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Article: Anti-cancer effects of polyphenols via targeting p53 signaling pathway: updates and future directions

TitleAnti-cancer effects of polyphenols via targeting p53 signaling pathway: updates and future directions
Authors
Khan, HReale, MUllah, HSureda, ATejada, SWang, YZhang, ZJXiao, J
KeywordsPolyphenols
Anticancer
p53 signaling pathways
Clinical perspectives
Chemoresistance
Issue Date2020
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/biotechadv
Citation
Biotechnology Advances, 2020, v. 38, p. article no. 107385 How to Cite?
DOI: http://dx.doi.org/10.1016/j.biotechadv.2019.04.007
AbstractThe anticancer effects of polyphenols are ascribed to several signaling pathways including the tumor suppressor gene tumor protein 53 (p53). Expression of endogenous p53 is silent in various types of cancers. A number of polyphenols from a wide variety of dietary sources could upregulate p53 expression in several cancer cell lines through distinct mechanisms of action. The aim of this review is to focus the significance of p53 signaling pathways and to provide molecular intuitions of dietary polyphenols in chemoprevention by monitoring p53 expression that have a prominent role in tumor suppression.
Persistent Identifierhttp://hdl.handle.net/10722/293948
ISSN
0734-9750
2023 Impact Factor: 12.1
2023 SCImago Journal Rankings: 2.521
ISI Accession Number ID
WOS:000514012700003

 

DC FieldValueLanguage
dc.contributor.authorKhan, H-
dc.contributor.authorReale, M-
dc.contributor.authorUllah, H-
dc.contributor.authorSureda, A-
dc.contributor.authorTejada, S-
dc.contributor.authorWang, Y-
dc.contributor.authorZhang, ZJ-
dc.contributor.authorXiao, J-
dc.date.accessioned2020-11-23T08:24:10Z-
dc.date.available2020-11-23T08:24:10Z-
dc.date.issued2020-
dc.identifier.citationBiotechnology Advances, 2020, v. 38, p. article no. 107385-
dc.identifier.issn0734-9750-
dc.identifier.urihttp://hdl.handle.net/10722/293948-
dc.description.abstractThe anticancer effects of polyphenols are ascribed to several signaling pathways including the tumor suppressor gene tumor protein 53 (p53). Expression of endogenous p53 is silent in various types of cancers. A number of polyphenols from a wide variety of dietary sources could upregulate p53 expression in several cancer cell lines through distinct mechanisms of action. The aim of this review is to focus the significance of p53 signaling pathways and to provide molecular intuitions of dietary polyphenols in chemoprevention by monitoring p53 expression that have a prominent role in tumor suppression.-
dc.languageeng-
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/biotechadv-
dc.relation.ispartofBiotechnology Advances-
dc.subjectPolyphenols-
dc.subjectAnticancer-
dc.subjectp53 signaling pathways-
dc.subjectClinical perspectives-
dc.subjectChemoresistance-
dc.titleAnti-cancer effects of polyphenols via targeting p53 signaling pathway: updates and future directions-
dc.typeArticle-
dc.identifier.emailZhang, ZJ: zhangzj@hkucc.hku.hk-
dc.identifier.authorityZhang, ZJ=rp01297-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.biotechadv.2019.04.007-
dc.identifier.pmid31004736-
dc.identifier.scopuseid_2-s2.0-85064437785-
dc.identifier.hkuros319629-
dc.identifier.volume38-
dc.identifier.spagearticle no. 107385-
dc.identifier.epagearticle no. 107385-
dc.identifier.isiWOS:000514012700003-
dc.publisher.placeUnited States-
dc.identifier.issnl0734-9750-

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