File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1007/s43032-019-00115-3
- Scopus: eid_2-s2.0-85079619785
- PMID: 31942710
- WOS: WOS:000525432400002
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Mir-let-7a/g Enhances Uterine Receptivity via Suppressing Wnt/β-Catenin Under the Modulation of Ovarian Hormones
Title | Mir-let-7a/g Enhances Uterine Receptivity via Suppressing Wnt/β-Catenin Under the Modulation of Ovarian Hormones |
---|---|
Authors | |
Keywords | Mir-let-7a/g Uterine receptivity Estrogen Progesterone Wnt/β-catenin signaling |
Issue Date | 2020 |
Publisher | Sage Publications, Inc. The Journal's web site is located at http://rsx.sagepub.com |
Citation | Reproductive Sciences, 2020, v. 27, p. 1164-1174 How to Cite? |
Abstract | Microarray has indicated a huge number of miRNAs exist in reproductive tissues and cells. Moreover, the expression of miRNA in the reproductive system varies under the strict monitoring of different regulations. To understand the role of miRNA-mediated post-transcriptional gene regulation in female reproduction, we investigated the level and function of a mir-let-7 family member in both mice and human uterine receptivity. As we observed, mir-let-7 a/g had a higher expression in mouse and human receptive uterine epithelium; the level of mir-let-7a was under the inverse regulation of estrogen and progesterone; upregulated mir-let-7a/g in mouse and human uterine epithelium increased uterine receptivity, thus improved implantation-related embryo attachment and outgrowth ability; the let-7a/g enhanced uterine receptivity through suppressing canonical Wnt signaling. In summary, our findings suggest that mir-let-7 a/g increases uterine receptivity via inhibiting Wnt signaling and under the modulation of ovarian hormones. |
Persistent Identifier | http://hdl.handle.net/10722/294192 |
ISSN | 2023 Impact Factor: 2.6 2023 SCImago Journal Rankings: 0.836 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | LI, Q | - |
dc.contributor.author | Liu, W | - |
dc.contributor.author | Chiu, PCN | - |
dc.contributor.author | Yeung, WSB | - |
dc.date.accessioned | 2020-11-23T08:27:41Z | - |
dc.date.available | 2020-11-23T08:27:41Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Reproductive Sciences, 2020, v. 27, p. 1164-1174 | - |
dc.identifier.issn | 1933-7191 | - |
dc.identifier.uri | http://hdl.handle.net/10722/294192 | - |
dc.description.abstract | Microarray has indicated a huge number of miRNAs exist in reproductive tissues and cells. Moreover, the expression of miRNA in the reproductive system varies under the strict monitoring of different regulations. To understand the role of miRNA-mediated post-transcriptional gene regulation in female reproduction, we investigated the level and function of a mir-let-7 family member in both mice and human uterine receptivity. As we observed, mir-let-7 a/g had a higher expression in mouse and human receptive uterine epithelium; the level of mir-let-7a was under the inverse regulation of estrogen and progesterone; upregulated mir-let-7a/g in mouse and human uterine epithelium increased uterine receptivity, thus improved implantation-related embryo attachment and outgrowth ability; the let-7a/g enhanced uterine receptivity through suppressing canonical Wnt signaling. In summary, our findings suggest that mir-let-7 a/g increases uterine receptivity via inhibiting Wnt signaling and under the modulation of ovarian hormones. | - |
dc.language | eng | - |
dc.publisher | Sage Publications, Inc. The Journal's web site is located at http://rsx.sagepub.com | - |
dc.relation.ispartof | Reproductive Sciences | - |
dc.rights | Author(s), Contribution Title, Journal Title (Journal Volume Number and Issue Number) pp. xx-xx. Copyright © [year] (Copyright Holder). DOI: [DOI number]. | - |
dc.subject | Mir-let-7a/g | - |
dc.subject | Uterine receptivity | - |
dc.subject | Estrogen | - |
dc.subject | Progesterone | - |
dc.subject | Wnt/β-catenin signaling | - |
dc.title | Mir-let-7a/g Enhances Uterine Receptivity via Suppressing Wnt/β-Catenin Under the Modulation of Ovarian Hormones | - |
dc.type | Article | - |
dc.identifier.email | Liu, W: liuwm@hkucc.hku.hk | - |
dc.identifier.email | Chiu, PCN: pchiucn@hku.hk | - |
dc.identifier.email | Yeung, WSB: wsbyeung@hku.hk | - |
dc.identifier.authority | Chiu, PCN=rp00424 | - |
dc.identifier.authority | Yeung, WSB=rp00331 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1007/s43032-019-00115-3 | - |
dc.identifier.pmid | 31942710 | - |
dc.identifier.scopus | eid_2-s2.0-85079619785 | - |
dc.identifier.hkuros | 319408 | - |
dc.identifier.volume | 27 | - |
dc.identifier.spage | 1164 | - |
dc.identifier.epage | 1174 | - |
dc.identifier.isi | WOS:000525432400002 | - |
dc.publisher.place | United States | - |