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Article: Pinosylvin provides neuroprotection against cerebral ischemia and reperfusion injury through enhancing PINK1/Parkin mediated mitophagy and Nrf2 pathway
Title | Pinosylvin provides neuroprotection against cerebral ischemia and reperfusion injury through enhancing PINK1/Parkin mediated mitophagy and Nrf2 pathway |
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Authors | |
Keywords | Cerebral ischemia Neuroprotection Pinosylvin Mitophagy Nrf2 |
Issue Date | 2020 |
Publisher | Elsevier BV. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/717426/description#description |
Citation | Journal of Functional Foods, 2020, v. 71, p. article no. 104019 How to Cite? |
Abstract | Neuroprotection is one common strategy to reduce injuries from cerebral ischemia. This study aims to evaluate neuroprotective activity of several representative stilbenes with different substituted groups to preliminarily know about their structure/activity relationship and action mechanisms. Among the stilbenes tested, only pinosylvin showed strong neuroprotective effects, evidenced by the decreased cell death in OGD/R-damaged PC12 cells and improved brain function in MCAO/R rats after pinosylvin treatment. Pinosylvin reduced the rate of depolarized cells (low mitochondrial membrane potential) in OGD/R-damaged PC12 cells, implying its role in improving mitochondrial function. Further studies indicated that pinosylvin induced PINK1/Parkin mediated protective mitophagy and activated Nrf2 pathway, suggested by the elevated protein levels of LC3 II, Beclin1, PINK1 and Parkin, and Nrf2 translocation to nucleus. In conclusion, pinosylvin exhibited neuroprotective effects by inducing PINK1/Parkin mediated mitophagy to remove damaged mitochondria and activating Nrf2 pathway to ameliorate oxidative stress-induced mitochondrial dysfunction. |
Persistent Identifier | http://hdl.handle.net/10722/293624 |
ISSN | 2023 Impact Factor: 3.8 2023 SCImago Journal Rankings: 0.900 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | XU, H | - |
dc.contributor.author | Deng, R | - |
dc.contributor.author | Li, ETS | - |
dc.contributor.author | Shen, J | - |
dc.contributor.author | Wang, M | - |
dc.date.accessioned | 2020-11-23T08:19:28Z | - |
dc.date.available | 2020-11-23T08:19:28Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Journal of Functional Foods, 2020, v. 71, p. article no. 104019 | - |
dc.identifier.issn | 1756-4646 | - |
dc.identifier.uri | http://hdl.handle.net/10722/293624 | - |
dc.description.abstract | Neuroprotection is one common strategy to reduce injuries from cerebral ischemia. This study aims to evaluate neuroprotective activity of several representative stilbenes with different substituted groups to preliminarily know about their structure/activity relationship and action mechanisms. Among the stilbenes tested, only pinosylvin showed strong neuroprotective effects, evidenced by the decreased cell death in OGD/R-damaged PC12 cells and improved brain function in MCAO/R rats after pinosylvin treatment. Pinosylvin reduced the rate of depolarized cells (low mitochondrial membrane potential) in OGD/R-damaged PC12 cells, implying its role in improving mitochondrial function. Further studies indicated that pinosylvin induced PINK1/Parkin mediated protective mitophagy and activated Nrf2 pathway, suggested by the elevated protein levels of LC3 II, Beclin1, PINK1 and Parkin, and Nrf2 translocation to nucleus. In conclusion, pinosylvin exhibited neuroprotective effects by inducing PINK1/Parkin mediated mitophagy to remove damaged mitochondria and activating Nrf2 pathway to ameliorate oxidative stress-induced mitochondrial dysfunction. | - |
dc.language | eng | - |
dc.publisher | Elsevier BV. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/717426/description#description | - |
dc.relation.ispartof | Journal of Functional Foods | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Cerebral ischemia | - |
dc.subject | Neuroprotection | - |
dc.subject | Pinosylvin | - |
dc.subject | Mitophagy | - |
dc.subject | Nrf2 | - |
dc.title | Pinosylvin provides neuroprotection against cerebral ischemia and reperfusion injury through enhancing PINK1/Parkin mediated mitophagy and Nrf2 pathway | - |
dc.type | Article | - |
dc.identifier.email | Li, ETS: etsli@hku.hk | - |
dc.identifier.email | Shen, J: shenjg@hku.hk | - |
dc.identifier.email | Wang, M: mfwang@hku.hk | - |
dc.identifier.authority | Li, ETS=rp00737 | - |
dc.identifier.authority | Shen, J=rp00487 | - |
dc.identifier.authority | Wang, M=rp00800 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1016/j.jff.2020.104019 | - |
dc.identifier.scopus | eid_2-s2.0-85085338676 | - |
dc.identifier.hkuros | 319920 | - |
dc.identifier.volume | 71 | - |
dc.identifier.spage | article no. 104019 | - |
dc.identifier.epage | article no. 104019 | - |
dc.identifier.isi | WOS:000546937800023 | - |
dc.publisher.place | Netherlands | - |
dc.identifier.issnl | 1756-4646 | - |