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Article: Prevalence of osteonecrosis and associated risk factors in children before allogeneic BMT

TitlePrevalence of osteonecrosis and associated risk factors in children before allogeneic BMT
Authors
Keywordsallogeneic BMT
osteonecrosis
aplastic anemia
children
lymphphoid malignancies
Issue Date2011
Citation
Bone Marrow Transplantation, 2011, v. 46, n. 6, p. 813-819 How to Cite?
AbstractOsteonecrosis (ON) is a debilitating long-term complication of allogeneic BMT (allo-BMT), but may begin before allo-BMT in some children because of their primary disease treatment. Therefore, to estimate the prevalence and associated risk factors for ON before allo-BMT, we conducted a retrospective analysis of magnetic resonance (MR) studies of 118 children who underwent first allo-BMT at our institution between December 2000 and September 2007. Of the 118 consecutive patients, 107 (90.7%) underwent prospective MR studies irrespective of symptoms (69 males; median age at allo-BMT 12.9 years), and 11 underwent MR studies for symptoms. Among the 107 who had prospective imaging, 23 (21.5%) had ON; nearly 50% had at least 30% epiphyseal involvement. Knees were more frequently involved than were hips; severity of ON was greater in hips. ON prevalence before allo-BMT was 23.72% when all 118 patients were included in the denominator. Risk factor analysis, limited to MR studies performed irrespective of symptoms, revealed female gender (P=0.049) and age ≥10 years at the time of MR study (P=0.03) as significant risk factors, and primary diagnosis of lymphoid malignancies and aplastic anemia trended toward significance. ON before allo-BMT is a common occurrence in children. © 2011 Macmillan Publishers Limited All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/294441
ISSN
2023 Impact Factor: 4.5
2023 SCImago Journal Rankings: 1.318
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorSharma, S.-
dc.contributor.authorYang, S.-
dc.contributor.authorRochester, R.-
dc.contributor.authorBritton, L.-
dc.contributor.authorLeung, W. H.-
dc.contributor.authorYang, J.-
dc.contributor.authorNeel, M. D.-
dc.contributor.authorNess, K. K.-
dc.contributor.authorKaste, S. C.-
dc.date.accessioned2020-12-03T08:22:44Z-
dc.date.available2020-12-03T08:22:44Z-
dc.date.issued2011-
dc.identifier.citationBone Marrow Transplantation, 2011, v. 46, n. 6, p. 813-819-
dc.identifier.issn0268-3369-
dc.identifier.urihttp://hdl.handle.net/10722/294441-
dc.description.abstractOsteonecrosis (ON) is a debilitating long-term complication of allogeneic BMT (allo-BMT), but may begin before allo-BMT in some children because of their primary disease treatment. Therefore, to estimate the prevalence and associated risk factors for ON before allo-BMT, we conducted a retrospective analysis of magnetic resonance (MR) studies of 118 children who underwent first allo-BMT at our institution between December 2000 and September 2007. Of the 118 consecutive patients, 107 (90.7%) underwent prospective MR studies irrespective of symptoms (69 males; median age at allo-BMT 12.9 years), and 11 underwent MR studies for symptoms. Among the 107 who had prospective imaging, 23 (21.5%) had ON; nearly 50% had at least 30% epiphyseal involvement. Knees were more frequently involved than were hips; severity of ON was greater in hips. ON prevalence before allo-BMT was 23.72% when all 118 patients were included in the denominator. Risk factor analysis, limited to MR studies performed irrespective of symptoms, revealed female gender (P=0.049) and age ≥10 years at the time of MR study (P=0.03) as significant risk factors, and primary diagnosis of lymphoid malignancies and aplastic anemia trended toward significance. ON before allo-BMT is a common occurrence in children. © 2011 Macmillan Publishers Limited All rights reserved.-
dc.languageeng-
dc.relation.ispartofBone Marrow Transplantation-
dc.subjectallogeneic BMT-
dc.subjectosteonecrosis-
dc.subjectaplastic anemia-
dc.subjectchildren-
dc.subjectlymphphoid malignancies-
dc.titlePrevalence of osteonecrosis and associated risk factors in children before allogeneic BMT-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1038/bmt.2010.210-
dc.identifier.pmid20818446-
dc.identifier.pmcidPMC3010322-
dc.identifier.scopuseid_2-s2.0-79958098663-
dc.identifier.volume46-
dc.identifier.issue6-
dc.identifier.spage813-
dc.identifier.epage819-
dc.identifier.eissn1476-5365-
dc.identifier.isiWOS:000291383100006-
dc.identifier.issnl0268-3369-

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