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Article: Dysplasia and DNA Ploidy to Prognosticate Clinical Outcome in Oral Potentially Malignant Disorders

TitleDysplasia and DNA Ploidy to Prognosticate Clinical Outcome in Oral Potentially Malignant Disorders
Authors
KeywordsDNA ploidy
dysplasia
leukoplakia
malignant
oral potentially malignant disorder
Issue Date2021
PublisherWiley-Blackwell Publishing Ltd. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1600-0714
Citation
Journal of Oral Pathology & Medicine, 2021, v. 50 n. 2, p. 200-209 How to Cite?
AbstractBackground: Oral potentially malignant disorders are a clinical conundrum as there are no reliable methods to predict their behaviour. We combine conventional oral epithelial dysplasia grading with DNA ploidy analysis to examine the validity of this approach to risk assessment in a cohort of patients with known clinical outcomes. Methods: Sections from diagnostic biopsies were assessed for oral epithelial dysplasia using the WHO grading system, and DNA ploidy analysis was performed using established methods. Patients reviewed for a minimum of 5 years who did not develop oral squamous cell carcinoma were classified as “non-transforming” cases. Patients that developed oral squamous cell carcinoma ≥ 6 months after the initial diagnostic biopsy were classified as having “malignant transformation.” Results: Ninety cases were included in the study. Seventy cases yielded informative DNA ploidy results. Of these 70 cases, 31 progressed to cancer. Oral epithelial dysplasia grading and DNA ploidy status were both significantly associated with clinical outcome (P < 0.05). Severe dysplasia had a hazard ratio of 3.50 (CI: 1.46, 8.45; P = 0.005) compared to cases with mild dysplasia. Aneuploidy had a hazard ratio of 2.09 (CI: 1.01, 4.32; P = 0.046) compared to cases with a diploid/tetraploid status. Receiver operating characteristic analysis gave an area under the curve of 0.617 for DNA ploidy status and 0.688 when DNA ploidy status was combined with dysplasia grading. Conclusion: Our findings suggest that combining dysplasia grading with DNA ploidy status has clinical utility which could be used to develop novel management algorithms.
Persistent Identifierhttp://hdl.handle.net/10722/293808
ISSN
2023 Impact Factor: 2.7
2023 SCImago Journal Rankings: 0.716
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorSathasivam, HP-
dc.contributor.authorNayar, D-
dc.contributor.authorSloan, P-
dc.contributor.authorThomson, PJ-
dc.contributor.authorOdell, EW-
dc.contributor.authorRobinson, M-
dc.date.accessioned2020-11-23T08:22:05Z-
dc.date.available2020-11-23T08:22:05Z-
dc.date.issued2021-
dc.identifier.citationJournal of Oral Pathology & Medicine, 2021, v. 50 n. 2, p. 200-209-
dc.identifier.issn0904-2512-
dc.identifier.urihttp://hdl.handle.net/10722/293808-
dc.description.abstractBackground: Oral potentially malignant disorders are a clinical conundrum as there are no reliable methods to predict their behaviour. We combine conventional oral epithelial dysplasia grading with DNA ploidy analysis to examine the validity of this approach to risk assessment in a cohort of patients with known clinical outcomes. Methods: Sections from diagnostic biopsies were assessed for oral epithelial dysplasia using the WHO grading system, and DNA ploidy analysis was performed using established methods. Patients reviewed for a minimum of 5 years who did not develop oral squamous cell carcinoma were classified as “non-transforming” cases. Patients that developed oral squamous cell carcinoma ≥ 6 months after the initial diagnostic biopsy were classified as having “malignant transformation.” Results: Ninety cases were included in the study. Seventy cases yielded informative DNA ploidy results. Of these 70 cases, 31 progressed to cancer. Oral epithelial dysplasia grading and DNA ploidy status were both significantly associated with clinical outcome (P < 0.05). Severe dysplasia had a hazard ratio of 3.50 (CI: 1.46, 8.45; P = 0.005) compared to cases with mild dysplasia. Aneuploidy had a hazard ratio of 2.09 (CI: 1.01, 4.32; P = 0.046) compared to cases with a diploid/tetraploid status. Receiver operating characteristic analysis gave an area under the curve of 0.617 for DNA ploidy status and 0.688 when DNA ploidy status was combined with dysplasia grading. Conclusion: Our findings suggest that combining dysplasia grading with DNA ploidy status has clinical utility which could be used to develop novel management algorithms.-
dc.languageeng-
dc.publisherWiley-Blackwell Publishing Ltd. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1600-0714-
dc.relation.ispartofJournal of Oral Pathology & Medicine-
dc.rightsSubmitted (preprint) Version This is the pre-peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. Accepted (peer-reviewed) Version This is the peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.-
dc.subjectDNA ploidy-
dc.subjectdysplasia-
dc.subjectleukoplakia-
dc.subjectmalignant-
dc.subjectoral potentially malignant disorder-
dc.titleDysplasia and DNA Ploidy to Prognosticate Clinical Outcome in Oral Potentially Malignant Disorders-
dc.typeArticle-
dc.identifier.emailThomson, PJ: thomsonp@hku.hk-
dc.identifier.authorityThomson, PJ=rp02327-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/jop.13121-
dc.identifier.pmid33151583-
dc.identifier.scopuseid_2-s2.0-85099055830-
dc.identifier.hkuros319175-
dc.identifier.volume50-
dc.identifier.issue2-
dc.identifier.spage200-
dc.identifier.epage209-
dc.identifier.isiWOS:000604705900001-
dc.publisher.placeDenmark-

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