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Article: Hypoxia-inducible factors and innate immunity in liver cancer

TitleHypoxia-inducible factors and innate immunity in liver cancer
Authors
Issue Date2020
PublisherAmerican Society for Clinical Investigation. The Journal's web site is located at http://www.jci.org
Citation
Journal of Clinical Investigation, 2020, v. 130 n. 10, p. 5052-5062 How to Cite?
AbstractThe liver has strong innate immunity to counteract pathogens from the gastrointestinal tract. During the development of liver cancer, which is typically driven by chronic inflammation, the composition and biological roles of the innate immune cells are extensively altered. Hypoxia is a common finding in all stages of liver cancer development. Hypoxia drives the stabilization of hypoxia-inducible factors (HIFs), which act as central regulators to dampen the innate immunity of liver cancer. HIF signaling in innate immune cells and liver cancer cells together favors the recruitment and maintenance of pro-tumorigenic immune cells and the inhibition of anti-tumorigenic immune cells, promoting immune evasion. HIFs represent attractive therapeutic targets to inhibit the formation of an immunosuppressive microenvironment and growth of liver cancer.
Persistent Identifierhttp://hdl.handle.net/10722/294202
ISSN
2023 Impact Factor: 13.3
2023 SCImago Journal Rankings: 4.833
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorYUEN, VWH-
dc.contributor.authorWong, CCL-
dc.date.accessioned2020-11-23T08:27:52Z-
dc.date.available2020-11-23T08:27:52Z-
dc.date.issued2020-
dc.identifier.citationJournal of Clinical Investigation, 2020, v. 130 n. 10, p. 5052-5062-
dc.identifier.issn0021-9738-
dc.identifier.urihttp://hdl.handle.net/10722/294202-
dc.description.abstractThe liver has strong innate immunity to counteract pathogens from the gastrointestinal tract. During the development of liver cancer, which is typically driven by chronic inflammation, the composition and biological roles of the innate immune cells are extensively altered. Hypoxia is a common finding in all stages of liver cancer development. Hypoxia drives the stabilization of hypoxia-inducible factors (HIFs), which act as central regulators to dampen the innate immunity of liver cancer. HIF signaling in innate immune cells and liver cancer cells together favors the recruitment and maintenance of pro-tumorigenic immune cells and the inhibition of anti-tumorigenic immune cells, promoting immune evasion. HIFs represent attractive therapeutic targets to inhibit the formation of an immunosuppressive microenvironment and growth of liver cancer.-
dc.languageeng-
dc.publisherAmerican Society for Clinical Investigation. The Journal's web site is located at http://www.jci.org-
dc.relation.ispartofJournal of Clinical Investigation-
dc.titleHypoxia-inducible factors and innate immunity in liver cancer-
dc.typeArticle-
dc.identifier.emailWong, CCL: carmencl@pathology.hku.hk-
dc.identifier.authorityWong, CCL=rp01602-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1172/JCI137553-
dc.identifier.pmid32750043-
dc.identifier.pmcidPMC7524494-
dc.identifier.scopuseid_2-s2.0-85092228166-
dc.identifier.hkuros319973-
dc.identifier.volume130-
dc.identifier.issue10-
dc.identifier.spage5052-
dc.identifier.epage5062-
dc.identifier.isiWOS:000582387500007-
dc.publisher.placeUnited States-
dc.identifier.issnl0021-9738-

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