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Article: TRPM8 channels: A review of distribution and clinical role

TitleTRPM8 channels: A review of distribution and clinical role
Authors
KeywordsPathophysiology
TRPM8
Neuropathic pain
Ion channels
Bladder disorders
Prostate cancer
Issue Date2020
Citation
European Journal of Pharmacology, 2020, v. 882, article no. 173312 How to Cite?
Abstract© 2020 Elsevier B.V. Ion channels are important therapeutic targets due to their plethoric involvement in physiological and pathological consequences. The transient receptor potential cation channel subfamily M member 8 (TRPM8) is a nonselective cation channel that controls Ca2+ homeostasis. It has been proposed to be the predominant thermoreceptor for cellular and behavioral responses to cold stimuli in the transient receptor potential (TRP) channel subfamilies and exploited so far to reach the clinical-stage of drug development. TRPM8 channels can be found in multiple organs and tissues, regulating several important processes such as cell proliferation, migration and apoptosis, inflammatory reactions, immunomodulatory effects, pain, and vascular muscle tension. The related disorders have been expanded to new fields ranging from cancer and migraine to dry eye disease, pruritus, irritable bowel syndrome (IBS), and chronic cough. This review is aimed to summarize the distribution of TRPM8 and disorders related to it from a clinical perspective, so as to broaden the scope of knowledge of researchers to conduct more studies on this subject.
Persistent Identifierhttp://hdl.handle.net/10722/293132
ISSN
2023 Impact Factor: 4.2
2023 SCImago Journal Rankings: 1.055
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLiu, Yuqian-
dc.contributor.authorMikrani, Reyaj-
dc.contributor.authorHe, Yanjun-
dc.contributor.authorBaig, Mirza Muhammad Faran Ashraf-
dc.contributor.authorAbbas, Muhammad-
dc.contributor.authorNaveed, Muhammad-
dc.contributor.authorTang, Meng-
dc.contributor.authorZhang, Qin-
dc.contributor.authorLi, Cuican-
dc.contributor.authorZhou, Xiaohui-
dc.date.accessioned2020-11-19T09:02:03Z-
dc.date.available2020-11-19T09:02:03Z-
dc.date.issued2020-
dc.identifier.citationEuropean Journal of Pharmacology, 2020, v. 882, article no. 173312-
dc.identifier.issn0014-2999-
dc.identifier.urihttp://hdl.handle.net/10722/293132-
dc.description.abstract© 2020 Elsevier B.V. Ion channels are important therapeutic targets due to their plethoric involvement in physiological and pathological consequences. The transient receptor potential cation channel subfamily M member 8 (TRPM8) is a nonselective cation channel that controls Ca2+ homeostasis. It has been proposed to be the predominant thermoreceptor for cellular and behavioral responses to cold stimuli in the transient receptor potential (TRP) channel subfamilies and exploited so far to reach the clinical-stage of drug development. TRPM8 channels can be found in multiple organs and tissues, regulating several important processes such as cell proliferation, migration and apoptosis, inflammatory reactions, immunomodulatory effects, pain, and vascular muscle tension. The related disorders have been expanded to new fields ranging from cancer and migraine to dry eye disease, pruritus, irritable bowel syndrome (IBS), and chronic cough. This review is aimed to summarize the distribution of TRPM8 and disorders related to it from a clinical perspective, so as to broaden the scope of knowledge of researchers to conduct more studies on this subject.-
dc.languageeng-
dc.relation.ispartofEuropean Journal of Pharmacology-
dc.subjectPathophysiology-
dc.subjectTRPM8-
dc.subjectNeuropathic pain-
dc.subjectIon channels-
dc.subjectBladder disorders-
dc.subjectProstate cancer-
dc.titleTRPM8 channels: A review of distribution and clinical role-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.ejphar.2020.173312-
dc.identifier.pmid32610057-
dc.identifier.scopuseid_2-s2.0-85087391632-
dc.identifier.hkuros320909-
dc.identifier.volume882-
dc.identifier.spagearticle no. 173312-
dc.identifier.epagearticle no. 173312-
dc.identifier.eissn1879-0712-
dc.identifier.isiWOS:000560663000010-
dc.identifier.issnl0014-2999-

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