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Article: Association between Adipocyte Fatty Acid-Binding Protein with Left Ventricular Remodelling and Diastolic Function in Type 2 Diabetes: A Prospective Echocardiography Study

TitleAssociation between Adipocyte Fatty Acid-Binding Protein with Left Ventricular Remodelling and Diastolic Function in Type 2 Diabetes: A Prospective Echocardiography Study
Authors
KeywordsAFABP
Echocardiography
Major adverse cardiovascular events
Type 2 diabetes
Issue Date2020
PublisherBioMed Central Ltd. The Journal's web site is located at http://www.cardiab.com/
Citation
Cardiovascular Diabetology, 2020, v. 19, p. article no. 197 How to Cite?
AbstractBackground: The relationship between adipocyte fatty acid-binding protein (AFABP) and cardiac remodelling has been reported in cross-sectional studies, although with conflicting results. Type 2 diabetes mellitus (T2DM) is associated with left ventricular (LV) hypertrophy and diastolic dysfunction, as well as elevated circulating AFABP levels. Here we investigated prospectively the association between AFABP with the longitudinal changes of cardiac remodelling and diastolic dysfunction in T2DM. Methods: Circulating AFABP levels were measured in 176 T2DM patients without cardiovascular diseases (CVD) at baseline. All participants received detailed transthoracic echocardiography both at baseline and after 1 year. Multivariable linear and Cox regression analyses were used to evaluate the associations of circulating AFABP levels with changes in echocardiography parameters and incident major adverse cardiovascular events (MACE), respectively. Results: The median duration between baseline and follow-up echocardiography assessments was 28 months. Higher sex-specific AFABP quartiles at baseline were associated with increase in LV mass and worsening of average E/e′ (all P < 0.01). Multivariable linear regression demonstrated that AFABP in the highest quartile was independently associated with both increase in LV mass (β = 0.89, P < 0.01) and worsening of average E/e′ (β = 0.57, P < 0.05). Moreover, multivariable Cox regression analysis showed that elevated baseline circulating AFABP level independently predicted incident MACE (HR 2.65, 95% CI 1.16–6.05, P < 0.05) after adjustments for age, sex, body mass index, glycated haemoglobin, hypertension, dyslipidemia and presence of chronic kidney disease. Conclusion: Circulating AFABP level at baseline predicted the development of LV hypertrophy, diastolic dysfunction and MACE in T2DM patients without CVD.
Persistent Identifierhttp://hdl.handle.net/10722/293395
ISSN
2018 Impact Factor: 5.948
2015 SCImago Journal Rankings: 1.757
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWu, MZ-
dc.contributor.authorLee, CH-
dc.contributor.authorChen, Y-
dc.contributor.authorYu, SY-
dc.contributor.authorYU, YJ-
dc.contributor.authorRen, QW-
dc.contributor.authorFong, HY-
dc.contributor.authorWong, PF-
dc.contributor.authorTse, HF-
dc.contributor.authorLam, SLK-
dc.contributor.authorYiu, KH-
dc.date.accessioned2020-11-23T08:16:08Z-
dc.date.available2020-11-23T08:16:08Z-
dc.date.issued2020-
dc.identifier.citationCardiovascular Diabetology, 2020, v. 19, p. article no. 197-
dc.identifier.issn1475-2840-
dc.identifier.urihttp://hdl.handle.net/10722/293395-
dc.description.abstractBackground: The relationship between adipocyte fatty acid-binding protein (AFABP) and cardiac remodelling has been reported in cross-sectional studies, although with conflicting results. Type 2 diabetes mellitus (T2DM) is associated with left ventricular (LV) hypertrophy and diastolic dysfunction, as well as elevated circulating AFABP levels. Here we investigated prospectively the association between AFABP with the longitudinal changes of cardiac remodelling and diastolic dysfunction in T2DM. Methods: Circulating AFABP levels were measured in 176 T2DM patients without cardiovascular diseases (CVD) at baseline. All participants received detailed transthoracic echocardiography both at baseline and after 1 year. Multivariable linear and Cox regression analyses were used to evaluate the associations of circulating AFABP levels with changes in echocardiography parameters and incident major adverse cardiovascular events (MACE), respectively. Results: The median duration between baseline and follow-up echocardiography assessments was 28 months. Higher sex-specific AFABP quartiles at baseline were associated with increase in LV mass and worsening of average E/e′ (all P < 0.01). Multivariable linear regression demonstrated that AFABP in the highest quartile was independently associated with both increase in LV mass (β = 0.89, P < 0.01) and worsening of average E/e′ (β = 0.57, P < 0.05). Moreover, multivariable Cox regression analysis showed that elevated baseline circulating AFABP level independently predicted incident MACE (HR 2.65, 95% CI 1.16–6.05, P < 0.05) after adjustments for age, sex, body mass index, glycated haemoglobin, hypertension, dyslipidemia and presence of chronic kidney disease. Conclusion: Circulating AFABP level at baseline predicted the development of LV hypertrophy, diastolic dysfunction and MACE in T2DM patients without CVD.-
dc.languageeng-
dc.publisherBioMed Central Ltd. The Journal's web site is located at http://www.cardiab.com/-
dc.relation.ispartofCardiovascular Diabetology-
dc.rightsCardiovascular Diabetology. Copyright © BioMed Central Ltd.-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectAFABP-
dc.subjectEchocardiography-
dc.subjectMajor adverse cardiovascular events-
dc.subjectType 2 diabetes-
dc.titleAssociation between Adipocyte Fatty Acid-Binding Protein with Left Ventricular Remodelling and Diastolic Function in Type 2 Diabetes: A Prospective Echocardiography Study-
dc.typeArticle-
dc.identifier.emailLee, CH: pchlee@hku.hk-
dc.identifier.emailYu, SY: angelysy@hku.hk-
dc.identifier.emailRen, QW: angela93@HKUCC-COM.hku.hk-
dc.identifier.emailFong, HY: kalofong@hku.hk-
dc.identifier.emailWong, PF: wongpf@hku.hk-
dc.identifier.emailTse, HF: hftse@hkucc.hku.hk-
dc.identifier.emailLam, SLK: ksllam@hku.hk-
dc.identifier.emailYiu, KH: khkyiu@hku.hk-
dc.identifier.authorityLee, CH=rp02043-
dc.identifier.authorityTse, HF=rp00428-
dc.identifier.authorityLam, SLK=rp00343-
dc.identifier.authorityYiu, KH=rp01490-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1186/s12933-020-01167-5-
dc.identifier.pmid33234149-
dc.identifier.pmcidPMC7687743-
dc.identifier.scopuseid_2-s2.0-85096625651-
dc.identifier.hkuros320091-
dc.identifier.volume19-
dc.identifier.spagearticle no. 197-
dc.identifier.epagearticle no. 197-
dc.identifier.isiWOS:000595748500001-
dc.publisher.placeUnited Kingdom-
dc.identifier.issnl1475-2840-

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