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- Publisher Website: 10.1111/bjh.13107
- Scopus: eid_2-s2.0-84915737335
- PMID: 25164427
- WOS: WOS:000346151600012
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Article: Prognostic factors in children with acute myeloid leukaemia and excellent response to remission induction therapy
Title | Prognostic factors in children with acute myeloid leukaemia and excellent response to remission induction therapy |
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Authors | |
Keywords | Paediatric Acute myeloid leukaemia Minimal residual disease Prognostic factor |
Issue Date | 2015 |
Citation | British Journal of Haematology, 2015, v. 168, n. 1, p. 94-101 How to Cite? |
Abstract | © 2014 John Wiley & Sons Ltd. Minimal residual disease (MRD) is a strong prognostic factor in children and adolescents with acute myeloid leukaemia (AML) but nearly one-quarter of patients who achieve MRD-negative status still relapse. The adverse prognostic factors among MRD-negative patients remain unknown. We analysed the AML02 study cohort to identify demographic and genetic prognostic factors. Among the presenting features, certain 11q23 abnormalities, such as t(6;11) and t(10;11), acute megakaryoblastic leukaemia without the t(1;22), and age ≥10 years were associated with inferior outcome in patients who had MRD-negative status after either remission induction I or II. By contrast, those with rearrangement of CBF genes had superior outcome. Our study identifies patient populations for whom close post-remission MRD monitoring to detect and treat emerging relapse and adjustment in treatment intensity might be indicated. |
Persistent Identifier | http://hdl.handle.net/10722/294472 |
ISSN | 2021 Impact Factor: 8.615 2020 SCImago Journal Rankings: 1.907 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Karol, Seth E. | - |
dc.contributor.author | Coustan-Smith, Elaine | - |
dc.contributor.author | Cao, Xueyuan | - |
dc.contributor.author | Shurtleff, Sheila A. | - |
dc.contributor.author | Raimondi, Susana C. | - |
dc.contributor.author | Choi, John K. | - |
dc.contributor.author | Ribeiro, Raul C. | - |
dc.contributor.author | Dahl, Gary V. | - |
dc.contributor.author | Bowman, William Paul | - |
dc.contributor.author | Taub, Jeffrey W. | - |
dc.contributor.author | Degar, Barbara | - |
dc.contributor.author | Leung, Wing | - |
dc.contributor.author | Downing, James R. | - |
dc.contributor.author | Pui, Ching Hon | - |
dc.contributor.author | Rubnitz, Jeffrey E. | - |
dc.contributor.author | Campana, Dario | - |
dc.contributor.author | Inaba, Hiroto | - |
dc.date.accessioned | 2020-12-03T08:22:49Z | - |
dc.date.available | 2020-12-03T08:22:49Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | British Journal of Haematology, 2015, v. 168, n. 1, p. 94-101 | - |
dc.identifier.issn | 0007-1048 | - |
dc.identifier.uri | http://hdl.handle.net/10722/294472 | - |
dc.description.abstract | © 2014 John Wiley & Sons Ltd. Minimal residual disease (MRD) is a strong prognostic factor in children and adolescents with acute myeloid leukaemia (AML) but nearly one-quarter of patients who achieve MRD-negative status still relapse. The adverse prognostic factors among MRD-negative patients remain unknown. We analysed the AML02 study cohort to identify demographic and genetic prognostic factors. Among the presenting features, certain 11q23 abnormalities, such as t(6;11) and t(10;11), acute megakaryoblastic leukaemia without the t(1;22), and age ≥10 years were associated with inferior outcome in patients who had MRD-negative status after either remission induction I or II. By contrast, those with rearrangement of CBF genes had superior outcome. Our study identifies patient populations for whom close post-remission MRD monitoring to detect and treat emerging relapse and adjustment in treatment intensity might be indicated. | - |
dc.language | eng | - |
dc.relation.ispartof | British Journal of Haematology | - |
dc.subject | Paediatric | - |
dc.subject | Acute myeloid leukaemia | - |
dc.subject | Minimal residual disease | - |
dc.subject | Prognostic factor | - |
dc.title | Prognostic factors in children with acute myeloid leukaemia and excellent response to remission induction therapy | - |
dc.type | Article | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1111/bjh.13107 | - |
dc.identifier.pmid | 25164427 | - |
dc.identifier.pmcid | PMC4262553 | - |
dc.identifier.scopus | eid_2-s2.0-84915737335 | - |
dc.identifier.volume | 168 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 94 | - |
dc.identifier.epage | 101 | - |
dc.identifier.eissn | 1365-2141 | - |
dc.identifier.isi | WOS:000346151600012 | - |
dc.identifier.issnl | 0007-1048 | - |