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- Publisher Website: 10.1021/acs.nanolett.9b03325
- Scopus: eid_2-s2.0-85073073099
- PMID: 31515999
- WOS: WOS:000490353500101
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Article: A DNA Nanodevice Simultaneously Activating the EGFR and Integrin for Enhancing Cytoskeletal Activity and Cancer Cell Treatment
Title | A DNA Nanodevice Simultaneously Activating the EGFR and Integrin for Enhancing Cytoskeletal Activity and Cancer Cell Treatment |
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Authors | |
Keywords | pN forces DNA nanodevice (DNA-ND) caveolae Cell surface receptors EGFR and integrin cytoskeleton |
Issue Date | 2019 |
Citation | Nano Letters, 2019, v. 19, n. 10, p. 7503-7513 How to Cite? |
Abstract | © 2019 American Chemical Society. Cell-surface receptors (e.g., EGFR and integrin) and their interactions play determining roles in signal transduction and cytoskeletal activation, which affect cell attachment/detachment, invasion, motility, metastasis (intracellular), and cell-cell signaling. For instance, the interactions between the EGFR and integrin (α6β4) may cause increased mechanical force and shear stress via enhanced cytoskeleton activation. Here, we design a DNA nanodevice (DNA-ND) that can simultaneously target the EGFR and integrin receptors on the caveolae. The piconewton (pN) forces in response to the EGFR-integrin coactivation can be sensed upon the unfolding of the DNA hairpin structure on the side arm of the device via changes of the fluorescence and plasmonic signals. We find that simultaneous activation of EGFR-integrin receptors causes enhanced signal transduction, contractions of the cells, and initiation of the biochemical pathways, thus resulting in a change of the cell division and endocytosis/exocytosis processes that affect the cell proliferation/apoptosis. The DNA-ND further enables us to visualize the cointernalization and degradation of the receptors by lysosomes, providing a novel approach toward bioimaging and mechano-pharmacology. |
Persistent Identifier | http://hdl.handle.net/10722/293120 |
ISSN | 2023 Impact Factor: 9.6 2023 SCImago Journal Rankings: 3.411 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Baig, Mirza Muhammad Faran Ashraf | - |
dc.contributor.author | Zhang, Qian Wen | - |
dc.contributor.author | Younis, Muhammad Rizwan | - |
dc.contributor.author | Xia, Xing Hua | - |
dc.date.accessioned | 2020-11-19T09:02:01Z | - |
dc.date.available | 2020-11-19T09:02:01Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Nano Letters, 2019, v. 19, n. 10, p. 7503-7513 | - |
dc.identifier.issn | 1530-6984 | - |
dc.identifier.uri | http://hdl.handle.net/10722/293120 | - |
dc.description.abstract | © 2019 American Chemical Society. Cell-surface receptors (e.g., EGFR and integrin) and their interactions play determining roles in signal transduction and cytoskeletal activation, which affect cell attachment/detachment, invasion, motility, metastasis (intracellular), and cell-cell signaling. For instance, the interactions between the EGFR and integrin (α6β4) may cause increased mechanical force and shear stress via enhanced cytoskeleton activation. Here, we design a DNA nanodevice (DNA-ND) that can simultaneously target the EGFR and integrin receptors on the caveolae. The piconewton (pN) forces in response to the EGFR-integrin coactivation can be sensed upon the unfolding of the DNA hairpin structure on the side arm of the device via changes of the fluorescence and plasmonic signals. We find that simultaneous activation of EGFR-integrin receptors causes enhanced signal transduction, contractions of the cells, and initiation of the biochemical pathways, thus resulting in a change of the cell division and endocytosis/exocytosis processes that affect the cell proliferation/apoptosis. The DNA-ND further enables us to visualize the cointernalization and degradation of the receptors by lysosomes, providing a novel approach toward bioimaging and mechano-pharmacology. | - |
dc.language | eng | - |
dc.relation.ispartof | Nano Letters | - |
dc.subject | pN forces | - |
dc.subject | DNA nanodevice (DNA-ND) | - |
dc.subject | caveolae | - |
dc.subject | Cell surface receptors | - |
dc.subject | EGFR and integrin | - |
dc.subject | cytoskeleton | - |
dc.title | A DNA Nanodevice Simultaneously Activating the EGFR and Integrin for Enhancing Cytoskeletal Activity and Cancer Cell Treatment | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1021/acs.nanolett.9b03325 | - |
dc.identifier.pmid | 31515999 | - |
dc.identifier.scopus | eid_2-s2.0-85073073099 | - |
dc.identifier.volume | 19 | - |
dc.identifier.issue | 10 | - |
dc.identifier.spage | 7503 | - |
dc.identifier.epage | 7513 | - |
dc.identifier.eissn | 1530-6992 | - |
dc.identifier.isi | WOS:000490353500101 | - |
dc.identifier.issnl | 1530-6984 | - |