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Article: Chemical constituents from the thorns of Gleditsia sinensis and their cytotoxic activities

TitleChemical constituents from the thorns of Gleditsia sinensis and their cytotoxic activities
Authors
Zhang, YBLAM, KHChen, LFWAN, HWang, GCLee, CKYip, CWLiu, KHLeung, PHChen, HYShi, YGZhao, JLao, LXLi, YLZhang, YBMeng, W
KeywordsLeguminosae
Gleditsia sinensis
chemical constituent
structural identification
cytotoxic activity
Issue Date2020
PublisherTaylor & Francis Ltd. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/10286020.asp
Citation
Journal of Asian Natural Products Research, 2020, v. 22 n. 12, p. 1121-1129 How to Cite?
DOI: http://dx.doi.org/10.1080/10286020.2020.1731799
AbstractA new aromatic glycoside (1) and a new natural product, neolignan (2), along with twenty-three known compounds (3-25), were isolated from the thorns of Gleditsia sinensis. According to the spectroscopic analyses (IR, UV, HRESIMS, NMR and ECD), the structures of isolates were elucidated. Herein, compounds 4, 6-8, 10-13, 15, 16, 18, 20, 23 were isolated from the plant of G. sinensis for the first time. Moreover, compounds 4, 6, 15 and 24 showed cytotoxic effects on human ovarian cancer (SKOV-3) cells with IC50 values of 24.83 ± 4.90, 48.86 ± 9.11, 80.13 ± 5.62, 15.38 ± 2.21 μM, respectively.
Persistent Identifierhttp://hdl.handle.net/10722/294120
ISSN
1028-6020
2021 Impact Factor: 1.610
2020 SCImago Journal Rankings: 0.358
ISI Accession Number ID
WOS:000526508300001

 

DC FieldValueLanguage
dc.contributor.authorZhang, YB-
dc.contributor.authorLAM, KH-
dc.contributor.authorChen, LF-
dc.contributor.authorWAN, H-
dc.contributor.authorWang, GC-
dc.contributor.authorLee, CK-
dc.contributor.authorYip, CW-
dc.contributor.authorLiu, KH-
dc.contributor.authorLeung, PH-
dc.contributor.authorChen, HY-
dc.contributor.authorShi, YG-
dc.contributor.authorZhao, J-
dc.contributor.authorLao, LX-
dc.contributor.authorLi, YL-
dc.contributor.authorZhang, YB-
dc.contributor.authorMeng, W-
dc.date.accessioned2020-11-23T08:26:36Z-
dc.date.available2020-11-23T08:26:36Z-
dc.date.issued2020-
dc.identifier.citationJournal of Asian Natural Products Research, 2020, v. 22 n. 12, p. 1121-1129-
dc.identifier.issn1028-6020-
dc.identifier.urihttp://hdl.handle.net/10722/294120-
dc.description.abstractA new aromatic glycoside (1) and a new natural product, neolignan (2), along with twenty-three known compounds (3-25), were isolated from the thorns of Gleditsia sinensis. According to the spectroscopic analyses (IR, UV, HRESIMS, NMR and ECD), the structures of isolates were elucidated. Herein, compounds 4, 6-8, 10-13, 15, 16, 18, 20, 23 were isolated from the plant of G. sinensis for the first time. Moreover, compounds 4, 6, 15 and 24 showed cytotoxic effects on human ovarian cancer (SKOV-3) cells with IC50 values of 24.83 ± 4.90, 48.86 ± 9.11, 80.13 ± 5.62, 15.38 ± 2.21 μM, respectively.-
dc.languageeng-
dc.publisherTaylor & Francis Ltd. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/10286020.asp-
dc.relation.ispartofJournal of Asian Natural Products Research-
dc.rightsThis is an Accepted Manuscript of an article published by Taylor & Francis in [JOURNAL TITLE] on [date of publication], available online: http://www.tandfonline.com/[Article DOI].-
dc.subjectLeguminosae-
dc.subjectGleditsia sinensis-
dc.subjectchemical constituent-
dc.subjectstructural identification-
dc.subjectcytotoxic activity-
dc.titleChemical constituents from the thorns of Gleditsia sinensis and their cytotoxic activities-
dc.typeArticle-
dc.identifier.emailLee, CK: ckflee@hku.hk-
dc.identifier.emailLeung, PH: gphleung@hkucc.hku.hk-
dc.identifier.emailChen, HY: haiyong@hku.hk-
dc.identifier.emailShi, YG: shiyig@hkucc.hku.hk-
dc.identifier.emailZhao, J: zhaojia7@hku.hk-
dc.identifier.emailLao, LX: lxlao1@hku.hk-
dc.identifier.emailMeng, W: bmeng@hku.hk-
dc.identifier.authorityLee, CK=rp00458-
dc.identifier.authorityLeung, PH=rp00234-
dc.identifier.authorityChen, HY=rp01923-
dc.identifier.authorityLao, LX=rp01784-
dc.identifier.authorityZhang, YB=rp01410-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1080/10286020.2020.1731799-
dc.identifier.pmid32290704-
dc.identifier.scopuseid_2-s2.0-85083551027-
dc.identifier.hkuros319508-
dc.identifier.volume22-
dc.identifier.issue12-
dc.identifier.spage1121-
dc.identifier.epage1129-
dc.identifier.isiWOS:000526508300001-
dc.publisher.placeUnited Kingdom-

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