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Article: Frequent mutations in SH2D1A (XLP) in males presenting with high-grade mature B-cell neoplasms

TitleFrequent mutations in SH2D1A (XLP) in males presenting with high-grade mature B-cell neoplasms
Authors
KeywordsLymphoma
XLP
EBV
B cells
Issue Date2013
Citation
Pediatric Blood and Cancer, 2013, v. 60, n. 9, p. E85-E87 How to Cite?
AbstractX-linked lymphoproliferative syndrome (XLP) is caused by mutations in SH2D1A, and is associated with overwhelming infectious mononucleosis, aplastic anemia, hypogammaglobulinemia, and B-cell lymphomas. However, the frequency of SH2D1A mutations in males who present with B NHL is unknown. Five cases of XLP were diagnosed among 158 males presenting with B NHL (approximately 3.2%). Four of the patients had two episodes of B NHL and one had a single episode of B NHL followed by aggressive infectious mononucleosis. Prospective screening for XLP in males with B-cell lymphoma at the time of initial diagnosis should be considered. © 2013 Wiley Periodicals, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/294466
ISSN
2023 Impact Factor: 2.4
2023 SCImago Journal Rankings: 0.992
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorSandlund, J. T.-
dc.contributor.authorShurtleff, S. A.-
dc.contributor.authorOnciu, M.-
dc.contributor.authorHorwitz, E.-
dc.contributor.authorLeung, W.-
dc.contributor.authorHoward, V.-
dc.contributor.authorRencher, R.-
dc.contributor.authorConley, M. E.-
dc.date.accessioned2020-12-03T08:22:48Z-
dc.date.available2020-12-03T08:22:48Z-
dc.date.issued2013-
dc.identifier.citationPediatric Blood and Cancer, 2013, v. 60, n. 9, p. E85-E87-
dc.identifier.issn1545-5009-
dc.identifier.urihttp://hdl.handle.net/10722/294466-
dc.description.abstractX-linked lymphoproliferative syndrome (XLP) is caused by mutations in SH2D1A, and is associated with overwhelming infectious mononucleosis, aplastic anemia, hypogammaglobulinemia, and B-cell lymphomas. However, the frequency of SH2D1A mutations in males who present with B NHL is unknown. Five cases of XLP were diagnosed among 158 males presenting with B NHL (approximately 3.2%). Four of the patients had two episodes of B NHL and one had a single episode of B NHL followed by aggressive infectious mononucleosis. Prospective screening for XLP in males with B-cell lymphoma at the time of initial diagnosis should be considered. © 2013 Wiley Periodicals, Inc.-
dc.languageeng-
dc.relation.ispartofPediatric Blood and Cancer-
dc.subjectLymphoma-
dc.subjectXLP-
dc.subjectEBV-
dc.subjectB cells-
dc.titleFrequent mutations in SH2D1A (XLP) in males presenting with high-grade mature B-cell neoplasms-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1002/pbc.24525-
dc.identifier.pmid23589280-
dc.identifier.pmcidPMC4758190-
dc.identifier.scopuseid_2-s2.0-84880326475-
dc.identifier.volume60-
dc.identifier.issue9-
dc.identifier.spageE85-
dc.identifier.epageE87-
dc.identifier.eissn1545-5017-
dc.identifier.isiWOS:000321703900057-
dc.identifier.issnl1545-5009-

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