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Book Chapter: Metal complexes as drugs and therapeutic agents

TitleMetal complexes as drugs and therapeutic agents
Authors
Zhou, YIp, KYTZhang, QLi, HSun, H
KeywordsAntimicrobial therapy
Arsenic
Bismuth
Cancer therapy
Gallium
Issue Date2020
PublisherElsevier
Citation
Metal complexes as drugs and therapeutic agents. In Constable, EC, Parkin, G & Que, L (Eds.), Comprehensive Coordination Chemistry III (Third edition), v. 9 pt. 20, p. 680-705. Amsterdam: Elsevier, 2021 How to Cite?
DOI: http://dx.doi.org/10.1016/B978-0-08-102688-5.00018-0
AbstractMetal complexes have long been used in clinic for the treatment of a variety of diseases. The success of platinum-based anticancer drugs stimulates a large array of different metal-based drugs to be developed. Comprehensive characterization of these metallodrugs/metalloagents relevant to their therapeutic functions by sophisticated techniques including the integrative metalloproteomics approach will facilitate more rational drug design. This chapter summarizes the latest progress of (bio) coordination chemistry as well as anticancer and antimicrobial activities of the mostly studied metallodrugs/metalloagents. The uptake, trafficking, localization and molecular mechanisms of actions of representative complexes are also discussed.
Persistent Identifierhttp://hdl.handle.net/10722/294008
ISBN
9780124095472

 

DC FieldValueLanguage
dc.contributor.authorZhou, Y-
dc.contributor.authorIp, KYT-
dc.contributor.authorZhang, Q-
dc.contributor.authorLi, H-
dc.contributor.authorSun, H-
dc.date.accessioned2020-11-23T08:25:02Z-
dc.date.available2020-11-23T08:25:02Z-
dc.date.issued2020-
dc.identifier.citationMetal complexes as drugs and therapeutic agents. In Constable, EC, Parkin, G & Que, L (Eds.), Comprehensive Coordination Chemistry III (Third edition), v. 9 pt. 20, p. 680-705. Amsterdam: Elsevier, 2021-
dc.identifier.isbn9780124095472-
dc.identifier.urihttp://hdl.handle.net/10722/294008-
dc.description.abstractMetal complexes have long been used in clinic for the treatment of a variety of diseases. The success of platinum-based anticancer drugs stimulates a large array of different metal-based drugs to be developed. Comprehensive characterization of these metallodrugs/metalloagents relevant to their therapeutic functions by sophisticated techniques including the integrative metalloproteomics approach will facilitate more rational drug design. This chapter summarizes the latest progress of (bio) coordination chemistry as well as anticancer and antimicrobial activities of the mostly studied metallodrugs/metalloagents. The uptake, trafficking, localization and molecular mechanisms of actions of representative complexes are also discussed.-
dc.languageeng-
dc.publisherElsevier-
dc.relation.ispartofComprehensive Coordination Chemistry III (Third edition)-
dc.subjectAntimicrobial therapy-
dc.subjectArsenic-
dc.subjectBismuth-
dc.subjectCancer therapy-
dc.subjectGallium-
dc.titleMetal complexes as drugs and therapeutic agents-
dc.typeBook_Chapter-
dc.identifier.emailZhou, Y: zy2018@connect.hku.hk-
dc.identifier.emailLi, H: hylichem@hku.hk-
dc.identifier.emailSun, H: hsun@hku.hk-
dc.identifier.authoritySun, H=rp00777-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/B978-0-08-102688-5.00018-0-
dc.identifier.scopuseid_2-s2.0-85129965964-
dc.identifier.hkuros318966-
dc.identifier.issuev. 9 pt. 20-
dc.identifier.spage680-
dc.identifier.epage705-
dc.publisher.placeAmsterdam-

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