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Article: Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues

TitleAssessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues
Authors
KeywordsBiology
Issue 148
Endothelium
vascular smooth muscle
vasodilatation
Issue Date2019
PublisherJournal of Visualized Experiments. The Journal's web site is located at http://www.jove.com
Citation
Journal of Visualized Experiments, 2019, v. 148, p. article no. e59688 How to Cite?
AbstractAltered vascular tone responsiveness to pathophysiological stimuli contributes to the development of a wide range of cardiovascular and metabolic diseases. Endothelial dysfunction represents a major culprit for the reduced vasodilatation and enhanced vasoconstriction of arteries. Adipose (fat) tissues surrounding the arteries play important roles in the regulation of endothelium-dependent relaxation and/or contraction of the vascular smooth muscle cells. The cross-talks between the endothelium and perivascular adipose tissues can be assessed ex vivo using mounted blood vessels by a wire myography system. However, optimal settings should be established for arteries derived from animals of different species, ages, genetic backgrounds and/or pathophysiological conditions.
Persistent Identifierhttp://hdl.handle.net/10722/293533
ISSN
2023 Impact Factor: 1.2
2023 SCImago Journal Rankings: 0.449
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorKonja, D-
dc.contributor.authorLuo, C-
dc.contributor.authorSun, WY-
dc.contributor.authorYang, K-
dc.contributor.authorMan, AWC-
dc.contributor.authorXu, A-
dc.contributor.authorVanhoutte, PM-
dc.contributor.authorWang, Y-
dc.date.accessioned2020-11-23T08:18:10Z-
dc.date.available2020-11-23T08:18:10Z-
dc.date.issued2019-
dc.identifier.citationJournal of Visualized Experiments, 2019, v. 148, p. article no. e59688-
dc.identifier.issn1940-087X-
dc.identifier.urihttp://hdl.handle.net/10722/293533-
dc.description.abstractAltered vascular tone responsiveness to pathophysiological stimuli contributes to the development of a wide range of cardiovascular and metabolic diseases. Endothelial dysfunction represents a major culprit for the reduced vasodilatation and enhanced vasoconstriction of arteries. Adipose (fat) tissues surrounding the arteries play important roles in the regulation of endothelium-dependent relaxation and/or contraction of the vascular smooth muscle cells. The cross-talks between the endothelium and perivascular adipose tissues can be assessed ex vivo using mounted blood vessels by a wire myography system. However, optimal settings should be established for arteries derived from animals of different species, ages, genetic backgrounds and/or pathophysiological conditions.-
dc.languageeng-
dc.publisherJournal of Visualized Experiments. The Journal's web site is located at http://www.jove.com-
dc.relation.ispartofJournal of Visualized Experiments-
dc.rightsJournal of Visualized Experiments. Copyright © Journal of Visualized Experiments.-
dc.subjectBiology-
dc.subjectIssue 148-
dc.subjectEndothelium-
dc.subjectvascular smooth muscle-
dc.subjectvasodilatation-
dc.titleAssessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues-
dc.typeArticle-
dc.identifier.emailLuo, C: cuiting@hku.hk-
dc.identifier.emailYang, K: yangkm@hku.hk-
dc.identifier.emailXu, A: amxu@hkucc.hku.hk-
dc.identifier.emailWang, Y: yuwanghk@hku.hk-
dc.identifier.authorityXu, A=rp00485-
dc.identifier.authorityVanhoutte, PM=rp00238-
dc.identifier.authorityWang, Y=rp00239-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3791/59688-
dc.identifier.pmid31205306-
dc.identifier.scopuseid_2-s2.0-85068223677-
dc.identifier.hkuros320047-
dc.identifier.volume148-
dc.identifier.spagearticle no. e59688-
dc.identifier.epagearticle no. e59688-
dc.identifier.isiWOS:000473295900083-
dc.publisher.placeUnited States-

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