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Article: Relationship Between Polyunsaturated Fatty Acids and Psychopathology in the NEURAPRO Clinical Trial

TitleRelationship Between Polyunsaturated Fatty Acids and Psychopathology in the NEURAPRO Clinical Trial
Authors
Keywordsultra-high risk
omega-3 fatty acids
psychosis
psychopathology
outcomes
Issue Date2019
PublisherFrontiers Research Foundation. The Journal's web site is located at https://www.frontiersin.org/journals/psychiatry
Citation
Frontiers in Psychiatry, 2019, v. 10, p. article no. 393 How to Cite?
AbstractBackground: Deficiencies in membrane polyunsaturated fatty acids (PUFA) such as omega-3 (n-3) fatty acids are thought to contribute to the pathophysiological processes underlying psychotic disorders. Emerging evidence suggests that the levels of PUFA are related to clinical symptoms but significant heterogeneity exists between studies. Here, we investigated associations of membrane PUFA with clinical symptoms and functioning in a large sample of individuals at ultra-high risk (UHR) for psychosis. Methods: A total of 285 participants of the NEURAPRO clinical trial were investigated for erythrocyte PUFA levels, including the n-3 index, n-6/n-3 PUFA ratio, docosahexaenoic acid (DHA), and eicosapentaenoic acid (EPA). Severity of general psychopathology [Brief Psychiatric Rating Scale (BPRS)], psychotic symptoms (BPRS psychosis subscale), negative symptoms [Scale for the Assessment of Negative Symptoms (SANS)], manic symptoms [Young Mania Rating Scale (YMRS)], depressive symptoms [Montgomery Asberg Depression Rating Scale (MADRS)], and functioning [Social and Occupational Functioning Scale (SOFAS), Global Functioning Social (GF-S) and Role (GF-R) scales] were assessed concurrently. Partial correlation taking into account the effects of gender, age, and smoking was used to examine the relationship between PUFAs and symptoms severity. Results: The n-3 index negatively correlated with the severity of general psychopathology, psychotic symptoms, depressive symptoms, and manic symptoms. The n-6/n-3 PUFA ratio positively correlated with severity of psychotic and depressive symptoms. The n-3 PUFA DHA negatively correlated with the severity of general psychopathology, positive, manic, and depressive symptoms. EPA negatively correlated with manic symptoms. Nervonic acid, an n-9 monounsaturated fatty acid, positively correlated with general psychopathology, positive and negative symptoms, depressive symptoms, and manic symptoms. The long-chain saturated fatty acid tetracosanoic acid positively correlated with general psychopathology, positive, manic, and depressive symptoms. Conclusions: Partially consistent with a previous study, psychotic symptoms, depressive symptoms, and symptoms of mania were associated with several classes of FAs in the present study. These findings support the relevance of membrane fatty acids for the onset of psychotic symptoms and indicate that FAs should be further evaluated as biomarkers in the UHR for psychosis group. Clinical Trial Registration: ANZCTR, identifier: 12608000475347
Persistent Identifierhttp://hdl.handle.net/10722/294140
ISSN
2023 Impact Factor: 3.2
2023 SCImago Journal Rankings: 1.155
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorBerger, M-
dc.contributor.authorNelson, B-
dc.contributor.authorMarkulev, C-
dc.contributor.authorYuen, HP-
dc.contributor.authorSchäfer, MR-
dc.contributor.authorMossaheb, N-
dc.contributor.authorSchlögelhofer, M-
dc.contributor.authorSmesny, S-
dc.contributor.authorHickie, IB-
dc.contributor.authorBerger, GE-
dc.contributor.authorChen, EYH-
dc.contributor.authorde Haan, L-
dc.contributor.authorNieman, DH-
dc.contributor.authorNordentoft, M-
dc.contributor.authorRiecher-Rössler, A-
dc.contributor.authorVerma, S-
dc.contributor.authorMitchell, TW-
dc.contributor.authorMeyer, BJ-
dc.contributor.authorThompson, A-
dc.contributor.authorYung, AR-
dc.contributor.authorMcGorry, PD-
dc.contributor.authorAmminger, GP-
