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Article: Monoamine oxidase A is down-regulated in EBV-associated nasopharyngeal carcinoma

TitleMonoamine oxidase A is down-regulated in EBV-associated nasopharyngeal carcinoma
Authors
Issue Date2020
PublisherNature Research: Fully open access journals. The Journal's web site is located at http://www.nature.com/srep/index.html
Citation
Scientific Reports, 2020, v. 10, p. article no. 6115 How to Cite?
AbstractNasopharyngeal carcinoma (NPC) is a highly metastatic cancer that is consistently associated with Epstein-Barr virus (EBV) infection. In this study, we identify for the first time a role for monoamine oxidase A (MAOA) in NPC. MAOA is a mitochondrial enzyme that catalyzes oxidative deamination of neurotransmitters and dietary amines. Depending on the cancer type, MAOA can either have a tumour-promoting or tumour-suppressive role. We show that MAOA is down-regulated in primary NPC tissues and its down-regulation enhances the migration of NPC cells. In addition, we found that EBV infection can down-regulate MAOA expression in both pre-malignant and malignant nasopharyngeal epithelial (NPE) cells. We further demonstrate that MAOA is down-regulated as a result of IL-6/IL-6R/STAT3 signalling and epigenetic mechanisms, effects that might be attributed to EBV infection in NPE cells. Taken together, our data point to a central role for EBV in mediating the tumour suppressive effects of MAOA and that loss of MAOA could be an important step in the pathogenesis of NPC.
Persistent Identifierhttp://hdl.handle.net/10722/293219
ISSN
2023 Impact Factor: 3.8
2023 SCImago Journal Rankings: 0.900
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLee, HM-
dc.contributor.authorSia, APE-
dc.contributor.authorLi, L-
dc.contributor.authorSathasivam, HP-
dc.contributor.authorChan, MSA-
dc.contributor.authorRajadurai, P-
dc.contributor.authorTsang, CM-
dc.contributor.authorTsao, SW-
dc.contributor.authorMurray, PG-
dc.contributor.authorTao, Q-
dc.contributor.authorPaterson, IC-
dc.contributor.authorYap, LF-
dc.date.accessioned2020-11-23T08:13:33Z-
dc.date.available2020-11-23T08:13:33Z-
dc.date.issued2020-
dc.identifier.citationScientific Reports, 2020, v. 10, p. article no. 6115-
dc.identifier.issn2045-2322-
dc.identifier.urihttp://hdl.handle.net/10722/293219-
dc.description.abstractNasopharyngeal carcinoma (NPC) is a highly metastatic cancer that is consistently associated with Epstein-Barr virus (EBV) infection. In this study, we identify for the first time a role for monoamine oxidase A (MAOA) in NPC. MAOA is a mitochondrial enzyme that catalyzes oxidative deamination of neurotransmitters and dietary amines. Depending on the cancer type, MAOA can either have a tumour-promoting or tumour-suppressive role. We show that MAOA is down-regulated in primary NPC tissues and its down-regulation enhances the migration of NPC cells. In addition, we found that EBV infection can down-regulate MAOA expression in both pre-malignant and malignant nasopharyngeal epithelial (NPE) cells. We further demonstrate that MAOA is down-regulated as a result of IL-6/IL-6R/STAT3 signalling and epigenetic mechanisms, effects that might be attributed to EBV infection in NPE cells. Taken together, our data point to a central role for EBV in mediating the tumour suppressive effects of MAOA and that loss of MAOA could be an important step in the pathogenesis of NPC.-
dc.languageeng-
dc.publisherNature Research: Fully open access journals. The Journal's web site is located at http://www.nature.com/srep/index.html-
dc.relation.ispartofScientific Reports-
dc.rightsScientific Reports. Copyright © Nature Research: Fully open access journals.-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleMonoamine oxidase A is down-regulated in EBV-associated nasopharyngeal carcinoma-
dc.typeArticle-
dc.identifier.emailTsang, CM: annatsan@hku.hk-
dc.identifier.emailTsao, SW: gswtsao@hku.hk-
dc.identifier.authorityTsang, CM=rp01964-
dc.identifier.authorityTsao, SW=rp00399-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1038/s41598-020-63150-0-
dc.identifier.pmid32273550-
dc.identifier.pmcidPMC7145851-
dc.identifier.scopuseid_2-s2.0-85083059047-
dc.identifier.hkuros319428-
dc.identifier.volume10-
dc.identifier.spagearticle no. 6115-
dc.identifier.epagearticle no. 6115-
dc.identifier.isiWOS:000528012000008-
dc.publisher.placeUnited Kingdom-

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