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Article: Omega‐3 fatty acids and neurocognitive ability in young people at ultra‐high risk for psychosis

TitleOmega‐3 fatty acids and neurocognitive ability in young people at ultra‐high risk for psychosis
Authors
Keywordsneurocognition
omega-3
poly-unsaturated fatty acids
ultra-high risk
Issue Date2020
PublisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1751-7893
Citation
Early Intervention in Psychiatry, 2020, Epub 2020-09-06 How to Cite?
AbstractBackground: Neurocognitive impairments are core early features of psychosis and are observed in those at ultra-high risk (UHR) for psychosis. The aim of the present study was to explore whether neurocognition is associated with polyunsaturated fatty acids (PUFAs), as has been observed in other clinical populations. Method: Erythrocyte levels of total omega-3-and omega-6 PUFAs the omega-3/omega-6 ratio, were measured in 265 UHR individuals. Six domains of neurocognition as well a Composite Score, were assessed using the Brief Assessment of Cognition in Schizophrenia. Pearson's correlations were used to assess the relationship between PUFAs and neurocognition. All analyses were controlled for tobacco smoking. Results: Verbal Fluency correlated positively with eicosapentaenoic acid (P = .024) and alpha-linolenic acid (P = .01), and negatively with docosahexanoic acid (P = .007) and Working Memory positively correlated with omega-3/omega-6 ratio (P = .007). Conclusions: The current results provide support for a relationship between Verbal Fluency and omega-3 PUFAs in UHR. Further investigation is required to elucidate whether these biomarkers are useful as risk markers or in understanding the biological underpinning of neurocognitive impairment in this population.
Persistent Identifierhttp://hdl.handle.net/10722/294139
ISSN
2023 Impact Factor: 2.1
2023 SCImago Journal Rankings: 0.976
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorMcLaverty, A-
dc.contributor.authorAllott, KA-
dc.contributor.authorBerger, M-
dc.contributor.authorHester, R-
dc.contributor.authorMcGorry, PD-
dc.contributor.authorNelson, B-
dc.contributor.authorMarkulev, C-
dc.contributor.authorYuen, HP-
dc.contributor.authorSchäfer, MR-
dc.contributor.authorMossaheb, N-
dc.contributor.authorSchlögelhofer, M-
dc.contributor.authorSmesny, S-
dc.contributor.authorHickie, IB-
dc.contributor.authorBerger, GE-
dc.contributor.authorChen, EYH-
dc.contributor.authorde Haan, L-
dc.contributor.authorNieman, DH-
dc.contributor.authorNordentoft, M-
dc.contributor.authorRiecher‐Rössler, A-
dc.contributor.authorVerma, S-
dc.contributor.authorThompson, A-
dc.contributor.authorYung, AR-
dc.contributor.authorAmminger, GP-
dc.date.accessioned2020-11-23T08:26:55Z-
dc.date.available2020-11-23T08:26:55Z-
dc.date.issued2020-
dc.identifier.citationEarly Intervention in Psychiatry, 2020, Epub 2020-09-06-
dc.identifier.issn1751-7885-
dc.identifier.urihttp://hdl.handle.net/10722/294139-
dc.description.abstractBackground: Neurocognitive impairments are core early features of psychosis and are observed in those at ultra-high risk (UHR) for psychosis. The aim of the present study was to explore whether neurocognition is associated with polyunsaturated fatty acids (PUFAs), as has been observed in other clinical populations. Method: Erythrocyte levels of total omega-3-and omega-6 PUFAs the omega-3/omega-6 ratio, were measured in 265 UHR individuals. Six domains of neurocognition as well a Composite Score, were assessed using the Brief Assessment of Cognition in Schizophrenia. Pearson's correlations were used to assess the relationship between PUFAs and neurocognition. All analyses were controlled for tobacco smoking. Results: Verbal Fluency correlated positively with eicosapentaenoic acid (P = .024) and alpha-linolenic acid (P = .01), and negatively with docosahexanoic acid (P = .007) and Working Memory positively correlated with omega-3/omega-6 ratio (P = .007). Conclusions: The current results provide support for a relationship between Verbal Fluency and omega-3 PUFAs in UHR. Further investigation is required to elucidate whether these biomarkers are useful as risk markers or in understanding the biological underpinning of neurocognitive impairment in this population.-
dc.languageeng-
dc.publisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1751-7893-
dc.relation.ispartofEarly Intervention in Psychiatry-
dc.rightsSubmitted (preprint) Version This is the pre-peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. Accepted (peer-reviewed) Version This is the peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.-
dc.subjectneurocognition-
dc.subjectomega-3-
dc.subjectpoly-unsaturated fatty acids-
dc.subjectultra-high risk-
dc.titleOmega‐3 fatty acids and neurocognitive ability in young people at ultra‐high risk for psychosis-
dc.typeArticle-
dc.identifier.emailChen, EYH: eyhchen@hku.hk-
dc.identifier.authorityChen, EYH=rp00392-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/eip.13025-
dc.identifier.pmid32893462-
dc.identifier.scopuseid_2-s2.0-85090248853-
dc.identifier.hkuros320209-
dc.identifier.volumeEpub 2020-09-06-
dc.identifier.isiWOS:000566341800001-
dc.publisher.placeUnited States-

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