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Article: Membrane heist: Coronavirus host membrane remodeling during replication

TitleMembrane heist: Coronavirus host membrane remodeling during replication
Authors
KeywordsCoronavirus
Double membrane vesicles
Lipid metabolism
Issue Date2020
PublisherElsevier France, Editions Scientifiques et Medicales. The Journal's web site is located at http://www.elsevier.com/locate/biochi
Citation
Biochimie, 2020, v. 179, p. 229-236 How to Cite?
AbstractThe ongoing pandemic of COVID-19 (Coronavirus Disease-2019), a respiratory disease caused by the novel coronavirus strain, SARS-CoV-2, has affected more than 42 million people already, with more than one million deaths worldwide (as of October 25, 2020). We are in urgent need of therapeutic interventions that target the host-virus interface, which requires a molecular understanding of the SARS-CoV-2 life-cycle. Like other positive-sense RNA viruses, coronaviruses remodel intracellular membranes to form specialized viral replication compartments, including double-membrane vesicles (DMVs), where viral RNA genome replication takes place. Here we review the current knowledge of the structure, lipid composition, function, and biogenesis of coronavirus-induced DMVs, highlighting the druggable viral and cellular factors that are involved in the formation and function of DMVs.
Persistent Identifierhttp://hdl.handle.net/10722/293657
ISSN
2019 Impact Factor: 3.413
2015 SCImago Journal Rankings: 1.462
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZhang, J-
dc.contributor.authorLan, Y-
dc.contributor.authorSanyal, S-
dc.date.accessioned2020-11-23T08:19:56Z-
dc.date.available2020-11-23T08:19:56Z-
dc.date.issued2020-
dc.identifier.citationBiochimie, 2020, v. 179, p. 229-236-
dc.identifier.issn0300-9084-
dc.identifier.urihttp://hdl.handle.net/10722/293657-
dc.description.abstractThe ongoing pandemic of COVID-19 (Coronavirus Disease-2019), a respiratory disease caused by the novel coronavirus strain, SARS-CoV-2, has affected more than 42 million people already, with more than one million deaths worldwide (as of October 25, 2020). We are in urgent need of therapeutic interventions that target the host-virus interface, which requires a molecular understanding of the SARS-CoV-2 life-cycle. Like other positive-sense RNA viruses, coronaviruses remodel intracellular membranes to form specialized viral replication compartments, including double-membrane vesicles (DMVs), where viral RNA genome replication takes place. Here we review the current knowledge of the structure, lipid composition, function, and biogenesis of coronavirus-induced DMVs, highlighting the druggable viral and cellular factors that are involved in the formation and function of DMVs.-
dc.languageeng-
dc.publisherElsevier France, Editions Scientifiques et Medicales. The Journal's web site is located at http://www.elsevier.com/locate/biochi-
dc.relation.ispartofBiochimie-
dc.subjectCoronavirus-
dc.subjectDouble membrane vesicles-
dc.subjectLipid metabolism-
dc.titleMembrane heist: Coronavirus host membrane remodeling during replication-
dc.typeArticle-
dc.identifier.emailLan, Y: yunlan@connect.hku.hk-
dc.identifier.emailSanyal, S: sanyal@hku.hk-
dc.identifier.authoritySanyal, S=rp01794-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1016/j.biochi.2020.10.010-
dc.identifier.pmid33115667-
dc.identifier.pmcidPMC7585727-
dc.identifier.scopuseid_2-s2.0-85094869587-
dc.identifier.hkuros319850-
dc.identifier.volume179-
dc.identifier.spage229-
dc.identifier.epage236-
dc.identifier.isiWOS:000600799000023-
dc.publisher.placeFrance-

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