median age was 10 years (range, 2 to 18). Donor source was umbilical cord blood (26%), matched sibling bone marrow (38%), or unrelated bone marrow/peripheral blood (36%). Acute (grades II to IV) and chronic graft-versus-host disease occurred in, respectively, 35% (95% confidence interval [CI], 27% to 45%) and 26% (95% CI, 20% to 33%) of patients. Transplant-related mortality at day 100 and 3-year relapse rates were 13% (95% CI, 9% to 18%) and 30% (95% CI, 24% to 37%), respectively. Three-year overall survival and disease-free survival rates were 48% (95% CI, 41% to 55%) and 46% (95% CI, 39% to 52%), respectively. In multivariate analysis, patients with bone marrow relapse, with or without concurrent extramedullary relapse before HCT, were most likely to relapse (hazard ratio, 3.94; P = .005) as compared with isolated extramedullary disease. In conclusion, HCT for pediatric T-ALL in CR2 demonstrates reasonable and durable outcomes, and consideration for HCT is warranted.-
dc.languageeng-
dc.relation.ispartofBiology of Blood and Marrow Transplantation-
dc.subjectTransplantation-
dc.subjectRelapse-
dc.subjectT-cell ALL-
dc.subjectAcute lymphoblastic leukemia-
dc.subjectPediatric-
dc.titleTransplant Outcomes for Children with T Cell Acute Lymphoblastic Leukemia in Second Remission: A Report from the Center for International Blood and Marrow Transplant Research-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1016/j.bbmt.2015.08.023-
dc.identifier.pmid26327632-
dc.identifier.pmcidPMC4654112-
dc.identifier.scopuseid_2-s2.0-84947443750-
dc.identifier.volume21-
dc.identifier.issue12-
dc.identifier.spage2154-
dc.identifier.epage2159-
dc.identifier.eissn1523-6536-
dc.identifier.isiWOS:000364981700018-
dc.identifier.issnl1083-8791-

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