dc.date.accessioned2020-11-23T08:26:56Z-
dc.date.available2020-11-23T08:26:56Z-
dc.date.issued2019-
dc.identifier.citationFrontiers in Psychiatry, 2019, v. 10, p. article no. 393-
dc.identifier.issn1664-0640-
dc.identifier.urihttp://hdl.handle.net/10722/294140-
dc.description.abstractBackground: Deficiencies in membrane polyunsaturated fatty acids (PUFA) such as omega-3 (n-3) fatty acids are thought to contribute to the pathophysiological processes underlying psychotic disorders. Emerging evidence suggests that the levels of PUFA are related to clinical symptoms but significant heterogeneity exists between studies. Here, we investigated associations of membrane PUFA with clinical symptoms and functioning in a large sample of individuals at ultra-high risk (UHR) for psychosis. Methods: A total of 285 participants of the NEURAPRO clinical trial were investigated for erythrocyte PUFA levels, including the n-3 index, n-6/n-3 PUFA ratio, docosahexaenoic acid (DHA), and eicosapentaenoic acid (EPA). Severity of general psychopathology [Brief Psychiatric Rating Scale (BPRS)], psychotic symptoms (BPRS psychosis subscale), negative symptoms [Scale for the Assessment of Negative Symptoms (SANS)], manic symptoms [Young Mania Rating Scale (YMRS)], depressive symptoms [Montgomery Asberg Depression Rating Scale (MADRS)], and functioning [Social and Occupational Functioning Scale (SOFAS), Global Functioning Social (GF-S) and Role (GF-R) scales] were assessed concurrently. Partial correlation taking into account the effects of gender, age, and smoking was used to examine the relationship between PUFAs and symptoms severity. Results: The n-3 index negatively correlated with the severity of general psychopathology, psychotic symptoms, depressive symptoms, and manic symptoms. The n-6/n-3 PUFA ratio positively correlated with severity of psychotic and depressive symptoms. The n-3 PUFA DHA negatively correlated with the severity of general psychopathology, positive, manic, and depressive symptoms. EPA negatively correlated with manic symptoms. Nervonic acid, an n-9 monounsaturated fatty acid, positively correlated with general psychopathology, positive and negative symptoms, depressive symptoms, and manic symptoms. The long-chain saturated fatty acid tetracosanoic acid positively correlated with general psychopathology, positive, manic, and depressive symptoms. Conclusions: Partially consistent with a previous study, psychotic symptoms, depressive symptoms, and symptoms of mania were associated with several classes of FAs in the present study. These findings support the relevance of membrane fatty acids for the onset of psychotic symptoms and indicate that FAs should be further evaluated as biomarkers in the UHR for psychosis group. Clinical Trial Registration: ANZCTR, identifier: 12608000475347-
dc.languageeng-
dc.publisherFrontiers Research Foundation. The Journal's web site is located at https://www.frontiersin.org/journals/psychiatry-
dc.relation.ispartofFrontiers in Psychiatry-
dc.rightsThis Document is Protected by copyright and was first published by Frontiers. All rights reserved. It is reproduced with permission.-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectultra-high risk-
dc.subjectomega-3 fatty acids-
dc.subjectpsychosis-
dc.subjectpsychopathology-
dc.subjectoutcomes-
dc.titleRelationship Between Polyunsaturated Fatty Acids and Psychopathology in the NEURAPRO Clinical Trial-
dc.typeArticle-
dc.identifier.emailChen, EYH: eyhchen@hku.hk-
dc.identifier.authorityChen, EYH=rp00392-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3389/fpsyt.2019.00393-
dc.identifier.pmid31244693-
dc.identifier.pmcidPMC6562242-
dc.identifier.scopuseid_2-s2.0-85069464635-
dc.identifier.hkuros320212-
dc.identifier.volume10-
dc.identifier.spagearticle no. 393-
dc.identifier.epagearticle no. 393-
dc.identifier.isiWOS:000471173900001-
dc.publisher.placeSwitzerland-
dc.identifier.issnl1664-0640-

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