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Article: Emergence of Staphylococcus lugdunensis as a Cause of Urinary Tract Infection: Results of the Routine Use of MALDI-TOF MS

TitleEmergence of Staphylococcus lugdunensis as a Cause of Urinary Tract Infection: Results of the Routine Use of MALDI-TOF MS
Authors
KeywordsStaphylococcus lugdunensis
urinary tract infection
MALDI-TOF MS
Issue Date2020
PublisherMDPI AG. The Journal's web site is located at http://www.mdpi.com/journal/microorganisms
Citation
Microorganisms, 2020, v. 8 n. 3, p. article no. 381 How to Cite?
AbstractWe analyzed the incidence and the clinical and laboratory characteristics of Staphylococcus lugdunensis urinary tract infections (UTIs) during a 10-year period (2009–2018) and compared them with those of Staphylococcus saprophyticus UTIs. A total of 38 and 162 episodes of S. lugdunensis and S. saprophyticus UTIs were observed. The number of S. saprophyticus UTIs was stable throughout the 10 years, whereas there was an obvious surge in the apparent number of S. lugdunensis UTIs since 2014, coinciding with the commencement of a routine use of MALDI-TOF MS. Univariate analysis showed that male sex (p < 0.001), advanced age (p < 0.001), hospital-acquired infections, (p < 0.001), upper UTI (p < 0.005), polymicrobial infections (p < 0.05), hypertension (p < 0.001), solid-organ malignancies (p < 0.001), renal stones (p < 0.001), urinary stricture (p < 0.05), vesicoureteral reflux (p < 0.001), and presence of a urinary catheter (p < 0.001) were significantly associated with S. lugdunensis UTI. Multivariable analysis revealed that S. lugdunensis UTI was associated with male sex (OR = 6.08, p < 0.05), solid-organ malignancies (OR = 12.27, p < 0.01), and urological system abnormalities (OR = 7.44, p < 0.05). There were significant differences in the patient population affected and predisposing factors between S. lugdunensis and S. saprophyticus UTIs.
Persistent Identifierhttp://hdl.handle.net/10722/293403
ISSN
2023 Impact Factor: 4.1
2023 SCImago Journal Rankings: 0.944
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChiu, KHY-
dc.contributor.authorLam, RPK-
dc.contributor.authorChan, E-
dc.contributor.authorLau, SKP-
dc.contributor.authorWoo, PCY-
dc.date.accessioned2020-11-23T08:16:15Z-
dc.date.available2020-11-23T08:16:15Z-
dc.date.issued2020-
dc.identifier.citationMicroorganisms, 2020, v. 8 n. 3, p. article no. 381-
dc.identifier.issn2076-2607-
dc.identifier.urihttp://hdl.handle.net/10722/293403-
dc.description.abstractWe analyzed the incidence and the clinical and laboratory characteristics of Staphylococcus lugdunensis urinary tract infections (UTIs) during a 10-year period (2009–2018) and compared them with those of Staphylococcus saprophyticus UTIs. A total of 38 and 162 episodes of S. lugdunensis and S. saprophyticus UTIs were observed. The number of S. saprophyticus UTIs was stable throughout the 10 years, whereas there was an obvious surge in the apparent number of S. lugdunensis UTIs since 2014, coinciding with the commencement of a routine use of MALDI-TOF MS. Univariate analysis showed that male sex (p < 0.001), advanced age (p < 0.001), hospital-acquired infections, (p < 0.001), upper UTI (p < 0.005), polymicrobial infections (p < 0.05), hypertension (p < 0.001), solid-organ malignancies (p < 0.001), renal stones (p < 0.001), urinary stricture (p < 0.05), vesicoureteral reflux (p < 0.001), and presence of a urinary catheter (p < 0.001) were significantly associated with S. lugdunensis UTI. Multivariable analysis revealed that S. lugdunensis UTI was associated with male sex (OR = 6.08, p < 0.05), solid-organ malignancies (OR = 12.27, p < 0.01), and urological system abnormalities (OR = 7.44, p < 0.05). There were significant differences in the patient population affected and predisposing factors between S. lugdunensis and S. saprophyticus UTIs.-
dc.languageeng-
dc.publisherMDPI AG. The Journal's web site is located at http://www.mdpi.com/journal/microorganisms-
dc.relation.ispartofMicroorganisms-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectStaphylococcus lugdunensis-
dc.subjecturinary tract infection-
dc.subjectMALDI-TOF MS-
dc.titleEmergence of Staphylococcus lugdunensis as a Cause of Urinary Tract Infection: Results of the Routine Use of MALDI-TOF MS-
dc.typeArticle-
dc.identifier.emailChiu, KHY: hychiu14@hku.hk-
dc.identifier.emailLam, RPK: lampkrex@hku.hk-
dc.identifier.emailChan, E: echan206@hku.hk-
dc.identifier.emailLau, SKP: skplau@hkucc.hku.hk-
dc.identifier.emailWoo, PCY: pcywoo@hkucc.hku.hk-
dc.identifier.authorityLam, RPK=rp02015-
dc.identifier.authorityLau, SKP=rp00486-
dc.identifier.authorityWoo, PCY=rp00430-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3390/microorganisms8030381-
dc.identifier.pmid32182757-
dc.identifier.pmcidPMC7143294-
dc.identifier.scopuseid_2-s2.0-85081604976-
dc.identifier.hkuros319730-
dc.identifier.volume8-
dc.identifier.issue3-
dc.identifier.spagearticle no. 381-
dc.identifier.epagearticle no. 381-
dc.identifier.isiWOS:000525952700069-
dc.publisher.placeSwitzerland-

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