File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Osteonecrosis in children after allogeneic hematopoietic cell transplantation: Study of prevalence, risk factors and longitudinal changes using MR imaging

TitleOsteonecrosis in children after allogeneic hematopoietic cell transplantation: Study of prevalence, risk factors and longitudinal changes using MR imaging
Authors
KeywordsGVHD
children
osteonecrosis
hematopoietic stem cell
Issue Date2012
Citation
Bone Marrow Transplantation, 2012, v. 47, n. 8, p. 1067-1074 How to Cite?
AbstractOsteonecrosis after hematopoietic SCT (HCT) has seldom been addressed in pediatric populations. At our institution, since January 2002, children undergoing allogeneic HCT (alloHCT) receive yearly follow-up magnetic resonance imaging (MR) of hips and knees. To estimate the prevalence, longitudinal changes and associated risk factors for osteonecrosis after alloHCT, we reviewed MRs for children who underwent single alloHCT during the study period. We analyzed 149 of 344 patients who had post-HCT MR imaging performed (84 males; median age 11 years (range, 0.5-21years)), median follow-up time was 32.6 months (range, 2.8-97.2 months). In all, 44 (29.5%) developed osteonecrosis of hips and/or knees; of those, 20 (45%) had at least 30% epiphyseal involvement. In 23 (52%), osteonecrosis lesions were identified in the first and in 43 (98%) by the third yearly scan. Knees were more frequently involved than hips; severity of osteonecrosis was greater in hips. Those who had pre-alloHCT osteonecrosis, two patients hips and six patients knees resolved completely; three patients osteonecrosis lesions regressed after alloHCT. On risk factor analysis, age at time of alloHCT (P0.051) and osteonecrosis identified by MRs before alloHCT (P0.001) were the primary risk factors. This analysis shows that preventive strategies for osteonecrosis in this population should focus on measures to minimize risk factors before alloHCT. © 2012 Macmillan Publishers Limited.
Persistent Identifierhttp://hdl.handle.net/10722/294455
ISSN
2023 Impact Factor: 4.5
2023 SCImago Journal Rankings: 1.318
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorSharma, S.-
dc.contributor.authorLeung, W. H.-
dc.contributor.authorDeqing, P.-
dc.contributor.authorYang, J.-
dc.contributor.authorRochester, R.-
dc.contributor.authorBritton, L.-
dc.contributor.authorNeel, M. D.-
dc.contributor.authorNess, K. K.-
dc.contributor.authorKaste, S. C.-
dc.date.accessioned2020-12-03T08:22:46Z-
dc.date.available2020-12-03T08:22:46Z-
dc.date.issued2012-
dc.identifier.citationBone Marrow Transplantation, 2012, v. 47, n. 8, p. 1067-1074-
dc.identifier.issn0268-3369-
dc.identifier.urihttp://hdl.handle.net/10722/294455-
dc.description.abstractOsteonecrosis after hematopoietic SCT (HCT) has seldom been addressed in pediatric populations. At our institution, since January 2002, children undergoing allogeneic HCT (alloHCT) receive yearly follow-up magnetic resonance imaging (MR) of hips and knees. To estimate the prevalence, longitudinal changes and associated risk factors for osteonecrosis after alloHCT, we reviewed MRs for children who underwent single alloHCT during the study period. We analyzed 149 of 344 patients who had post-HCT MR imaging performed (84 males; median age 11 years (range, 0.5-21years)), median follow-up time was 32.6 months (range, 2.8-97.2 months). In all, 44 (29.5%) developed osteonecrosis of hips and/or knees; of those, 20 (45%) had at least 30% epiphyseal involvement. In 23 (52%), osteonecrosis lesions were identified in the first and in 43 (98%) by the third yearly scan. Knees were more frequently involved than hips; severity of osteonecrosis was greater in hips. Those who had pre-alloHCT osteonecrosis, two patients hips and six patients knees resolved completely; three patients osteonecrosis lesions regressed after alloHCT. On risk factor analysis, age at time of alloHCT (P0.051) and osteonecrosis identified by MRs before alloHCT (P0.001) were the primary risk factors. This analysis shows that preventive strategies for osteonecrosis in this population should focus on measures to minimize risk factors before alloHCT. © 2012 Macmillan Publishers Limited.-
dc.languageeng-
dc.relation.ispartofBone Marrow Transplantation-
dc.subjectGVHD-
dc.subjectchildren-
dc.subjectosteonecrosis-
dc.subjecthematopoietic stem cell-
dc.titleOsteonecrosis in children after allogeneic hematopoietic cell transplantation: Study of prevalence, risk factors and longitudinal changes using MR imaging-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1038/bmt.2011.234-
dc.identifier.pmid22158389-
dc.identifier.pmcidPMC3310343-
dc.identifier.scopuseid_2-s2.0-84864881663-
dc.identifier.volume47-
dc.identifier.issue8-
dc.identifier.spage1067-
dc.identifier.epage1074-
dc.identifier.eissn1476-5365-
dc.identifier.isiWOS:000307648300008-
dc.identifier.issnl0268-3369-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats