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- Publisher Website: 10.1186/s12943-020-01172-y
- Scopus: eid_2-s2.0-85080969170
- PMID: 32111216
- WOS: WOS:000518909200002
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Article: The emerging roles of N6-methyladenosine (m6A) deregulation in liver carcinogenesis
Title | The emerging roles of N6-methyladenosine (m6A) deregulation in liver carcinogenesis |
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Authors | |
Keywords | Hepatocellular carcinoma N6-methyladenosine RNA epigenetics Epi-transcriptome |
Issue Date | 2020 |
Publisher | BioMed Central Ltd. The Journal's web site is located at http://www.molecular-cancer.com |
Citation | Molecular Cancer, 2020, v. 19, p. article no. 44 How to Cite? |
Abstract | Liver cancer is a common cancer worldwide. Although the etiological factors of liver carcinogenesis are well defined, the underlying molecular mechanisms remain largely elusive. Epigenetic deregulations, such as aberrant DNA methylation and histone modifications, play a critical role in liver carcinogenesis. Analogous to DNA and core histone proteins, reversible chemical modifications on mRNA have recently been recognized as important regulatory mechanisms to control gene expression. N6-methyladenosine (m6A) is the most prevalent internal mRNA modification in mammalian cells. m6A modification is important for controlling many cellular and biological processes. Deregulation of m6A modification has been recently implicated in human carcinogenesis, including liver cancer. In this review, we summarize the recent findings on m6A regulation and its biological impacts in normal and cancer cells. We will focus on the deregulation of m6A modification and m6A regulators in liver diseases and liver cancers. We will highlight the clinical relevance of m6A deregulation in liver cancer. We will also discuss the potential of exploiting m6A modification for cancer diagnosis and therapeutics. |
Description | Hepatocellular carcinoma |
Persistent Identifier | http://hdl.handle.net/10722/293873 |
ISSN | 2023 Impact Factor: 27.7 2023 SCImago Journal Rankings: 8.222 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Chen, M | - |
dc.contributor.author | Wong, CM | - |
dc.date.accessioned | 2020-11-23T08:23:02Z | - |
dc.date.available | 2020-11-23T08:23:02Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Molecular Cancer, 2020, v. 19, p. article no. 44 | - |
dc.identifier.issn | 1476-4598 | - |
dc.identifier.uri | http://hdl.handle.net/10722/293873 | - |
dc.description | Hepatocellular carcinoma | - |
dc.description.abstract | Liver cancer is a common cancer worldwide. Although the etiological factors of liver carcinogenesis are well defined, the underlying molecular mechanisms remain largely elusive. Epigenetic deregulations, such as aberrant DNA methylation and histone modifications, play a critical role in liver carcinogenesis. Analogous to DNA and core histone proteins, reversible chemical modifications on mRNA have recently been recognized as important regulatory mechanisms to control gene expression. N6-methyladenosine (m6A) is the most prevalent internal mRNA modification in mammalian cells. m6A modification is important for controlling many cellular and biological processes. Deregulation of m6A modification has been recently implicated in human carcinogenesis, including liver cancer. In this review, we summarize the recent findings on m6A regulation and its biological impacts in normal and cancer cells. We will focus on the deregulation of m6A modification and m6A regulators in liver diseases and liver cancers. We will highlight the clinical relevance of m6A deregulation in liver cancer. We will also discuss the potential of exploiting m6A modification for cancer diagnosis and therapeutics. | - |
dc.language | eng | - |
dc.publisher | BioMed Central Ltd. The Journal's web site is located at http://www.molecular-cancer.com | - |
dc.relation.ispartof | Molecular Cancer | - |
dc.rights | Molecular Cancer. Copyright © BioMed Central Ltd. | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Hepatocellular carcinoma | - |
dc.subject | N6-methyladenosine | - |
dc.subject | RNA epigenetics | - |
dc.subject | Epi-transcriptome | - |
dc.title | The emerging roles of N6-methyladenosine (m6A) deregulation in liver carcinogenesis | - |
dc.type | Article | - |
dc.identifier.email | Wong, CM: jcmwong@hku.hk | - |
dc.identifier.authority | Wong, CM=rp00231 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1186/s12943-020-01172-y | - |
dc.identifier.pmid | 32111216 | - |
dc.identifier.pmcid | PMC7047367 | - |
dc.identifier.scopus | eid_2-s2.0-85080969170 | - |
dc.identifier.hkuros | 320057 | - |
dc.identifier.volume | 19 | - |
dc.identifier.spage | article no. 44 | - |
dc.identifier.epage | article no. 44 | - |
dc.identifier.isi | WOS:000518909200002 | - |
dc.publisher.place | United Kingdom | - |