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Article: Outcome of vaginal stripping for vaginal intraepithelial neoplasia: A 20‐year observational study

TitleOutcome of vaginal stripping for vaginal intraepithelial neoplasia: A 20‐year observational study
Authors
Keywordspapillomavirus infection
vaginal neoplasm
Cytology and GYN Pathology (3112 )
Issue Date2020
PublisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.wiley.com/WileyCDA/WileyTitle/productCd-JOG.html
Citation
Journal of Obstetrics and Gynaecology Research, 2020, v. 46 n. 12, p. 2511-2517 How to Cite?
AbstractAim: High-grade vaginal intraepithelial neoplasia (VAIN) is considered to be a premalignant lesion. We conducted a 20-year retrospective observational single-center study on the effectiveness of vaginal stripping (local excision procedure) as a treatment for high-grade VAIN. Methods: Women diagnosed with VAIN and treated with vaginal stripping performed from 1998 to 2017 at our unit were identified using the hospital computer database. Vaginal stripping was performed for high-grade VAIN after being diagnosed by colposcopy-directed biopsies. The patients were followed every 3–6 months afterward via cytology monitoring and vaginal smear. Colposcopy-guided biopsy was repeated for high-grade abnormal cytology or persistent low-grade abnormality. The residual disease and recurrence rates were determined. Risk factors for margin positivity and residual and recurrent disease were identified. The association between margin positivity and recurrence was evaluated. Results: Excluding three women whose final histology were malignant, the follow-up smears and histology (if any) were traced in the remaining 111 women. The median follow-up time was 76 months. Twenty-one of them had persistent abnormal smears (14 high-grade lesions and seven low-grade lesions) during the year following the vaginal stripping. The residual disease rate was 18.9% (21/111). The recurrence rate was 7.2%. There were five women (4%) with procedure-related complications. History of hysterectomy was identified as a risk factor for recurrence. Conclusions: Vaginal stripping is a valid treatment option for VAIN. High-grade VAIN post treatment recurred up to 5 years post treatment. Regular long-term surveillance is needed.
Persistent Identifierhttp://hdl.handle.net/10722/293768
ISSN
2023 Impact Factor: 1.6
2023 SCImago Journal Rankings: 0.576
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChai, YK-
dc.contributor.authorCheung, SYC-
dc.contributor.authorChan, KKL-
dc.date.accessioned2020-11-23T08:21:32Z-
dc.date.available2020-11-23T08:21:32Z-
dc.date.issued2020-
dc.identifier.citationJournal of Obstetrics and Gynaecology Research, 2020, v. 46 n. 12, p. 2511-2517-
dc.identifier.issn1341-8076-
dc.identifier.urihttp://hdl.handle.net/10722/293768-
dc.description.abstractAim: High-grade vaginal intraepithelial neoplasia (VAIN) is considered to be a premalignant lesion. We conducted a 20-year retrospective observational single-center study on the effectiveness of vaginal stripping (local excision procedure) as a treatment for high-grade VAIN. Methods: Women diagnosed with VAIN and treated with vaginal stripping performed from 1998 to 2017 at our unit were identified using the hospital computer database. Vaginal stripping was performed for high-grade VAIN after being diagnosed by colposcopy-directed biopsies. The patients were followed every 3–6 months afterward via cytology monitoring and vaginal smear. Colposcopy-guided biopsy was repeated for high-grade abnormal cytology or persistent low-grade abnormality. The residual disease and recurrence rates were determined. Risk factors for margin positivity and residual and recurrent disease were identified. The association between margin positivity and recurrence was evaluated. Results: Excluding three women whose final histology were malignant, the follow-up smears and histology (if any) were traced in the remaining 111 women. The median follow-up time was 76 months. Twenty-one of them had persistent abnormal smears (14 high-grade lesions and seven low-grade lesions) during the year following the vaginal stripping. The residual disease rate was 18.9% (21/111). The recurrence rate was 7.2%. There were five women (4%) with procedure-related complications. History of hysterectomy was identified as a risk factor for recurrence. Conclusions: Vaginal stripping is a valid treatment option for VAIN. High-grade VAIN post treatment recurred up to 5 years post treatment. Regular long-term surveillance is needed.-
dc.languageeng-
dc.publisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.wiley.com/WileyCDA/WileyTitle/productCd-JOG.html-
dc.relation.ispartofJournal of Obstetrics and Gynaecology Research-
dc.rightsSubmitted (preprint) Version This is the pre-peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. Accepted (peer-reviewed) Version This is the peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.-
dc.subjectpapillomavirus infection-
dc.subjectvaginal neoplasm-
dc.subjectCytology and GYN Pathology (3112 )-
dc.titleOutcome of vaginal stripping for vaginal intraepithelial neoplasia: A 20‐year observational study-
dc.typeArticle-
dc.identifier.emailChai, YK: chaiyk@hku.hk-
dc.identifier.emailCheung, SYC: csy088@hku.hk-
dc.identifier.emailChan, KKL: kklchan@hkucc.hku.hk-
dc.identifier.authorityChan, KKL=rp00499-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1111/jog.14482-
dc.identifier.pmid32924254-
dc.identifier.scopuseid_2-s2.0-85090967776-
dc.identifier.hkuros319255-
dc.identifier.volume46-
dc.identifier.issue12-
dc.identifier.spage2511-
dc.identifier.epage2517-
dc.identifier.isiWOS:000568638500001-
dc.publisher.placeAustralia-

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