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Article: Assessor‐ and participant‐blinded, randomized controlled trial of dense cranial electroacupuncture stimulation plus body acupuncture for neuropsychiatric sequelae of stroke

TitleAssessor‐ and participant‐blinded, randomized controlled trial of dense cranial electroacupuncture stimulation plus body acupuncture for neuropsychiatric sequelae of stroke
Authors
Keywordsacupuncture
cognitive impairment
dense cranial electroacupuncture stimulation (DCEAS)
functional disability
poststroke depression
Issue Date2020
PublisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1440-1819
Citation
Psychiatry and Clinical Neurosciences, 2020, v. 74 n. 3, p. 183-190 How to Cite?
AbstractAim: Acupuncture has benefits in the rehabilitation of neuropsychiatric sequelae of stroke. This study was aimed to evaluate the effectiveness of dense cranial electroacupuncture stimulation plus body acupuncture (DCEAS+BA) in treating poststroke depression (PSD), functional disability, and cognitive deterioration. Methods: In this assessor‐ and participant‐blinded, randomized controlled trial, 91 stroke patients who initially had PSD were randomly assigned to either DCEAS+BA (n = 45) or minimum acupuncture stimulation as controls (n = 46) for three sessions per week over 8 consecutive weeks. The primary outcome was baseline‐to‐end‐point change in score of the 17‐item Hamilton Depression Rating Scale. Secondary outcomes included the Montgomery–Åsberg Depression Rating Scale for depressive symptoms, the Barthel Index for functional disability, and the Montreal Cognitive Assessment for cognitive function. Results: DCEAS+BA‐treated patients showed strikingly greater end‐point reduction than MAS‐treated patients in scores of the three symptom domains. The clinical response rate, defined as an at least 50% baseline‐to‐end‐point reduction in 17‐item Hamilton Depression Rating Scale score, was markedly higher in the DCEAS+BA‐treated group than that of controls (40.0% vs 17.4%, P = 0.031). Incidence of adverse events was not different in the two groups. Subgroup analysis revealed that DCEAS+BA with electrical stimulation on forehead acupoints was more apparent in reducing Barthel‐Index‐measured disability than that without electrical stimulation. Conclusion: DCEAS+BA, particularly with electrical stimulation on forehead acupoints, reduces PSD, functional disability, and cognitive deterioration of stroke patients. It can serve as an effective rehabilitation therapy for neuropsychiatric sequelae of stroke.
DescriptionBronze open access
Persistent Identifierhttp://hdl.handle.net/10722/293639
ISSN
2023 Impact Factor: 5.0
2023 SCImago Journal Rankings: 1.250
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZhang, Z-
dc.contributor.authorZhao, H-
dc.contributor.authorJin, GX-
dc.contributor.authorMan, SCM-
dc.contributor.authorWang, YS-
dc.contributor.authorWang, Y-
dc.contributor.authorWang, HR-
dc.contributor.authorLi, MH-
dc.contributor.authorYam, LL-
dc.contributor.authorQIN, ZS-
dc.contributor.authorYu, KKT-
dc.contributor.authorWu, J-
dc.contributor.authorNg, FLB-
dc.contributor.authorZiea, TCE-
dc.contributor.authorRong, PJ-
dc.date.accessioned2020-11-23T08:19:40Z-
dc.date.available2020-11-23T08:19:40Z-
dc.date.issued2020-
dc.identifier.citationPsychiatry and Clinical Neurosciences, 2020, v. 74 n. 3, p. 183-190-
dc.identifier.issn1323-1316-
dc.identifier.urihttp://hdl.handle.net/10722/293639-
dc.descriptionBronze open access-
dc.description.abstractAim: Acupuncture has benefits in the rehabilitation of neuropsychiatric sequelae of stroke. This study was aimed to evaluate the effectiveness of dense cranial electroacupuncture stimulation plus body acupuncture (DCEAS+BA) in treating poststroke depression (PSD), functional disability, and cognitive deterioration. Methods: In this assessor‐ and participant‐blinded, randomized controlled trial, 91 stroke patients who initially had PSD were randomly assigned to either DCEAS+BA (n = 45) or minimum acupuncture stimulation as controls (n = 46) for three sessions per week over 8 consecutive weeks. The primary outcome was baseline‐to‐end‐point change in score of the 17‐item Hamilton Depression Rating Scale. Secondary outcomes included the Montgomery–Åsberg Depression Rating Scale for depressive symptoms, the Barthel Index for functional disability, and the Montreal Cognitive Assessment for cognitive function. Results: DCEAS+BA‐treated patients showed strikingly greater end‐point reduction than MAS‐treated patients in scores of the three symptom domains. The clinical response rate, defined as an at least 50% baseline‐to‐end‐point reduction in 17‐item Hamilton Depression Rating Scale score, was markedly higher in the DCEAS+BA‐treated group than that of controls (40.0% vs 17.4%, P = 0.031). Incidence of adverse events was not different in the two groups. Subgroup analysis revealed that DCEAS+BA with electrical stimulation on forehead acupoints was more apparent in reducing Barthel‐Index‐measured disability than that without electrical stimulation. Conclusion: DCEAS+BA, particularly with electrical stimulation on forehead acupoints, reduces PSD, functional disability, and cognitive deterioration of stroke patients. It can serve as an effective rehabilitation therapy for neuropsychiatric sequelae of stroke.-
dc.languageeng-
dc.publisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1440-1819-
dc.relation.ispartofPsychiatry and Clinical Neurosciences-
dc.rightsSubmitted (preprint) Version This is the pre-peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. Accepted (peer-reviewed) Version This is the peer reviewed version of the following article: [FULL CITE], which has been published in final form at [Link to final article using the DOI]. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.-
dc.subjectacupuncture-
dc.subjectcognitive impairment-
dc.subjectdense cranial electroacupuncture stimulation (DCEAS)-
dc.subjectfunctional disability-
dc.subjectpoststroke depression-
dc.titleAssessor‐ and participant‐blinded, randomized controlled trial of dense cranial electroacupuncture stimulation plus body acupuncture for neuropsychiatric sequelae of stroke-
dc.typeArticle-
dc.identifier.emailZhang, Z: zhangzj@hkucc.hku.hk-
dc.identifier.emailMan, SCM: marksman@hku.hk-
dc.identifier.emailYam, LL: luluyam@hku.hk-
dc.identifier.authorityZhang, Z=rp01297-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1111/pcn.12959-
dc.identifier.pmid31747095-
dc.identifier.scopuseid_2-s2.0-85076925419-
dc.identifier.hkuros319625-
dc.identifier.volume74-
dc.identifier.issue3-
dc.identifier.spage183-
dc.identifier.epage190-
dc.identifier.isiWOS:000503620400001-
dc.publisher.placeAustralia-

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