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Article: Allogeneic bone marrow transplantation for children with histiocytic disorders: Use of TBI and omission of etoposide in the conditioning regimen

TitleAllogeneic bone marrow transplantation for children with histiocytic disorders: Use of TBI and omission of etoposide in the conditioning regimen
Authors
KeywordsTotal body irradiation
Langerhans cell histiocytosis
Allogeneic bone marrow transplantation
Hemophagocytic lymphohistiocytosis
Issue Date2003
Citation
Bone Marrow Transplantation, 2003, v. 31, n. 11, p. 981-986 How to Cite?
AbstractThe histiocytoses are rare disorders of antigen-processing phagocytic or antigen-presenting cells. Allogeneic bone marrow transplantation (BMT) can be curative of these disorders. We report a series of five children with Langerhans cell histiocytosis (n = 2) or hemophagocytic lymphohistiocytosis (n=3), who received allogeneic BMT with a total body irradiation (TBI)-containing regimen (TBI, cytarabine, and cyclophosphamide) at our institution between 1995 and 2000. One of these patients received busulfan, cyclophosphamide, and etoposide for the first of two BMTs. All grafts except one (a matched sibling-donor graft) were T-cell-depleted grafts from unrelated donors. All received cyclosporine graft-versus-host disease (GvHD) prophylaxis; the recipient of the matched sibling graft also received methotrexate. Three patients engrafted at a median of 24 days after transplantation. The patient who did not receive TBI experienced primary graft failure and recurrent disease. After the TBI-containing conditioning regimen was given, a second transplant engrafted on day + 17. One patient with concurrent myelodysplastic syndrome died of toxicity on day + 33 without evidence of engraftment. No acute or chronic GvHD was observed. Four patients survive disease-free, a median of 63 months after transplantation, all with Lansky performance scores of 100. We conclude that a conditioning regimen containing TBI but not etoposide is effective in allogeneic BMT for children with histiocytic diseases.
Persistent Identifierhttp://hdl.handle.net/10722/294400
ISSN
2023 Impact Factor: 4.5
2023 SCImago Journal Rankings: 1.318
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHale, G. A.-
dc.contributor.authorBowman, L. C.-
dc.contributor.authorWoodard, J. P.-
dc.contributor.authorCunningham, J. M.-
dc.contributor.authorBenaim, E.-
dc.contributor.authorHorwitz, E. M.-
dc.contributor.authorHeslop, H. E.-
dc.contributor.authorKrance, R. A.-
dc.contributor.authorLeung, W.-
dc.contributor.authorShearer, P. D.-
dc.contributor.authorHandgretinger, R.-
dc.date.accessioned2020-12-03T08:22:39Z-
dc.date.available2020-12-03T08:22:39Z-
dc.date.issued2003-
dc.identifier.citationBone Marrow Transplantation, 2003, v. 31, n. 11, p. 981-986-
dc.identifier.issn0268-3369-
dc.identifier.urihttp://hdl.handle.net/10722/294400-
dc.description.abstractThe histiocytoses are rare disorders of antigen-processing phagocytic or antigen-presenting cells. Allogeneic bone marrow transplantation (BMT) can be curative of these disorders. We report a series of five children with Langerhans cell histiocytosis (n = 2) or hemophagocytic lymphohistiocytosis (n=3), who received allogeneic BMT with a total body irradiation (TBI)-containing regimen (TBI, cytarabine, and cyclophosphamide) at our institution between 1995 and 2000. One of these patients received busulfan, cyclophosphamide, and etoposide for the first of two BMTs. All grafts except one (a matched sibling-donor graft) were T-cell-depleted grafts from unrelated donors. All received cyclosporine graft-versus-host disease (GvHD) prophylaxis; the recipient of the matched sibling graft also received methotrexate. Three patients engrafted at a median of 24 days after transplantation. The patient who did not receive TBI experienced primary graft failure and recurrent disease. After the TBI-containing conditioning regimen was given, a second transplant engrafted on day + 17. One patient with concurrent myelodysplastic syndrome died of toxicity on day + 33 without evidence of engraftment. No acute or chronic GvHD was observed. Four patients survive disease-free, a median of 63 months after transplantation, all with Lansky performance scores of 100. We conclude that a conditioning regimen containing TBI but not etoposide is effective in allogeneic BMT for children with histiocytic diseases.-
dc.languageeng-
dc.relation.ispartofBone Marrow Transplantation-
dc.subjectTotal body irradiation-
dc.subjectLangerhans cell histiocytosis-
dc.subjectAllogeneic bone marrow transplantation-
dc.subjectHemophagocytic lymphohistiocytosis-
dc.titleAllogeneic bone marrow transplantation for children with histiocytic disorders: Use of TBI and omission of etoposide in the conditioning regimen-
dc.typeArticle-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1038/sj.bmt.1704056-
dc.identifier.pmid12774048-
dc.identifier.scopuseid_2-s2.0-10744221069-
dc.identifier.volume31-
dc.identifier.issue11-
dc.identifier.spage981-
dc.identifier.epage986-
dc.identifier.isiWOS:000183298500005-
dc.identifier.issnl0268-3369-

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