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Article: Pri-miR-34b/c rs4938723 Polymorphism is Associated with Decreased Risk and Better Prognosis for Colorectal Cancer Patients

TitlePri-miR-34b/c rs4938723 Polymorphism is Associated with Decreased Risk and Better Prognosis for Colorectal Cancer Patients
Authors
KeywordsPrognosis
Colorectal cancer
Polymorphism
Risk
miR-34b/c rs4938723
China
Issue Date2019
Citation
Archives of Medical Research, 2019, v. 50, n. 2, p. 55-62 How to Cite?
Abstract© 2019 IMSS Background: Colorectal cancer (CRC) is a major cause of cancer-related deaths worldwide. miR-34 induces changes of its downstream genes and plays a key role in altering the apoptotic cycle and pathways of downstream cells and therefore influences carcinogenesis. Objective: The present study investigated whether the single nucleotide polymorphism rs4938723T > C in the promoter of region of miR-34b/c may increase the risk of CRC and influence outcome in patients with CRC. Methods: We enrolled 1078 CRC patients and 1175 cancer-free controls subjects from the Chinese population. miR-34b/c rs4938723T > C polymorphisms were genotyped using a TaqMan PCR method. Results: We found that subjects carrying rs4938723CT/CC genotypes have significantly decreased risk of CRC (adjusted odds ratios (AOR) = 0.75, 95% CI (0.63–0.90) for CT vs.TT; AOR = 0.61, 95% CI (0.46–0.83) for CC vs. TT and AOR = 0.73,95% CI (0.61-0.86) for CT/CC vs. TT) and a significant increased median survival time (MST) compared with those with TT genotypes (MST = 96.500; 75.883 and 71.370 months for CT, CC and CT/CC respectively vs. MST = 54.300 months for TT, p <0.0001). Stratified analysis by both life style and clinicopathological risks revealed that subjects carrying rs4938723CT/CC genotypes were remained significantly associated with increased survival and low risk of CRC compared with those with TT genotypes in all subgroup (all p <0.05). Similar observation was also reported for the prognostic value of rs4938723TC/CC genotypes across all subgroups. Conclusion: These findings indicate that the miR-34b/c rs4938723T > C polymorphism is an independent variable and associated with a decreased risk of CRC in Chinese population. This study provides evidence of the protective effects of rs4938723CT/CC genotypes in the development of CRC.
Persistent Identifierhttp://hdl.handle.net/10722/293118
ISSN
2023 Impact Factor: 4.7
2023 SCImago Journal Rankings: 1.076
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorKassim, Said Abasse-
dc.contributor.authorYang, Xi-
dc.contributor.authorAbbas, Muhammad-
dc.contributor.authorWu, Shenshen-
dc.contributor.authorBaig, Mirza Muhammad Faran Ashraf-
dc.contributor.authorMeng, Qing Tao-
dc.contributor.authorZhang, Chengcheng-
dc.contributor.authorLi, Xiaobo-
dc.contributor.authorChen, Rui-
dc.date.accessioned2020-11-19T09:02:01Z-
dc.date.available2020-11-19T09:02:01Z-
dc.date.issued2019-
dc.identifier.citationArchives of Medical Research, 2019, v. 50, n. 2, p. 55-62-
dc.identifier.issn0188-4409-
dc.identifier.urihttp://hdl.handle.net/10722/293118-
dc.description.abstract© 2019 IMSS Background: Colorectal cancer (CRC) is a major cause of cancer-related deaths worldwide. miR-34 induces changes of its downstream genes and plays a key role in altering the apoptotic cycle and pathways of downstream cells and therefore influences carcinogenesis. Objective: The present study investigated whether the single nucleotide polymorphism rs4938723T > C in the promoter of region of miR-34b/c may increase the risk of CRC and influence outcome in patients with CRC. Methods: We enrolled 1078 CRC patients and 1175 cancer-free controls subjects from the Chinese population. miR-34b/c rs4938723T > C polymorphisms were genotyped using a TaqMan PCR method. Results: We found that subjects carrying rs4938723CT/CC genotypes have significantly decreased risk of CRC (adjusted odds ratios (AOR) = 0.75, 95% CI (0.63–0.90) for CT vs.TT; AOR = 0.61, 95% CI (0.46–0.83) for CC vs. TT and AOR = 0.73,95% CI (0.61-0.86) for CT/CC vs. TT) and a significant increased median survival time (MST) compared with those with TT genotypes (MST = 96.500; 75.883 and 71.370 months for CT, CC and CT/CC respectively vs. MST = 54.300 months for TT, p <0.0001). Stratified analysis by both life style and clinicopathological risks revealed that subjects carrying rs4938723CT/CC genotypes were remained significantly associated with increased survival and low risk of CRC compared with those with TT genotypes in all subgroup (all p <0.05). Similar observation was also reported for the prognostic value of rs4938723TC/CC genotypes across all subgroups. Conclusion: These findings indicate that the miR-34b/c rs4938723T > C polymorphism is an independent variable and associated with a decreased risk of CRC in Chinese population. This study provides evidence of the protective effects of rs4938723CT/CC genotypes in the development of CRC.-
dc.languageeng-
dc.relation.ispartofArchives of Medical Research-
dc.subjectPrognosis-
dc.subjectColorectal cancer-
dc.subjectPolymorphism-
dc.subjectRisk-
dc.subjectmiR-34b/c rs4938723-
dc.subjectChina-
dc.titlePri-miR-34b/c rs4938723 Polymorphism is Associated with Decreased Risk and Better Prognosis for Colorectal Cancer Patients-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.arcmed.2019.05.008-
dc.identifier.pmid31349954-
dc.identifier.scopuseid_2-s2.0-85066987693-
dc.identifier.volume50-
dc.identifier.issue2-
dc.identifier.spage55-
dc.identifier.epage62-
dc.identifier.eissn1873-5487-
dc.identifier.isiWOS:000478708600010-
dc.identifier.issnl0188-4409-

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