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- Publisher Website: 10.1039/C9CC07605K
- Scopus: eid_2-s2.0-85074245700
- PMID: 31616884
- WOS: WOS:000494428800013
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Article: S-Dimethylarsino-glutathione (darinaparsin®) targets histone H3.3, leading to TRAIL-induced apoptosis in leukemia cells
Title | S-Dimethylarsino-glutathione (darinaparsin®) targets histone H3.3, leading to TRAIL-induced apoptosis in leukemia cells |
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Authors | |
Keywords | apoptosis clinical effectiveness controlled study cytotoxicity drug effect |
Issue Date | 2019 |
Publisher | Royal Society of Chemistry. The Journal's web site is located at http://www.rsc.org/Publishing/Journals/cc/index.asp |
Citation | Chemical Communications, 2019, v. 55 n. 87, p. 13120-13123 How to Cite? |
Abstract | Histone H3.3 was identified as an arsenic-binding protein of S-dimethylarsino-glutathione (ZIO-101, darinaparsin®) in leukemia cells by GE-ICP-MS. Such a binding results in TRAIL-induced apoptosis. We further validate histone H3.3 as a vital target for ZIO-101, offering new information on the mode of action of arsenic-based anticancer agents. |
Persistent Identifier | http://hdl.handle.net/10722/293268 |
ISSN | 2023 Impact Factor: 4.3 2023 SCImago Journal Rankings: 1.133 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Xu, X | - |
dc.contributor.author | Wang, H | - |
dc.contributor.author | Li, H | - |
dc.contributor.author | Hu, X | - |
dc.contributor.author | Zhang, Y | - |
dc.contributor.author | Guan, X | - |
dc.contributor.author | Toy, PH | - |
dc.contributor.author | Sun, H | - |
dc.date.accessioned | 2020-11-23T08:14:16Z | - |
dc.date.available | 2020-11-23T08:14:16Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Chemical Communications, 2019, v. 55 n. 87, p. 13120-13123 | - |
dc.identifier.issn | 1359-7345 | - |
dc.identifier.uri | http://hdl.handle.net/10722/293268 | - |
dc.description.abstract | Histone H3.3 was identified as an arsenic-binding protein of S-dimethylarsino-glutathione (ZIO-101, darinaparsin®) in leukemia cells by GE-ICP-MS. Such a binding results in TRAIL-induced apoptosis. We further validate histone H3.3 as a vital target for ZIO-101, offering new information on the mode of action of arsenic-based anticancer agents. | - |
dc.language | eng | - |
dc.publisher | Royal Society of Chemistry. The Journal's web site is located at http://www.rsc.org/Publishing/Journals/cc/index.asp | - |
dc.relation.ispartof | Chemical Communications | - |
dc.subject | apoptosis | - |
dc.subject | clinical effectiveness | - |
dc.subject | controlled study | - |
dc.subject | cytotoxicity | - |
dc.subject | drug effect | - |
dc.title | S-Dimethylarsino-glutathione (darinaparsin®) targets histone H3.3, leading to TRAIL-induced apoptosis in leukemia cells | - |
dc.type | Article | - |
dc.identifier.email | Wang, H: wanghaib@hku.hk | - |
dc.identifier.email | Li, H: hylichem@hku.hk | - |
dc.identifier.email | Guan, X: xyguan@hku.hk | - |
dc.identifier.email | Toy, PH: phtoy@hkucc.hku.hk | - |
dc.identifier.email | Sun, H: hsun@hku.hk | - |
dc.identifier.authority | Guan, X=rp00454 | - |
dc.identifier.authority | Toy, PH=rp00791 | - |
dc.identifier.authority | Sun, H=rp00777 | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1039/C9CC07605K | - |
dc.identifier.pmid | 31616884 | - |
dc.identifier.scopus | eid_2-s2.0-85074245700 | - |
dc.identifier.hkuros | 319808 | - |
dc.identifier.volume | 55 | - |
dc.identifier.issue | 87 | - |
dc.identifier.spage | 13120 | - |
dc.identifier.epage | 13123 | - |
dc.identifier.isi | WOS:000494428800013 | - |
dc.publisher.place | United Kingdom | - |
dc.identifier.issnl | 1359-7345 | - |