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Article: Metagenomic Analysis Revealing Antibiotic Resistance Genes (ARGs) and Their Genetic Compartments in the Tibetan Environment

TitleMetagenomic Analysis Revealing Antibiotic Resistance Genes (ARGs) and Their Genetic Compartments in the Tibetan Environment
Authors
KeywordsAnimal wastes
Antibiotic resistance
Antibiotic resistance genes
Bacterial community structure
Beta-lactams
Issue Date2016
PublisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/journal/esthag
Citation
Environmental Science & Technology, 2016, v. 50 n. 13, p. 6670-6679 How to Cite?
AbstractComprehensive profiles of antibiotic resistance genes (ARGs) and mobile genetic elements (MGEs) in a minimally impacted environment are essential to understanding the evolution and dissemination of modern antibiotic resistance. Chemical analyses of the samples collected from Tibet demonstrated that the region under investigation was almost devoid of anthropogenic antibiotics. The soils, animal wastes, and sediments were different from each other in terms of bacterial community structures, and in the typical profiles of ARGs and MGEs. Diverse ARGs that encoded resistance to common antibiotics (e.g., beta-lactams, fluoroquinolones, etc.) were found mainly via an efflux mechanism completely distinct from modern antibiotic resistome. In addition, a very small fraction of ARGs in the Tibetan environment were carried by MGEs, indicating the low potential of these ARGs to be transferred among bacteria. In comparison to the ARG profiles in relatively pristine Tibet, contemporary ARGs and MGEs in human-impacted environments have evolved substantially since the broad use of anthropogenic antibiotics.
Persistent Identifierhttp://hdl.handle.net/10722/293672
ISSN
2023 Impact Factor: 10.8
2023 SCImago Journal Rankings: 3.516
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChen, B-
dc.contributor.authorYuan, K-
dc.contributor.authorChen, X-
dc.contributor.authorYang, Y-
dc.contributor.authorZhang, T-
dc.contributor.authorWang, Y-
dc.contributor.authorLuan, T-
dc.contributor.authorZou, S-
dc.contributor.authorLi, X-
dc.date.accessioned2020-11-23T08:20:09Z-
dc.date.available2020-11-23T08:20:09Z-
dc.date.issued2016-
dc.identifier.citationEnvironmental Science & Technology, 2016, v. 50 n. 13, p. 6670-6679-
dc.identifier.issn0013-936X-
dc.identifier.urihttp://hdl.handle.net/10722/293672-
dc.description.abstractComprehensive profiles of antibiotic resistance genes (ARGs) and mobile genetic elements (MGEs) in a minimally impacted environment are essential to understanding the evolution and dissemination of modern antibiotic resistance. Chemical analyses of the samples collected from Tibet demonstrated that the region under investigation was almost devoid of anthropogenic antibiotics. The soils, animal wastes, and sediments were different from each other in terms of bacterial community structures, and in the typical profiles of ARGs and MGEs. Diverse ARGs that encoded resistance to common antibiotics (e.g., beta-lactams, fluoroquinolones, etc.) were found mainly via an efflux mechanism completely distinct from modern antibiotic resistome. In addition, a very small fraction of ARGs in the Tibetan environment were carried by MGEs, indicating the low potential of these ARGs to be transferred among bacteria. In comparison to the ARG profiles in relatively pristine Tibet, contemporary ARGs and MGEs in human-impacted environments have evolved substantially since the broad use of anthropogenic antibiotics.-
dc.languageeng-
dc.publisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/journal/esthag-
dc.relation.ispartofEnvironmental Science & Technology-
dc.rightsThis document is the Accepted Manuscript version of a Published Work that appeared in final form in [JournalTitle], copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see [insert ACS Articles on Request author-directed link to Published Work, see http://pubs.acs.org/page/policy/articlesonrequest/index.html].-
dc.subjectAnimal wastes-
dc.subjectAntibiotic resistance-
dc.subjectAntibiotic resistance genes-
dc.subjectBacterial community structure-
dc.subjectBeta-lactams-
dc.titleMetagenomic Analysis Revealing Antibiotic Resistance Genes (ARGs) and Their Genetic Compartments in the Tibetan Environment-
dc.typeArticle-
dc.identifier.emailZhang, T: zhangt@hkucc.hku.hk-
dc.identifier.authorityZhang, T=rp00211-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1021/acs.est.6b00619-
dc.identifier.pmid27111002-
dc.identifier.scopuseid_2-s2.0-84979084828-
dc.identifier.hkuros319462-
dc.identifier.volume50-
dc.identifier.issue13-
dc.identifier.spage6670-
dc.identifier.epage6679-
dc.identifier.isiWOS:000379366300012-
dc.publisher.placeUnited States-
dc.identifier.issnl0013-936X-

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