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Article: Aromatic compounds lead to increased abundance of antibiotic resistance genes in wastewater treatment bioreactors

TitleAromatic compounds lead to increased abundance of antibiotic resistance genes in wastewater treatment bioreactors
Authors
KeywordsAntibiotic resistance
Aromatic degradation
Wastewater treatment
Activated sludge
Metagenomics
Issue Date2019
PublisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/watres
Citation
Water Research, 2019, v. 166, p. article no. 115073 How to Cite?
AbstractVarious aromatic compounds in wastewater, especially industrial wastewater, are treated by biological processes in bioreactors which are regarded as hotspots and reservoirs of antibiotic resistance genes (ARGs). Yet, little is known about the relationship between the aromatic compound degradation process and antibiotic resistance. Here, we report on the co-occurrence of ARGs and aromatic degradation genes (ADGs) in bacteria in bioreactors. We confirmed this by bioreactor experiments and bioinformatics analysis of over 10,000 publicly available bacterial genomes. We observed a significant enrichment of ARGs in bioreactors treating wastewater that contained p-aminophenol and p-nitrophenol. The potential hosts harboring ARGs and ADGs were mainly Pseudomonas, Leucobacter, Xanthobacter, Acinetobacter, and Burkholderiaceae. Genome analysis revealed that 67.6% of the publicly available bacterial genomes harboring ADGs also harbor ARGs. Over 80% of Burkholderiales, Xanthomonales, Enterobacteriaceae, Acinetobacter, Pseudomonas, and Nocardiaceae genomes harbor both ARGs and ADGs, which strongly suggests the co-occurrence of these genes. Furthermore, bacteria carrying ADGs harbored more than twice the number of ARGs than bacteria only carrying ARGs. Network analysis suggested that multidrug, beta-lactam, aminoglycoside, macrolide-lincosamide-streptogramin, and polymyxin resistance genes are the major ARGs associated with ADGs. Taken together, the presented findings improve the understanding of ARG prevalence in biological wastewater treatment plants, and highlight the potential risk of the effect of regular aromatic compounds on the selection and spread of ARGs.
Persistent Identifierhttp://hdl.handle.net/10722/293312
ISSN
2023 Impact Factor: 11.4
2023 SCImago Journal Rankings: 3.596
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorXia, J-
dc.contributor.authorSun, H-
dc.contributor.authorZhang, XX-
dc.contributor.authorZhang, T-
dc.contributor.authorRen, H-
dc.contributor.authorYe, L-
dc.date.accessioned2020-11-23T08:14:56Z-
dc.date.available2020-11-23T08:14:56Z-
dc.date.issued2019-
dc.identifier.citationWater Research, 2019, v. 166, p. article no. 115073-
dc.identifier.issn0043-1354-
dc.identifier.urihttp://hdl.handle.net/10722/293312-
dc.description.abstractVarious aromatic compounds in wastewater, especially industrial wastewater, are treated by biological processes in bioreactors which are regarded as hotspots and reservoirs of antibiotic resistance genes (ARGs). Yet, little is known about the relationship between the aromatic compound degradation process and antibiotic resistance. Here, we report on the co-occurrence of ARGs and aromatic degradation genes (ADGs) in bacteria in bioreactors. We confirmed this by bioreactor experiments and bioinformatics analysis of over 10,000 publicly available bacterial genomes. We observed a significant enrichment of ARGs in bioreactors treating wastewater that contained p-aminophenol and p-nitrophenol. The potential hosts harboring ARGs and ADGs were mainly Pseudomonas, Leucobacter, Xanthobacter, Acinetobacter, and Burkholderiaceae. Genome analysis revealed that 67.6% of the publicly available bacterial genomes harboring ADGs also harbor ARGs. Over 80% of Burkholderiales, Xanthomonales, Enterobacteriaceae, Acinetobacter, Pseudomonas, and Nocardiaceae genomes harbor both ARGs and ADGs, which strongly suggests the co-occurrence of these genes. Furthermore, bacteria carrying ADGs harbored more than twice the number of ARGs than bacteria only carrying ARGs. Network analysis suggested that multidrug, beta-lactam, aminoglycoside, macrolide-lincosamide-streptogramin, and polymyxin resistance genes are the major ARGs associated with ADGs. Taken together, the presented findings improve the understanding of ARG prevalence in biological wastewater treatment plants, and highlight the potential risk of the effect of regular aromatic compounds on the selection and spread of ARGs.-
dc.languageeng-
dc.publisherPergamon. The Journal's web site is located at http://www.elsevier.com/locate/watres-
dc.relation.ispartofWater Research-
dc.subjectAntibiotic resistance-
dc.subjectAromatic degradation-
dc.subjectWastewater treatment-
dc.subjectActivated sludge-
dc.subjectMetagenomics-
dc.titleAromatic compounds lead to increased abundance of antibiotic resistance genes in wastewater treatment bioreactors-
dc.typeArticle-
dc.identifier.emailZhang, T: zhangt@hkucc.hku.hk-
dc.identifier.authorityZhang, T=rp00211-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.watres.2019.115073-
dc.identifier.pmid31542545-
dc.identifier.scopuseid_2-s2.0-85072280297-
dc.identifier.hkuros319439-
dc.identifier.volume166-
dc.identifier.spagearticle no. 115073-
dc.identifier.epagearticle no. 115073-
dc.identifier.isiWOS:000493221600049-
dc.publisher.placeUnited Kingdom-
dc.identifier.issnl0043-1354-

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