File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Adrenomedullin insufficiency alters macrophage activities in fallopian tube: a pathophysiologic explanation of tubal ectopic pregnancy

TitleAdrenomedullin insufficiency alters macrophage activities in fallopian tube: a pathophysiologic explanation of tubal ectopic pregnancy
Authors
Issue Date2020
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/mi/index.html
Citation
Mucosal Immunology, 2020, v. 13, p. 743-752 How to Cite?
AbstractEctopic pregnancy is the major cause of maternal morbidity and mortality in the first trimester of pregnancy. Tubal ectopic pregnancy (TEP) accounts for nearly 98% of all ectopic pregnancies. TEP is usually associated with salpingitis but the underlying mechanism in salpingitis leading to TEP remains unclear. Adrenomedullin (ADM) is a peptide hormone abundantly expressed in the fallopian tube with potent anti-inflammatory activities. Its expression peaks at the early luteal phase when the developing embryo is being transported through the fallopian tube. In the present study, we demonstrated reduced expression of ADM in fallopian tubes of patients with salpingitis and TEP. Using macrophages isolated from the fallopian tubes of these women, our data revealed that the salpingistis-associated ADM reduction contributed to aggravated pro-inflammatory responses of the tubal macrophages resulting in production of pro-inflammatory and pro-implantation cytokines IL-6 and IL-8. These cytokines activated the expression of implantation-associated molecules and Wnt signaling pathway predisposing the tubal epithelium to an adhesive and receptive state for embryo implantation. In conclusion, this study provided evidence for the role of ADM in the pathogenesis of TEP through regulating the functions of tubal macrophages.
Persistent Identifierhttp://hdl.handle.net/10722/293450
ISSN
2023 Impact Factor: 7.9
2023 SCImago Journal Rankings: 3.320
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWang, X-
dc.contributor.authorLee, CL-
dc.contributor.authorVIJAYAN, M-
dc.contributor.authorYeung, WSB-
dc.contributor.authorNg, EHY-
dc.contributor.authorWang, X-
dc.contributor.authorO, WS-
dc.contributor.authorLi, RHW-
dc.contributor.authorZhang, Y-
dc.contributor.authorChiu, PCN-
dc.date.accessioned2020-11-23T08:16:56Z-
dc.date.available2020-11-23T08:16:56Z-
dc.date.issued2020-
dc.identifier.citationMucosal Immunology, 2020, v. 13, p. 743-752-
dc.identifier.issn1933-0219-
dc.identifier.urihttp://hdl.handle.net/10722/293450-
dc.description.abstractEctopic pregnancy is the major cause of maternal morbidity and mortality in the first trimester of pregnancy. Tubal ectopic pregnancy (TEP) accounts for nearly 98% of all ectopic pregnancies. TEP is usually associated with salpingitis but the underlying mechanism in salpingitis leading to TEP remains unclear. Adrenomedullin (ADM) is a peptide hormone abundantly expressed in the fallopian tube with potent anti-inflammatory activities. Its expression peaks at the early luteal phase when the developing embryo is being transported through the fallopian tube. In the present study, we demonstrated reduced expression of ADM in fallopian tubes of patients with salpingitis and TEP. Using macrophages isolated from the fallopian tubes of these women, our data revealed that the salpingistis-associated ADM reduction contributed to aggravated pro-inflammatory responses of the tubal macrophages resulting in production of pro-inflammatory and pro-implantation cytokines IL-6 and IL-8. These cytokines activated the expression of implantation-associated molecules and Wnt signaling pathway predisposing the tubal epithelium to an adhesive and receptive state for embryo implantation. In conclusion, this study provided evidence for the role of ADM in the pathogenesis of TEP through regulating the functions of tubal macrophages.-
dc.languageeng-
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/mi/index.html-
dc.relation.ispartofMucosal Immunology-
dc.titleAdrenomedullin insufficiency alters macrophage activities in fallopian tube: a pathophysiologic explanation of tubal ectopic pregnancy-
dc.typeArticle-
dc.identifier.emailLee, CL: kcllee@hku.hk-
dc.identifier.emailYeung, WSB: wsbyeung@hku.hk-
dc.identifier.emailNg, EHY: nghye@hku.hk-
dc.identifier.emailLi, RHW: raymondli@hku.hk-
dc.identifier.emailChiu, PCN: pchiucn@hku.hk-
dc.identifier.authorityLee, CL=rp02515-
dc.identifier.authorityYeung, WSB=rp00331-
dc.identifier.authorityNg, EHY=rp00426-
dc.identifier.authorityO, WS=rp00315-
dc.identifier.authorityLi, RHW=rp01649-
dc.identifier.authorityChiu, PCN=rp00424-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/s41385-020-0278-6-
dc.identifier.pmid32203061-
dc.identifier.scopuseid_2-s2.0-85081886712-
dc.identifier.hkuros319474-
dc.identifier.volume13-
dc.identifier.spage743-
dc.identifier.epage752-
dc.identifier.isiWOS:000519422700002-
dc.publisher.placeUnited States-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats